A5060992863- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Synthesis of Organic Compounds
- Natural Compound Pharmacology Studies
- Phytochemical compounds biological activities
- Biological Stains and Phytochemicals
- Metal-Catalyzed Oxygenation Mechanisms
- Plant-Derived Bioactive Compounds
- Advanced oxidation water treatment
- Oxidative Organic Chemistry Reactions
- Cancer Treatment and Pharmacology
- Biological Activity of Diterpenoids and Biflavonoids
- Plant biochemistry and biosynthesis
- Microbial Metabolism and Applications
- Enzyme Catalysis and Immobilization
- Alzheimer's disease research and treatments
- Phytochemistry and Bioactive Compounds
- Pharmacogenetics and Drug Metabolism
- Genomics and Phylogenetic Studies
- Seaweed-derived Bioactive Compounds
- Natural product bioactivities and synthesis
- Synthetic Organic Chemistry Methods
Hubei University
2023-2025
Huazhong University of Science and Technology
2016-2022
Molina Center for Energy and the Environment
2018
To explore the chemical diversity of metabolites from endophytic fungi, strain Phomopsis sp. TJ507A, isolated medicinal plant Phyllanthus glaucus, was investigated. A 2,3-seco-protoilludane-type sesquiterpenoid (1), eight protoilludane-type sesquiterpenoids (2–9), four illudalane-type (10a/10b, 11, and 12), a botryane-type (13) in addition to seven known (14–20) were identified liquid culture fungus. Structures compounds, including their absolute configurations, elucidated based on extensive...
Abstract Rising drug resistance limits the treatment options infected by methicillin-resistant Staphylococcus aureus (MRSA). A promising solution for overcoming of MRSA is to inhibit penicillin-binding protein 2a (PBP2a). novel terpene-polyketide hybrid meroterpenoid, aspermerodione ( 1 ), characterized an unusual 2,6-dioxabicyclo[2.2.1]heptane core skeleton, and a new heptacyclic analogue, andiconin C 2 were isolated identified from liquid cultures endophytic fungus Aspergillus sp. TJ23....
Chemical investigation of <italic>Aspergillus terreus</italic> resulted in the identification terreusterpenes A–D with potential BACE1 and AchE inhibitory activities.
Eighteen compounds, including eight new cassane-type furanoditerpenoids, 3β-hydroxyphanginin H (1), 3β-acetoxyphanginin (2), 7β-acetoxyphanginin (3), 7β-hydroxyphanginin (4), 4-epi-3β-hydroxycaesalpinilinn (5), 4-epi-3β-acetoxycaesalpinilinn (6), 20-acetoxytaepeenin D (7), and tomocin E (8), along with 10 known compounds (9-18) were isolated from the roots of Caesalpinia decapetala. Compounds 1-13 C. decapetala for first time. The their absolute configurations determined by extensive...
A pyridone alkaloid, asperpyridone (1), which possesses an unusual pyrano[3,2-c]pyridine scaffold, was isolated from solid cultures of the endophytic fungus Aspergillus sp. TJ23. Its structure, including its absolute configuration, determined using a combination nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, quantum chemical calculations (electronic circular dichroism), and X-ray crystallography. In vitro bioassays demonstrated that (1) could function...
Two new polyketide compounds, asperulosins A and B ( 1 – 2 ), one prenylated small molecule, asperulosin C 3 along with nine known compounds 4 12 were isolated identified from a fungus Aspergillus rugulosa . Their structures extensively elucidated via HRESIMS, 1D, 2D NMR analysis. The absolute configurations of the determined by comparison their electronic circular dichroism (ECD), calculated ECD spectra, detailed discussion those in previous reports. Structurally, belonged to family...
Three PPAPs were isolated from <italic>H. longistylum</italic> Oliv.
Nine new sesquiterpene alkaloids, eurochevalierines A
Chemical investigation of <italic>Hypericum przewalskii</italic> Maxim. resulted in the identification six new epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with potential immunosuppressive activity.
Wilsonglucinols A–C (<bold>1–3</bold>), three new polycyclic polyprenylated acylphloroglucinols (PPAPs) possessing novel homoadamantane architectures based on unusual epoxy-ring-fused systems were isolated from <italic>Hypericum wilsonii</italic>.
A novel homologous polyketide dimer, asperosin (1), constructed with a unique hetero-bicycle 6/5 core skeleton featuring four continuous quaternary carbons, was isolated from solid culture of the fungus Aspergillus rugulosa .
Fungal bifunctional terpene synthase PstA catalyzes the formation of 5/15 cis -fused ring system.
Eight secondary metabolites, including a new polyketide, named asperetide (1) and prenylxanthone derivative, called asperanthone (4), six known compounds, (S)-3-butyl-7-methoxyphthalide (2), ruguloxanthone C (3), tajixanthone hydrate (5), methanoate (6), salimyxin B (7), ergosterol (8), were isolated identified from the medicinal plant-derived fungus, Aspergillus sp. TJ23. The structures their absolute configurations elucidated via multiple methods, 1D- 2D-NMR, HR-ESI-MS, UV, IR, electronic...
The flavoprotein monooxygenase (FPMO) TerC is encoded by all known cyclopentene biosynthetic gene clusters. It can catalyze oxidative dearomatization toward a series of 6-HM analogues and further induces different skeletal distortions to form either benzoquinone or pyrone bimodal reaction cascades, which only governed the C7 substitutions. Beyond our study demonstrated cascades advanced knowledge fungal cyclopentenes, this work also sets stage for bioengineering polyketides.
Correction for ‘The absolute configurations of hyperilongenols A–C: rare 12,13-<italic>seco</italic>-spirocyclic polycyclic polyprenylated acylphloroglucinols with enolizable β,β′-tricarbonyl systems from <italic>Hypericum longistylum</italic> Oliv.’ by Na Zhang, <italic>et al.</italic>, <italic>Org. Chem. Front.</italic>, 2019, DOI: 10.1039/c9qo00245f.
Three undescribed 30-norlanostane triterpenoids named aspertrinoids A–C (1–3), along with two oleanane type triterpenoids, D (5) and E (6) three known congeners, were isolated from the fungus Aspergillus sp. TJ507. Their structures determined by NMR, HRESIMS, X-ray diffraction analyses ECD comparison. Structurally, (1–3) a hemiacetal moiety formed between C-3 C-19, which have been reported only members before acted as intermediates lanostanes conventional steroids based on biosynthesis...