A5101492121- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Synthesis and biological activity
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Bioactive Natural Diterpenoids Research
- Chemical Synthesis and Analysis
- Plant Stress Responses and Tolerance
- Polysaccharides and Plant Cell Walls
- Fungal Biology and Applications
- Plant-Microbe Interactions and Immunity
- Time Series Analysis and Forecasting
- Sesquiterpenes and Asteraceae Studies
- Ferrocene Chemistry and Applications
- Ferroptosis and cancer prognosis
- Phytochemical compounds biological activities
- Geological Modeling and Analysis
- Machine Fault Diagnosis Techniques
- Inflammatory Bowel Disease
- Phenothiazines and Benzothiazines Synthesis and Activities
- Data Mining Algorithms and Applications
- Traditional and Medicinal Uses of Annonaceae
- Escherichia coli research studies
- Synthesis and Catalytic Reactions
- Synthesis of β-Lactam Compounds
Nankai University
2013-2025
Tianjin International Joint Academy of Biomedicine
2012-2023
State Key Laboratory of Medicinal Chemical Biology
2021-2023
Xinjiang Institute of Engineering
2023
North China University of Technology
2023
Shenyang Pharmaceutical University
2020
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2016
Abstract In this study, we investigated the therapeutic potential of lentinan in mouse models inflammatory bowel disease ( IBD ) and colitis‐associated cancer CAC ). Lentinan decreased activity index macroscopic microscopic colon tissue damage dextran sulphate sodium DSS )‐induced or TNBS ‐induced colitis. High‐dose was more effective than salicylazosulfapyridine number tumours, cell infiltration, atypical hyperplasia nuclear atypia azoxymethane/ model. It also expression pro‐inflammatory...
In the field of class-agnostic counting (CAC), only objects interest that are similar to exemplars in multi-class scenarios has been a challenging task. To address this challenge, recent research proposed extract-and-match paradigm based on vision transformer (ViT) architecture. However, although can improve accuracy exemplar-similar object identification, it overly emphasizes role ViT structure. shortcoming, work introduces more generalized prompt-before-extract top and designs pure...
ABSTRACT Shiga-like toxins (Stxs), produced by pathogenic Escherichia coli , are a major virulence factor involved in severe diseases human and animals. These ribosome-inactivating proteins, treatment for caused them is not available. Therefore, there an urgent need agents capable of effectively targeting this lethal toxin. In study, we identified baicalin, flavonoid compound used Chinese traditional medicine, as against toxin 2 (Stx2). We found that baicalin significantly improves renal...
One new dimeric cyclohexylethanoid derivative (1) and one rearranged abietane diterpenoid (2) were isolated from Clerodendrum bungei C. inerme, respectively, together with 11 known compounds. The structures of the compounds elucidated by detailed spectroscopic ECD analyses. absolute configuration 2 was unequivocally determined using single-crystal X-ray diffraction analysis. Compound 1 showed greatest inhibitory effect on NO production in RAW 264.7 murine macrophages induced...
ABSTRACT Fourteen new ferrocene derivatives containing urea linker were synthesized from the reaction of ferrocenecarbonyl azide with aromatic amines. The structures synthetic compounds confirmed by 1 H NMR, 13 C IR, mass spectrometry and elemental analysis. These organometallic evaluated in vitro protease assay using fluorogenic substrate peptide, several showed potent inhibition against HIV‐1 protease. Copyright © 2012 John Wiley & Sons, Ltd.
5-Hydroxyindole derivatives have various demonstrated biological activities. Herein, we used 5-hydroxyindole as a synthetic starting point for structural alterations in combinatorial process to synthesize 22 different compounds with EZH2 inhibitor pharmacophores. A series of 5-hydroxyindole-derived were screened inhibitory activities against K562 cells. According molecular modeling and vitro activity assays, the preliminary structure-activity relationship was summarized. Compound L–04...
Nearly all antibiotics are ineffective to the antibiotic-resistant bacteria New Delhi metallo-beta -lactamase-1(NDM-1), one of most important reasons is that can be hydrolyzed by NDM-1 in these bacteria. Up date, Many compounds, including captopril, found possess inhibition activity. Herein we report some cysteine derivatives or homocysteine inhibit protein, and lead compound 9 has protein with IC50 1 µM, which about 8 times potency captopril. Keywords: IC50, NDM-1, cysteine, derivatives, inhibition.
Abstract Drive circuit is a critical part of instrumentation and control systems in nuclear reactors, its performance directly influences the operation reactors. However, comparing with open IGBT faults, soft faults caused by degradation electronic components present much slighter fluctuations to drive circuits. If two fault modes co‐exist, traditional diagnosis models are prone misclassify as normal condition. To improve accuracy circuits, it necessitates accurately locate while effectively...
The history of artificial intelligence (AI) has witnessed the significant impact high-quality data on various deep learning models, such as ImageNet for AlexNet and ResNet. Recently, instead designing more complex neural architectures model-centric approaches, attention AI community shifted to data-centric ones, which focuses better processing strengthen ability models. Graph learning, operates ubiquitous topological data, also plays an important role in era learning. In this survey, we...
<title>Abstract</title> Remdesivir, a broad-spectrum antiviral prodrug, has been investigated for its potential effects on inflammatory bowel disease (IBD). Using mouse model with acute colitis induced by 3% dextran sulfate sodium (DSS), we administered remdesivir at doses of 12.5 and 25 mg/kg from day 1 to 7. Our research demonstrated that treatment notably decreased activity scores improved colon tissue damage under the microscope. It also boosted levels tight junction proteins such as...
Ethnopharmacological relevance: The flowers of I. japonica (Inulae Flos) can be used to treat cough, asthma and remove phlegm in traditional Chinese medicine (TCM).Aim the study: purpose our research was obtain active components with inhibition inflammation MUC5AC production alleviate symptoms from japonica.Materials methods: compounds were separated a methanol extract by column chromatography over silica gel, AB-8 macroporous resin column, MPLC semipreparative HPLC. After separation...
Chinese spelling correction (CSC) is a traditional Natural Language Processing task that aims to detect and correct errors in text. Many advanced studies have adopted BERT non-autoregressive language models, masking method performs well on the CSC task. However, model still has certain limitations. Firstly, predicts tokens based assumption of independence, meaning it does not learn relationships between masked tokens. As result, fails character-level dependencies effectively. Additionally,...