A5100431754- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
- Oxidative Organic Chemistry Reactions
- Sulfur-Based Synthesis Techniques
- Cell death mechanisms and regulation
- Metal complexes synthesis and properties
- Chemical Synthesis and Reactions
- Fluorine in Organic Chemistry
- Computational Drug Discovery Methods
- Advanced Photocatalysis Techniques
- Ferrocene Chemistry and Applications
- Biochemical and Molecular Research
- Synthesis and Catalytic Reactions
- Crystal structures of chemical compounds
- Advanced Synthetic Organic Chemistry
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Click Chemistry and Applications
- TiO2 Photocatalysis and Solar Cells
- Chemical synthesis and alkaloids
- Catalytic Cross-Coupling Reactions
- Analytical Chemistry and Chromatography
- Radical Photochemical Reactions
State Key Laboratory of Food Science and Technology
2025
Nanchang University
2025
Tsinghua University
2023-2024
Renmin University of China
2018-2024
Bioscience (China)
2024
Wenzhou University
2018-2024
Tongji Hospital
2024
Jilin Normal University
2016-2024
State Key Laboratory of Chemical Engineering
2023-2024
Huazhong University of Science and Technology
2024
Tumor necrosis factor receptor type 1 (TNF-R1) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear kappa B (NF-κB) activation. Normally, these signals are generated only after TNF-induced aggregation. However, TNF-R1 self-associates independently ligand when overexpressed. This apparent paradox may be explained by silencer domains (SODD), widely expressed ∼60-kilodalton protein was found to associated with TNF-R1. treatment...
Abstract Controlling selectivity is of central importance to radical chemistry. However, the highly reactive and unstable intermediates make this task especially challenging. Herein, a strategy for taming redox reactions has been developed, in which solvent‐bonding can alter reactivity generated thereby drastically reaction at room temperature. Various β‐oxy sulfoxides β‐hydroxy sulfides be facilely obtained, some are difficult synthesize by existing methods. Notably, neither metal catalyst...
Protein lysine succinylation, an emerging protein post-translational modification widespread among eukaryotic and prokaryotic cells, represents important regulator of cellular processes. However, the extent function succinylation in Mycobacterium tuberculosis, especially extensively drug-resistant strain, remain elusive. Combining protein/peptide prefractionation, immunoaffinity enrichment, LC-MS/MS analysis, a total 686 succinylated proteins 1739 sites M. tuberculosis were identified,...
Hair loss is a growing esthetic condition driven by complex mechanisms that has numerous psycho-social implications.Conventional drug applications usually focus on single treatment target, and the penetration depth restricts post-delivery effect.Method: We fabricated curcumin-zinc framework (ZnMOF) encapsulated gamma-polyglutamic acid (γ-PGA) microneedle patch (ZnMOF-MN) as multifunctional biosafe transdermal delivery system.ZnMOF was characterized with field emission scanning electron...
A direct aliphatic C–H <sup>18</sup>F labeling method using [<sup>18</sup>F]fluoride ion at inaccessible and unreactive sites is reported.
The stability of protein drugs remains one the key hurdles to their success in market. aim present study was design a novel nanoemulsion drug-delivery system (NEDDS) that would encapsulate standard-model drug--bovine serum albumin (BSA)--to improve drug stability.The BSA NEDDS prepared using phase-inversion method and pseudoternary phase diagrams. following characteristics were studied: morphology, size, zeta potential, loading, encapsulation efficiency. We also investigated NEDDS,...
Abstract The feasibility of photocatalytic reduction nitrobenzene using titanium dioxide powder as photocatalyst, under the protection nitrogen and presence hole scavenger conditions, was studied. Effects illumination time, amount catalyst sorts solvent on were investigated, respectively. results showed that, for nitrobenzene, aniline main product. When time 6 h, 8.15×10 −4 mol/L could be photocatalytically reduced completely, with yield being 88.5%. optimum TiO 2 used 4.0 g/L, initial pH...
A highly regio- and enantioselective allylic alkylation of sodium thiophenoxide has been realized by [Ir(COD)Cl](2)/phosphoramidite along with CsF as an additive, producing enantioenriched allyl phenyl sulfide compounds up to 99% ee.
Abstract Intrinsic solubility is a critical property in pharmaceutical industry that impacts in-vivo bioavailability of small molecule drugs. However, prediction with Artificial Intelligence(AI) are facing insufficient data, poor data quality, and no unified measurements for AI physics-based approaches. We collect 7 aqueous datasets, present dataset curation workflow. Evaluating the curated two expanded deep learning methods, improved RMSE scores on all thermodynamic datasets observed. also...
An efficient method of α-keto amides to α-hydroxy has been developed for the regioselective hydrogenation reduction. Under assistance electricity and methanol as both hydrogen source solvent,...
A radical cascade cyclization strategy has been developed to provide a direct route access 3-acylbenzothiophenes from simple chemical feedstocks.
The main proteases (Mpro ) are highly conserved cysteine-rich proteins that can be covalently modified by numerous natural and synthetic compounds. Herein, we constructed an integrative approach to efficiently discover covalent inhibitors of Mpro from complex herbal matrices. This work begins with biological screening 60 clinically used antiviral medicines, among which Lonicera japonica Flos (LJF) demonstrated the strongest anti-Mpro effect (IC50 = 37.82 μg/mL). Mass spectrometry (MS)-based...