A5100730046- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Obstructive Sleep Apnea Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Gut microbiota and health
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Sodium Intake and Health
- Drug Transport and Resistance Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Biochemical effects in animals
- Protein Hydrolysis and Bioactive Peptides
- Pharmacological Effects of Natural Compounds
- Hedgehog Signaling Pathway Studies
- Ferroptosis and cancer prognosis
- Identification and Quantification in Food
- Liver Diseases and Immunity
- Liver physiology and pathology
- Stress Responses and Cortisol
- Single-cell and spatial transcriptomics
- Neurological Disease Mechanisms and Treatments
- Free Will and Agency
- Treatment of Major Depression
- Lipid metabolism and disorders
- Immune cells in cancer
Zhongshan People's Hospital
2024-2025
Shandong First Medical University
2020-2025
Fujian Provincial Hospital
2024
Fujian Medical University
2024
Liaocheng People's Hospital
2023-2024
Aerospace Information Research Institute
2023
University of Chinese Academy of Sciences
2023
Zhaoqing University
2019-2021
The Sixth People's Hospital of Shenyang
2019
Institute of Process Engineering
2006
Generally, depression is the result of complex gene-environment interactions. Recent studies have showed that gut microbiota can affect brain function through microbiota-gut-brain axis. However, underlying mechanism and potential influence remain elusive. We aimed to determine how microbiome contributes process further influences host. Chronic unpredictable mild stress (CUMS) used establish a model. Fecal transplant (FMT) applied illustrate be transmitted via microbiota, metabolism liver...
Background This study explores the longitudinal relationship between Weight-Adjusted Waist Index (WWI), an innovative obesity metric, and stroke incidence in aged 45 older Chinese adults. Methods Data from 9,725 individuals years were analyzed China Health Retirement Longitudinal Study (2011–2020). Baseline characteristics across different quartiles of WWI. Stroke incidents determined through self-reported doctor diagnoses. Multivariate logistic regression analyses curve fitting assessed...
Objective This study aims to investigate the protective effects of Cordyceps sinensis against renal injury induced by low-dose contrast medium (CM) in coronary computed tomography angiography (CCTA) imaging, and evaluate its efficacy using functional magnetic resonance imaging (fMRI). Methods Twenty Beagle dogs with insufficiency were enrolled randomly assigned one four groups (n = 5 per group). Group A received for 1 week prior undergoing heart rate-dependent personalized CM CCTA scanning;...
The pathogenesis of Alzheimer's disease (AD) is complex and multi-factorial. Increasing evidence has shown the important role immune infiltration in AD. Thus current study was designed to identify infiltration-related genes explore their diagnostic value AD.The expression data AD patients were downloaded from GEO database. limma R package identified differentially expressed (DEGs) between controls. CIBERSORT algorithm infiltrated cells (DIICs) DIIC-correlated DEGs obtained by Pearson...
Abstract α-Enolase ( ENO1 ) is a crucial molecular target for tumor therapy and has emerged as research hotspot in recent decades. Here, we aimed to explore the role of bladder cancer (BLCA) then construct signature predict prognosis treatment response BLCA. Firstly, found was highly expressed BLCA tissues, verified by IHC, associated with poor prognosis. The analysis immune microenvironment bulk RNA-seq scRNA-seq showed that CD8+ T-cell exhaustion. Additionally, results vitro could promote...
Background Stroke-associated pneumonia (SAP) is a common complication of acute ischemic stroke (AIS) and associated with increased mortality prolonged hospital stays. The lymphocyte-to-monocyte ratio (LMR) novel inflammatory marker that has been shown to be various diseases. However, the relationship between LMR SAP in patients AIS remains unclear. Methods A retrospective cohort study was conducted on 1,063 admitted our within 72 hours symptom onset. Patients were divided into two groups:...
1,2,4-Triazoles were synthesized on a solid support in three steps, with excellent yields and purities. The utility of this triazole-functionalized was demonstrated by the solid-phase synthesis various trisubstituted 1,2,4-triazoles.
Carotid atherosclerotic plaques are the manifestation of atherosclerosis in carotid arteries and can significantly increase incidence cerebrovascular disease. Macrophages smooth muscle cells crucial for their development. To reveal mechanism plaque formation, we performed single-nucleus RNA sequencing tissue identified 11 cell types, macrophages were divided into 5 different macrophage subpopulations. The patients with symptomatic caused intraplaque death via mitochondrial autophagic...
Prior research had indicated a relationship between fibrinogen and stroke-associated pneumonia (SAP), yet the nature of this not been thoroughly investigated. Therefore, study was designed to elucidate prognostic value levels in forecasting occurrence SAP among patients with acute ischemic stroke (AIS).
Clinical manifestations of the late-onset adult Pompe disease (glycogen storage type II) are heterogeneous. To identify genetic defects a special patient population with cerebrovascular involvement as main symptom, we performed whole-genome sequencing (WGS) analysis on consanguineous Chinese family total eight members including two siblings both had cerebral infarction. Two novel compound heterozygous variants were found in GAA gene: c.2238G>C exon 16 and c.1388_1406del19 9 patients. We...
A fraction named GFC-1 with high antioxidant activities in vitro was isolated from the enzymatic hydrolysates of roasted pills Asini Corii Colla, and peptides this were identified. The purified anion exchange chromatography Sephadex G-25 filtration successively. GFC-1, a hydrolysates, exhibited highest DPPH ABTS scavenging capacity (DPPH 47. 95% at 2.0 g x L(-1) 97.20% 0.40 L(-1). Nine identified by LC-ESI-MS/MS coupled TurboSEQUEST search software Swiss-Prot data base, repetition core...
<title>Abstract</title> Background Stroke is a leading cause of death and disability globally, with obesity being major risk factor. Traditional measures like Body Mass Index (BMI) waist circumference (WC) have limitations. This study investigates the longitudinal relationship between Weight-Adjusted Waist (WWI), novel measure, stroke incidence in middle-aged elderly Chinese population. Methods prospective cohort utilized data from China Health Retirement Longitudinal Study (CHARLS)...
Aims. To explore the effects of Biejiaxiaozheng pills on carbon tetrachloride-induced hepatic fibrosis in rats through NF-κB/Nrf2 pathway and to possible antifibrotic mechanisms drug. Material Method. A rat model was established via CCl4 induction. Liver function antioxidant indices were detected using commercial kits. Hematoxylin-eosin Masson staining used detect pathological changes tissues. ELISA measure plasma TNF-α, IL-β, IL-6 levels. RT-PCR levels Changes p65, P-p65, Nrf2, HO-1 protein...
In recent years, the UAV light-weighted hyperspectral imaging system has become more available.It can provide high spatial and spectral resolution images for environment monitoring.Mangrove forest interspecies distribution map is important data source government to design protection policy.A research on remote sensing surveying of mangrove implemented in Futian Nature Reserve area located Shenzhen, China.The UAV-based were collected processed get geometrically corrected mosaicked reflectance...
Being opposed to scholars' proposal abolish the death penalty for corrupt government officials, Zhang Guifeng argues that, before effective settlement of three paradoxes existing in China's ineffective struggle against corruption, remains necessary.
Objective To investigate the changes of levels sonic hedgehog (SHH) and vascular endothelial growth factor (VEGF) in serum its relationship with collateral circulation patients symptomatic middle cerebral artery stenosis. Methods From January 2015 to 2018, a total 268 acute ischemic stroke confirmed as unilateral M1 segment (MCA-M1) severe stenosis or occlusion by digital subtract angiography (DSA) were enrolled. The baseline clinical data collected. According establishment shown DSA,...
Objective To observe the clinical efficacy of escitalopram oxalate combined with duloxetine hydrochloride in treatment depression. Methods A total 106 depressive patients treated Sixth People’s Hospital Datong from September 2016 to 2018 were randomly divided into group A and B, 53 cases each group. Patients hydrochloride, while B alone. Effectiveness, Hamilton depression (HAMD) score, anxiety scale (HAMA) score incidence adverse reactions after compared between B. Results After...
Background: Generally, depression is caused by a deficiency in the monoamine transmitters of brain, norepinephrine (NE) and serotonin (5-HT). Recent studies have showed that gut microbiota can affect brain function through microbiota-gut-brain axis. However, underlying mechanism potential influence remain elusive. We aimed to determine how contribute process further host Methods: Fecal transplant (FMT) applied illustrate be transmitted via metabolism serum analysis are demonstrate liver...