A5079998607- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Central Venous Catheters and Hemodialysis
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Sperm and Testicular Function
- COVID-19 Clinical Research Studies
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Lung Cancer Research Studies
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Vascular Malformations and Hemangiomas
- Birth, Development, and Health
- Lipid metabolism and biosynthesis
- Cancer-related gene regulation
- Carcinogens and Genotoxicity Assessment
- Photosynthetic Processes and Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Fungal and yeast genetics research
- Fatty Acid Research and Health
- Cancer-related Molecular Pathways
- Gallbladder and Bile Duct Disorders
- Click Chemistry and Applications
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Cancer Institute
2024
Southwest Hospital
2024
Army Medical University
2024
Capital Medical University
2024
Beijing Chest Hospital
2024
Albany Medical Center Hospital
2018-2023
Sichuan University
2020-2021
Stomatology Hospital
2021
Fanconi anemia is a cancer-prone inherited bone marrow failure and cancer susceptibility syndrome with at least 13 complementation groups (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN). Our laboratory has previously described several regulatory phosphorylation events for core complex member proteins FANCG FANCA by phosphorylation. In this study, we report novel site serine 331 (S331) of the pivotal downstream player pathway. Phosphorylation S331...
Recent findings suggest diverse and potentially multiple roles of small ubiquitin-like modifier (SUMO) in testicular function spermatogenesis. However, SUMO targets remain uncharacterized the testis due to complex multicellular nature tissue, inability maintain manipulate spermatogenesis vitro, technical challenges involved identifying low-abundance endogenous targets. In this study, we performed cell-specific identification sumoylated proteins using concentrated cell lysates prepared with...
This study investigated the impact of maternal high-fat diet on vascular function and endothelial homeostasis in offspring. We found that offspring exposed to exhibited elevated blood pressure, impaired abdominal aortic function, imbalance. These changes were accompanied by increased levels reactive oxygen species (ROS) upregulation pro-inflammatory cytokines (including IL-1β, TNF-α, IL-6, IL-10). Treatment with NLRP3 or IL-1β inhibitors prevented deterioration reduced NO production,...
The advent of immune checkpoint inhibitors (ICIs) therapy has resulted in significant survival benefits patients with non-small-cell lung cancer (NSCLC) without increasing toxicity. However, the utilisation immunotherapy for small-cell (SCLC) remains unclear, a scarcity systematic comparisons therapeutic effects and safety these two major subtypes. Herein, we aimed to provide comprehensive landscape systematically review its specific efficacy advanced cancer, accounting histological types.We...
Objective: To evaluate differences of EML4-ALK positive rates in tissues samples between immunohistochemistry, reverse transcriptase polymerase chain reaction and the next-generation sequencing method. Besides, to compare blood tissue by sequencing. The results provide a basis for selection suitable fusion gene detection Methods: Immunohistochemistry analysis tumors was performed on from 2631 patients with non-small cell lung cancer. mutation 399 cancer detected transcription reaction....
Background: Over 60% of End Stage Renal Disease (ESRD) patients are relying on hemodialysis (HD) to survive, and the arteriovenous fistula (AVF) is preferred vascular access method for HD. However approximately half all newly created AVF fail mature cannot be used without a salvage procedure. We have recently demonstrated an association between maturation failure post-operative fibrosis, while our RNA-seq study also revealed that veins ultimately failed during had elevated levels platelet...
The role of hyaluronan (HA) in the development and progression diabetic kidney disease (DKD), as well precise mechanisms consequences HA involvement this pathology are still to be clarified.In study, we assayed effects synthesis inhibitor 4-methylumbelliferone (4-MU) on DKD. Diabetic type 2 model mice (eNOS-/- C57BLKS/Jdb) were fed artificial diets containing 5% 4-MU or not for 9 weeks. Plasma glucose, glomerular filtration rate (GFR), albumin creatinine ratio (ACR), biomarkers function...
Abstract Celecoxib, a cyclooxygenase-2 inhibitor, can enhance the efficacy of chemotherapy; however, its effect seems inconsistent. In this study, we investigated whether celecoxib would increase antiproliferative effects cisplatin in human lung cancer cells. Our data demonstrated synergistic with wild-type p53 cells and their antagonistic mutated or deleted Combination indices 0.82 to 0.93 reflected between p53. 1.63 3.00 antagonism Compared that p53, apoptosis significantly increased...
Abstract Background: Biliary tract carcinomas (BTCs) are relatively rare but lethal primary malignant tumors derived from the biliary system. The burden of BTCs varies according to sex, age, region, and country, limited attention has been paid BTCs. Methods: We sought explore up-to-date data Global Burden Disease Study expand findings by accessing demographic features BTC disease burden. Using latest 2021 (GBD 2021), we evaluated analyzed distributions patterns in various age groups, sexes,...
Transcription factors can alter the expression of numerous target genes that influence a variety downstream processes making them good targets for anti-cancer therapies. However, directly targeting transcription is often difficult and cause adverse side effects if factor necessary in one or more adult tissues. Identifying upstream regulators aberrantly activate cancer cells offers feasible alternative, particularly these proteins are easy to drug. Here, we describe protocol be used combine...
Abstract Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the downstream effectors of Hippo tumor inhibition pathway. Studies from us others show that inappropriate activation YAP and/or TAZ promotes growth metastasis. Increased expression nuclear localization is observed in many human cancers often predict poor prognosis. Mutations Hippo-YAP/TAZ pathway exist but not common enough to explain frequently increase YAP/TAZ activity cancer. Therefore,...