A5086565119- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Estrogen and related hormone effects
- Ear Surgery and Otitis Media
- Dental materials and restorations
- Complement system in diseases
- Osteoarthritis Treatment and Mechanisms
- Ear and Head Tumors
- HER2/EGFR in Cancer Research
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Immune Cell Function and Interaction
- Bone health and osteoporosis research
- Tracheal and airway disorders
- T-cell and B-cell Immunology
- Silk-based biomaterials and applications
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Psoriasis: Treatment and Pathogenesis
- Titanium Alloys Microstructure and Properties
- Bone health and treatments
- Electrospun Nanofibers in Biomedical Applications
Virginia Commonwealth University
2016-2025
Regeneron (United States)
2022
Pitié-Salpêtrière Hospital
2021
Sorbonne Université
2021
Assistance Publique – Hôpitaux de Paris
2021
Institut Systèmes Intelligents et de Robotique
2021
The Wallace H. Coulter Department of Biomedical Engineering
2013-2017
Georgia Institute of Technology
2013-2017
Dermatology Specialists
2017
Mercer University
2007-2015
Alterations in cell cycle regulators have been implicated human malignancies including breast cancer. PD 0332991 is an orally active, highly selective inhibitor of the cyclin D kinases (CDK)4 and CDK6 with ability to block retinoblastoma (Rb) phosphorylation low nanomolar range. To identify predictors response, we determined vitro sensitivity across a panel molecularly characterized cancer lines.Forty-seven immortalized lines representing known molecular subgroups were treated determine IC50...
Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template design manufacture Ti-6Al-4V with varying porosity via sintering. Characterization of revealed interconnected porosities ranging from 15-70% compressive moduli 2579-3693 MPa. These macro were further surface-treated create desirable multi-scale micro-/nano-roughness, which has been shown enhance the...
Abstract Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium onlay device produced by additive manufacturing (AM) post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth...
The purpose of this study was to compare the biological effects in vivo hierarchical surface roughness on laser sintered titanium-aluminum-vanadium (Ti-6Al-4V) implants those conventionally machined osteoblast response vitro and osseointegration. Laser disks were fabricated have micro-/nano-roughness wettability. Control computer numerical control (CNC) milled then polished be smooth (CNC-M). (LST-M), grit blasted (LST-B), or acid etched (LST-BE). LST-BE manufactured by CNC milling (CNC-B)...
The human EGF (HER) family of receptors has been pursued as therapeutic targets in breast cancer and other malignancies. Trastuzumab lapatinib are standard treatments for HER2-amplified cancer, but a significant number patients do not respond or develop resistance to these drugs. Here we evaluate the vitro activity dacomitinib (PF-00299804), an irreversible small molecule pan-HER inhibitor, large panel cell lines with variable expression HER ligands, sensitivity trastuzumab lapatinib....
Long term success of bone-interfacing implants remains a challenge in compromised patients and areas low bone quality. While surface roughness at the micro/nanoscale can promote osteogenesis, macro-scale porosity is important for promoting mechanical stability implant over time. Currently, machining techniques permit pores to be placed throughout implant, but are generally uniform dimension. The advent laser sintering provides way design manufacture with specific variable dimensions high...
The osteoblastic differentiation of bone marrow stromal cells (bMSCs), critical to the osseointegration titanium implants, is enhanced on surfaces with biomimetic topography, and this further when are hydrophilic. This a result changing surface free energy change protein adsorption, improving cell attachment differentiation, bone-to-implant contact in patients. In study, we examined different methods plasma treatment, well-accepted method increasing hydrophilicity, evaluated changes...
Height is the result of many growth and development processes. Most genes associated with height are known to play a role in skeletal development. Single-nucleotide polymorphisms SPAG17 gene have been human height. However, it not clear how this influences linear growth. Here we show that targeted mutation Spag17 leads malformations. Hind limb length mutants was significantly shorter than wild-type mice. Studies revealed differences maturation femur tibia suggesting alterations patterning....
Abstract Objectives This study determined whether implant surfaces that promote osseointegration in normal rats can osteoporotic without pharmacologic intervention. Materials and Methods Virgin female 8‐month‐old CD Sprague Dawley ( N = 25) were ovariectomized. At 6 weeks, microstructured/non‐nanostructured/hydrophobic, microstructured/nanostructured/hydrophobic, or microstructured/nanostructured/hydrophilic Ti implants (Ø2.5 × 3.5 mm; Institut Straumann AG, Basel, Switzerland) placed the...
The surface topography and chemistry of titanium–aluminum–vanadium (Ti6Al4V) implants play critical roles in the osteoblast differentiation human bone marrow stromal cells (MSCs) creation an osteogenic microenvironment. To assess effects a microscale/nanoscale (MN) topography, this study compared MN-modified, anodized, smooth Ti6Al4V surfaces on MSC response, for first time, directly contrasted MN-induced with culture tissue polystyrene (TCPS) medium (OM). Surface characterization revealed...
Metal 3D printing is increasingly being used to manufacture titanium–aluminum–vanadium (Ti6Al4V) implants. In vitro studies using 2D substrates demonstrate that the osteoblastic differentiation of bone marrow stromal cells (MSCs) on Ti6Al4V surfaces, with a microscale/nanoscale surface topography mimics an osteoclast resorption pit, involves non-canonical Wnt signaling; Wnt3a downregulated and Wnt5a upregulated, leading local production BMP2 semaphorin 3A (sema3A). this study, it was...
OBJECTIVE To propose a CT‐based method for early identification of severe cases malignant external otitis (MEO) by correlating between initial CT findings and clinical course. STUDY DESIGN AND SETTING Eighteen MEO patients who underwent on admission were included in this retrospective study conducted at tertiary center. The number extent anatomical areas involved according to compared course severity. RESULTS categorized into two groups There 13 the “nonsevere” group 5 “severe.” In six out...
Pityriasis rubra pilaris (PRP) is an exceptionally rare, chronic inflammatory dermatosis of unknown etiology. Patients classically present with small, follicular keratosis and salmon-colored plaques that begin at the head neck slowly progress to widespread erythroderma including palms soles. It difficult distinguish PRP from other dermatoses; however, features help aid in diagnosis include 'islands' spared skin, orangish hue typical findings on biopsy. There are no specific guidelines...
An aging population, decreased activity levels and increased combat injuries, have led to an increase in critical sized bone defects. As more defects are treated using allografts, which is the current standard of care, deficiencies allografts becoming evident. Allografts lack angiogenic potential induce sufficient vasculogenesis counteract hypoxic environment associated with In this study, aptamer-functionalized fibrin hydrogels (AFH), engineered release vascular endothelial growth factor...