A5100414432- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Cytomegalovirus and herpesvirus research
- Cervical Cancer and HPV Research
- Machine Learning in Healthcare
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- COVID-19 diagnosis using AI
- Virology and Viral Diseases
- Mobile Health and mHealth Applications
- Blood groups and transfusion
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- AI in cancer detection
- Energy, Environment, Economic Growth
- Health Literacy and Information Accessibility
- Inflammasome and immune disorders
- Genital Health and Disease
- Malaria Research and Control
- Statistical Methods and Inference
First Affiliated Hospital Zhejiang University
2014-2025
Sun Yat-sen University
2016-2025
Zhejiang University
2014-2025
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Tangshan Gongren Hospital
2025
Tumor Hospital of Xinjiang Medical University
2024
Second Hospital of Anhui Medical University
2022-2024
Anhui Medical University
2022-2024
China Railway Economic and Planning Research Institute
2024
Nanjing Xiaozhuang University
2021-2024
Multi-drug resistant hepatitis B virus (HBV) has been reported in patients who received sequential antiviral therapy. In vitro studies showed that HBV constructs with mutations to lamivudine and adefovir have marked reduction sensitivity combination of adefovir, whereas either drug remain sensitive the other drug. We conducted this study determine whether conferring resistance multiple agents co-locate on same genome vivo describe evolution these mutations. Sera from six had found multi-drug...
Background The coronavirus disease (COVID-19) has become an urgent and serious global public health crisis. Community engagement is the first line of defense in fight against infectious diseases, general practitioners (GPs) play important role it. GPs are facing unique challenges from disasters pandemics delivering care. However, there still no suitable mobile management system that can help collect data, dynamically assess risks, effectively triage or follow-up with patients COVID-19....
Abstract Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal preventing infection. Next-generation which able to induce mucosal immunity the upper respiratory prevent or reduce infections highly transmissible variants of urgently needed. We have developed an intranasal vaccine candidate based on a live attenuated influenza virus (LAIV) with deleted NS1 gene that encodes cell surface expression...
Hepatitis B virus affects more than 2 billion people worldwide, 350 million of which have developed chronic hepatitis (CHB). The genetic factors that confer CHB risk are still largely unknown. We sought to identify variants for susceptibility in the Chinese population. undertook a genome‐wide association study (GWAS) 2,514 cases and 1,130 normal controls from eastern China. replicated 33 most promising signals eight previously reported loci through two‐stage validation totaling 6,600 8,127...
Objective The purpose of this study was to evaluate the clinical diagnostic value metagenomic next-generation sequencing (mNGS) for tuberculosis (TB). Methods This retrospective included 52 patients with suspected TB infection. mNGS, targeted PCR, acid-fast staining and, T-SPOT.TB assay were performed on specimen. positive rate mNGS and traditional detection methods statistically analyzed. Pathological tests when necessary. Results In total, in analysis, 31 finally diagnosed TB. Among...
Background A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection Japanese. This study evaluates effects of these risk Chinese, where HBV is most popular world. Methods and Findings We have assessed relationship between single nucleotide polymorphisms (rs3077 rs9277535) chronic independent case-control studies. The first population Chinese Han included 736 patients 782 spontaneously recovered controls. second set was...
Neonicotinoid insecticides are commonly used for pest control on tea plantations as a result of their broad-spectrum activity. However, neonicotinoid residues released from leaves into infusions pose dietary risk to consumers. Therefore, rapid, sensitive, and reliable on-site detection method neonicotinoids is needed. We developed quantum-dot-based fluorescent lateral flow immunochromatographic strip (LFICS) combined with broad-specific antibody typical (imidacloprid, imidaclothiz,...
A comprehensive evaluation of the burden inflammation bowel disease (IBD) is important for identifying potential strategies to control disease. We present results from Global Burden Diseases (GBD) 2017 IBD at national level, trends in and its epidemiological features China.Using methods GBD 2017, we describe based on prevalence, incidence, mortality, years lost (YLLs), life lived with disability (YLDs) disability-adjusted (DALYs) China estimated using DisMod-MR 2·1. additionally evaluated...
Recurrence remains the primary cause of death in patients with breast cancer. Although machine learning can efficiently predict prognosis cancer patients, black-box nature model may result a lack evidence for clinicians when making critical decisions.
Human herpesvirus 7 (HHV-7) was isolated frequently from saliva specimens. The isolation rates were 81% (13/16) in adults, 70% (7/10) children over 1 year old, and none (0/7) less than respectively, indicating that infection of HHV-7 occurs during early infancy the virus shedding rate after is very high. 6 (HHV-6) not specimens although some studies on HHV-6 reported previously.
China's HIV cases are growing by more than 30% annually. Few researchers have been able to reach sex workers and examine their risk behavior patterns. Key informants in illegal prostitution connected with owners of establishments Beijing recruit the involvement workers. A total 69 were surveyed about background behaviors spring, 2000 four venues; hair salons, bathing centers, karaoke bars, street. The women mostly young (in 20s), low socioeconomic status, from small towns villages. They...
In this study, a rapid and sensitive immunochromatographic strip (ICS) assay, based on quantum dots (QDs), was developed for the qualitative quantitative detection of acetamiprid in agricultural samples. Acetamiprid-ovalbumin conjugates (ACE-OVA) goat anti-mouse IgG were sprayed onto nitrocellulose membrane as test control line. Two kinds anti-acetamiprid monoclonal antibodies (mAb) obtained our lab characterized by ELISA surface plasmon resonance assay. The competitive immunoassay...
Objectives: The purpose of this study is to evaluate the clinical application value metagenomic next-generation sequencing (mNGS) in central nervous system (CNS) infections. Methods: Both mNGS and routine examination cerebrospinal fluid (CSF) samples from patients with CNS infections retrospectively analyzed efficacy cohort were ultimately compared a diagnosis. Results: A total 94 cases consistent included analysis. positive rate for 60.6% (57/94), which significantly higher than 20.2%...
Mobile phones and mobile phone apps have expanded new forms of health professionals' work. There are many studies on the use for different specialists. However, there no current among general practitioners (GPs).The objective study was to investigate extent which GPs own smartphones with them aid their clinical activities.A questionnaire survey undertaken in Hangzhou, Eastern China. Data probing GPs' medical activities factors influencing app were collected analyzed125 participated survey....
Abstract HPV integration plays an important role in cervical carcinogenesis. genotypes and the exact sites were investigated using capture technology combined with next generation sequencing 166 women. Three, one six verified 7 HPV-positive ‘normal epithelium’, 6 CIN2 15 CIN 3 samples, respectively. Of 10 integrations, nine involved HPV33 HPV16, Our study accurately evaluated level CINs normal tissues high-throughput viral detection method providing basic evidence for integration-driven
Interferon (IFN)‐α is a first‐line therapy for chronic hepatitis B (CHB) patients but only initiates response in minority of patients. A genetic variant, rs7574865 STAT4 , was recently reported to be associated with risk developing CHB and virus‐related hepatocellular carcinoma. We aimed determine whether this variant the IFNα treatment e antigen (HBeAg)‐positive studied 466 HBeAg‐positive who received either IFNα‐2b (n = 224) or pegylated IFNα‐2a 242) 48 weeks were followed an additional 24...
Urban China provides a unique setting to examine the urban energy transitions. Rizhao, Chinese ‘solar city’ is known for rapid spread and popularization of solar hot water systems since 1990s. In this paper we seek understand how specific conditions in Rizhao have favored adoption extent that can speak an transition towards energy. To do so, introduces novel framework – Dimensions Energy Transitions (DUET) building upon theoretical thinking both transitions studies studies. The case...
Background: Globally, mHealth is increasing as a promising technology for promoting the quality of health care. Thus, growing number internet hospitals have been established in China to avail all its advantages. However, no study has investigated service scope and patient satisfaction hospital date. Objective: The objective our was explore features outpatients general practice, disease information, through an rating site. Methods: We collected data from First Affiliated Hospital, Zhejiang...
Alcoholic liver damage has become a widespread health problem as alcohol consumption increases and is usually identified by elevated transaminase. We conducted this study to investigate the role of gut microbiome in individual susceptibility alcoholic injury. divided participants into four groups based on transaminase elevation, which were drinking case group, control non-drinking group. The group meant who consumers with found that alpha beta diversities differed from other three groups....
Accurate quantification of hepatitis B virus (HBV) DNA levels is important for monitoring patients with chronic HBV infection and assessing their responses to antiviral therapy. This study aimed develop a real-time PCR assay that sensitive can accurately quantify wide range across the known genotypes. An "in-house" using primers TaqMan probe in highly conserved region surface gene was designed. The standardized against WHO standard validated plasmids genotypes A through H. linear...
Abstract Gentrification in China is intertwined with urban redevelopment, which causes the large‐scale displacement of rural–urban migrants from ‘villages city’ (ViCs). Because informality ViCs, migrant renters have very insecure tenancy and during redevelopment they are treated as a negligible (‘invisible’) social group. As difficult to locate after displacement, also literally invisible researchers. To make visible, this study traced sample displaced Huangbeiling village Shenzhen. The...