A5101786870- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Renin-Angiotensin System Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Healthcare and Venom Research
- Musculoskeletal pain and rehabilitation
- Sexual Differentiation and Disorders
- Ion Transport and Channel Regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Steroid Chemistry and Biochemistry
- Hormonal and reproductive studies
- Spine and Intervertebral Disc Pathology
Nanjing Medical University
2023-2025
Jiangsu Province Hospital
2023
Ludwig-Maximilians-Universität München
2018-2021
LMU Klinikum
2018-2021
Wangjing Hospital of China Academy of Chinese Medical Sciences
2009
Chinese Academy of Medical Sciences & Peking Union Medical College
2009
Aldosterone-producing adenomas with somatic mutations in the KCNJ5 G-protein-coupled inwardly rectifying potassium channel are a cause of primary aldosteronism. These drive aldosterone excess, but their role cell growth is undefined. Our objective was to determine adrenal proliferation and apoptosis. The Ki67 proliferative index positively correlated adenoma diameter aldosterone-producing mutation (r=0.435, P=0.007), negative correlation noted no detected (r=-0.548, P=0.023). Human...
In primary aldosteronism (PA) the differentiation of unilateral aldosterone-producing adenomas (APA) from bilateral adrenal hyperplasia (BAH) is usually performed by venous sampling (AVS) and/or computed tomography (CT). CT alone often lacks sensitivity to identify micro-APAs. Our objectives were establish if steroid profiling could be useful for identification patients with micro-APAs and development an online tool differentiate micro-APAs, macro-APAs BAH. The study included PA (n = 197)...
Primary aldosteronism is a common form of endocrine hypertension mainly caused by unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH). AT1R-Abs (autoantibodies to the angiotensin II type 1 receptor) have been reported in patients with disorders associated hypertension. Our objective was assess AT1R-Ab levels primary (APA, n=40 and BAH, n=40) relative (n=40), preeclampsia (n=23), normotensive individuals (n=25). whole sera were measured using 2 different...
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To observe the therapeutic effects of peridural injection Mailuoning Compound Liquor for prolapse lumbar intervertebral disc (PLID).Peridural (MCL) was given to 100 cases PLID, once a week, 4 sessions constituting course. By adopting scoring method, observations were carried out on total effect and changes in 13 items symptoms signs.After treatment, JOA scores this series patients markedly enhanced as compared with before showing significant differences paired t test (P<0.05). The sum...
<title>Abstract</title> Background Congenital adrenocortical hyperplasia caused by 11β-hydroxylase deficiency (11β-OHD) due to <italic>CYP11B1</italic> mutations in 46,XX patients is typically characterized hyporeninemic hypokalemia hypertension, virilization, precocious pseudopuberty, accelerated skeletal maturation and short stature. Impaired fertility has been reported the virilizing 11β-OHD form unless properly treated. Case presentation: A 35-year-old female patient with nonclassical...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Objective: Aldosterone-producing adenomas (APA) are a major cause of primary aldosteronism. Somatic mutations explain the excess aldosterone production in majority patients with APA KCNJ5 encoding potassium channel most prevalent reported populations. Mechanisms driving cell proliferation largely undefined. Design and method: Quantitative transcriptome analysis using RNA-seq was used to identify differentially expressed genes between macro-APAs (n = 9, diameter >= 30 mm) micro-APAs 12,...