A5101687093- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Food Allergy and Anaphylaxis Research
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Epilepsy research and treatment
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Pharmacological Effects and Toxicity Studies
- Eosinophilic Esophagitis
- Adrenal Hormones and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Cancer Treatment and Pharmacology
- Bone health and osteoporosis research
- Adipokines, Inflammation, and Metabolic Diseases
- Machine Learning in Healthcare
- Vitamin D Research Studies
- HER2/EGFR in Cancer Research
Regeneron (United States)
2022-2025
Jiangsu Province Hospital
2014-2024
Nanjing Medical University
2014-2024
Xi'an University of Technology
2013-2024
China University of Mining and Technology
2024
Taihe Hospital
2014-2023
Zhejiang University
2020-2023
Hubei University of Medicine
2014-2023
Shanxi Medical University
2020
Expert System (Italy)
2020
Cellular senescence serves as a fundamental and underlying activity that drives the aging process, it is intricately associated with numerous age-related diseases, including Alzheimer's disease (AD), neurodegenerative aging-related disorder characterized by progressive cognitive impairment. Although increasing evidence suggests senescent microglia play role in pathogenesis of AD, their exact remains unclear. In this study, we quantified levels lactic acid microglia, hippocampus tissues...
Background The coronavirus disease (COVID-19) has become an urgent and serious global public health crisis. Community engagement is the first line of defense in fight against infectious diseases, general practitioners (GPs) play important role it. GPs are facing unique challenges from disasters pandemics delivering care. However, there still no suitable mobile management system that can help collect data, dynamically assess risks, effectively triage or follow-up with patients COVID-19....
Cluster of differentiation (CD)4+CD25+ regulatory T cells (Tregs) exert a suppressive activity on atherosclerosis, but the underlying mechanism remains unclear. Here, we investigated whether and how Tregs affect macrophages foam-cell formation. were isolated by magnetic cell sorting-column analyzed flow cytometry. Macrophages cultured with or without in presence oxidized LDL (oxLDL) for 48 h to transform foam cells. After co-culture Tregs, showed decrease lipid accumulation, which was...
Abstract BACKGROUND: Sunitinib at 50 mg/day on the 4‐weeks‐on‐2‐weeks‐off schedule is current approved regimen for advanced/metastatic renal cell carcinoma (mRCC). Escudier et al reported that continuous, once‐daily dosing with sunitinib 37.5 mg had a manageable safety profile and significant antitumor activity as second‐line mRCC therapy. In this prospective, multicenter, phase II study, we evaluated of continuous first‐line treatment. METHODS: One hundred nineteen treatment‐naive patients...
Objective The relationship between obesity and cardiovascular disease (CVD) remains unclear. This study aims to describe the arterial stiffness in order investigate effects of on CVD. Methods We collected data from 5,158 individuals over 40 years age a cross-sectional Nanjing, China. Anthropometric, demographic, hemodynamic measurements measured through brachial-ankle pulse wave velocity (baPWV) were obtained. Subjects grouped by body mass index (BMI), waist circumference (WC) visceral...
Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present was to explore relationship between vitamin status and TSH levels thyroid autoimmunity taken into consideration a population-based health survey middle-aged elderly Methods. total 1,424 Chinese adults, aged 41-78 years, were enrolled this cross-sectional study. Serum 25(OH)D, TSH,...
In the United States, this real-world study compared effectiveness of dupilumab, benralizumab, and mepolizumab in reducing exacerbations systemic corticosteroid (SCS) prescriptions among patients with asthma.
Objective: Quantify the impact of employee overweight and obesity on costs, absence days, self-reported productivity. Methods: Employees' retrospective body mass index (BMI) values (kg/m2) from 2003 to 2011 health appraisal data defined three cohorts: BMI < 27, 27 ≤ 30, ≥ 30. Medical, pharmacy, sick leave, short-term disability, long-term workers' compensation costs Health Productivity Questionnaire responses were compared using regression modeling, controlling for demographics, salary,...
Non-used clinical information has negative implications on healthcare quality. Clinicians pay priority attention to relevant their specialties during routine practices but may be insensitive or less concerned about showing disease risks beyond specialties, resulting in delayed and missed diagnoses improper management. In this study, we introduced an electronic health record (EHR)-oriented knowledge graph system efficiently utilize non-used buried EHRs. EHR data were transformed into a...
Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of strong cardiac damage. This study aims to explore the role NSUN2 in DOX-induced heart injury. C57BL/6J mice were intraperitoneally injected with 20 mg/Kg DOX induce After 3 days, function, histopathology, myocardial apoptosis, and expression level detected. In vitro, H9C2 cells transfected siRNA or overexpressed lentivirus then treated 500 ng/ml DOX. 24 h, changes reactive oxygen species...
In the United States, dupilumab is approved for moderate-to-severe eosinophilic or oral corticosteroid-dependent asthma, and omalizumab managing allergic asthma uncontrolled by inhaled corticosteroids. However, limited comparative effectiveness data exist these biologics due to differing patient characteristics treatment histories.
The prevalence and burden of atopic dermatitis (AD) are disproportionately high in individuals with skin colour (SOC). Previous research shows that risk for xerosis and/or dyspigmentation is heightened this population may be more bothersome. However, there no patient-reported instruments developed specifically these disease sequelae patients SOC. To develop perform content validation outcome (PRO) questionnaires to assess AD-related A targeted literature review was conducted understand...
Background In Europe, despite approval of multiple biologics for the treatment severe asthma (SA), comparative data from real-world settings are limited. This study compared effectiveness dupilumab with that omalizumab, benralizumab and mepolizumab in European patients SA. Methods EU-ADVANTAGE, physicians France, Italy, Germany, Spain Netherlands were recruited to retrospectively review medical charts (aged ≥12 years) who had physician-confirmed SA initiated dupilumab, or (index) between May...
Atopic dermatitis (AD) can require long-term therapy. Few real-world studies have evaluated effectiveness from the patients' perspective. The aim of this study was to evaluate patient-reported outcomes (PROs) during dupilumab treatment.Adults with moderate-to-severe AD who initiated through US manufacturer patient support program and participated in RELIEVE-AD (a prospective survey a 12-month follow-up) were recontacted 30-36 months post-initiation regardless current use. online...
OBJECTIVE: A cost-per-responder model was developed to compare the pharmacoeconomic value of dupilumab and tralokinumab, in combination with topical corticosteroids (TCS), for treating atopic dermatitis (AD) Italy.METHODS: An indirect treatment comparison (ITC) conducted using placebo arms from LIBERTY AD CAFÈ, CHRONOS, ECZTRA studies as a common comparator assess efficacy versus tralokinumab adult severe patients inadequate responses cyclosporine. Response evaluated at 16 weeks different...
FTO (Fat mass and obesity-associated) is associated with increased risk of obesity type 2 diabetes incurrence. Pancreas islet β cells dysfunction insulin resistance are major causes diabetes. However, whether plays an important functional role in pancreatic as well the related molecular mechanism still unclear. In present study, tissue expression profile was firstly determined using quantitative PCR western blot. widely expressed various tissues presented relative high pancreas tissue,...