A5019335212- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Nuclear Receptors and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic Associations and Epidemiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Alcohol Consumption and Health Effects
- Bone Metabolism and Diseases
- Biomarkers in Disease Mechanisms
- Nutrition and Health in Aging
- Dental Health and Care Utilization
- Pregnancy and preeclampsia studies
- Blood Coagulation and Thrombosis Mechanisms
- Frailty in Older Adults
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Protease and Inhibitor Mechanisms
- Intracranial Aneurysms: Treatment and Complications
Wannan Medical College
2018-2025
First Affiliated Hospital of Wannan Medical College
2018-2025
Nanjing Medical University
2018-2020
Nanjing General Hospital of Nanjing Military Command
2020
This study aimed to construct a nomogram predicting oral frailty risk in Older adults patients with stroke. A cross-sectional study. We selected 664 hospitalised older stroke tertiary hospital from January 2023 March 2024. Among them, 451 cases December formed the modelling group, and 213 2024 served as validation group. Univariate multivariate logistic regression analyses identified independent factors for frailty. was developed visualised using columnar charts. The model's predictive...
Background and purpose The aim of the study was to evaluate whether leukoaraiosis severity is associated with outcome in acute stroke patients undergoing mechanical thrombectomy stent-retriever devices. Methods In this retrospective multicenter study, we evaluated 251 (pretreatment National Institutes Health Stroke Scale score ≥8) treated Leukoaraiosis graded as 0–2 (absent-to-moderate) versus 3–4 (severe) according van Swieten scale. main clinical proportion good functional outcome, defined...
Ischemic stroke is one of the major causes death and long‑term disability worldwide. C‑reactive protein (CRP) as a potential biomarker for functional outcome after acute ischemic remains controversial. The aim present study was to examine association between level CRP stroke. A total 218 consecutive patients with within 24 h onset were recruited study. Poor defined modified Rankin scale score >2 at 3 months retrospective analysis performed investigate whether associated poor months....
Background: Blood pressure (BP), recanalization status, and collateral circulation are important factors for cerebral autoregulation after stroke. We aimed to investigate the association of various BP variability (BPV) parameters with clinical outcomes mechanical thrombectomy (MT) according status. Methods: included 502 consecutive patients who underwent MT due anterior large vessel occlusion stroke at three comprehensive centers. BPV were standard deviation (SD), maximum/minimum BP,...
The inflammatory response plays a vital role in the development of in-stent restenosis (ISR) after carotid angioplasty and stenting (CAS). neutrophil to lymphocyte ratio (NLR) has been suggested as sensitive marker. We explored association between NLR ISR CAS patients. A total 427 patients who underwent were enrolled. Neutrophil was measured before procedure. Clinical examination radiographic evaluation performed at 6 months annually In-stent defined ≥50% stenosis treated lesion. Cox...
To develop and validate a novel tool for predicting the development of malignant brain edema (MBE) in large vessel occlusion stroke patients after endovascular thrombectomy (EVT).We used prospectively registered population EVT from three comprehensive centers. The was randomly divided into two subsets (7:3): training cohort an internal validation cohort. External performed using Endovascular Treatment Acute Anterior Circulation Ischemic Stroke Registry China (ACTUAL) database. MBE defined as...
Neurological deterioration (ND) is a devastating complication for patients with ischemic stroke after endovascular recanalization therapy (EVT). We aimed to investigate the time course and clinical relevance of ND EVT. Consecutive acute who underwent EVT large arterial occlusions anterior cerebral circulation were enrolled. The National Institutes Health Stroke Scale (NIHSS) scores assessed before EVT, at end 24 h (d1), on day 3 (d3), 15 (d15), discharge anytime when was indicated. defined...
Background: A recent genome-wide association study has identified that rs4376531 variant conferred risk of atherothrombotic stroke (AS) in a Japanese population. This was to explore the Han Chinese population.Methods: total 1036 cases and 643 healthy controls were enrolled. We genotyped with SNPscan. Multivariate logistic regression analysis used determine genetic variation AS. Interaction examined by SNPStats web tool.Results: After adjusting for gender, age, body mass index (BMI),...
Background and Purpose: Endovascular thrombectomy improves the functional independence of patients with proximal anterior circulation occlusion. However, a subset fail to benefit from procedures, reasons for which remain poorly defined. In this study, we investigated whether effectiveness was affected by left- or right-sided occlusion among similar stroke severities. Methods: Patients (internal carotid M1 middle cerebral artery) treated Solitaire stent retriever within 8 h onset acute...
Background Despite the remarkable effectiveness of endovascular treatment (EVT), recent randomized controlled trials indicate that up to half patients with large core infarction have a very poor outcome (modified Rankin Scale score 5–6 at 90 days). This study investigates combined effect Alberta Stroke Program Early CT Score (ASPECTS) and age on in treated EVT. Methods subanalysis MAGIC registry, which is prospective, multicenter cohort early acute stroke, focused ASPECTS ≤5 presenting...
The impact of lowering systolic blood pressure (SBP) following endovascular treatment (EVT) in acute large vessel occlusion stroke (LVOS) patients remains unclear. We aimed to explore the effect magnitude SBP reduction (SBPr) after EVT on outcomes LVOS patients.
Objective To explore the effect of fetal-type posterior cerebral artery (fPCA) on short-term outcomes and degrees severity acute large atherosclerosis (LAA) stroke. Methods A total 689 patients with LAA stroke were consecutively collected from Nanjing Stroke Registry Program (August 2013 to December 2016) database Yijishan Hospital Wannan Medical College (January 2017 2017) according strict inclusion criteria. Patients divided into fPCA group (n=185) non-fPCA (n=504) results 3D-time...
Background Patients with previous stroke episodes tend to have poor outcomes after an endovascular treatment (EVT). Encephalomalacia (EM) is objective indicator of strokes but has not been systematically investigated. The fundamental aim this exploration investigate the effects a pre-existing non-disabling EM on clinical EVT. Methods Consecutive patients undergoing EVT due anterior circulation large vessel occlusion (LVO) were enrolled in study. was defined as focal hypodense lesions (≥ 3 mm...
Abstract Background: Ischemic stroke has high incidence rate, mortality rate and disability rate. Genetic factors have a significant impact on risk. MicroRNAs are class of small non-coding RNA. Intergenic variants can affect the regulation microRNAs modulate large-artery atherosclerosis susceptibility. The low expression miR-451 aggravated ischemic injury significantly. Methods: Functional intergenic near hsa-mir-451 were identified by bioinformatics analysis. We conducted case-control study...