A5064668239- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- BRCA gene mutations in cancer
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Gold and Silver Nanoparticles Synthesis and Applications
- Endoplasmic Reticulum Stress and Disease
- Thyroid Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Advanced Nanomaterials in Catalysis
- Nutrition, Genetics, and Disease
- Advanced biosensing and bioanalysis techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple and Secondary Primary Cancers
Fujian Provincial Hospital
2023-2024
Fujian Medical University
2021-2024
Fuzhou University
2024
Jiangxi Provincial Cancer Hospital
2024
Fujian Provincial Cancer Hospital
2021-2022
Sinotech Genomics (China)
2020
Abstract α-Enolase ( ENO1 ) is a crucial molecular target for tumor therapy and has emerged as research hotspot in recent decades. Here, we aimed to explore the role of bladder cancer (BLCA) then construct signature predict prognosis treatment response BLCA. Firstly, found was highly expressed BLCA tissues, verified by IHC, associated with poor prognosis. The analysis immune microenvironment bulk RNA-seq scRNA-seq showed that CD8+ T-cell exhaustion. Additionally, results vitro could promote...
Background Hyaluronan-mediated motility receptor (HMMR) is overexpressed in multiple carcinomas and influences the development treatment of several cancers. However, its role hepatocellular carcinoma (HCC) remains unclear. Methods The “limma” “GSVA” packages R were used to perform differential expression analysis assess activity signalling pathways, respectively. InferCNV was infer copy number variation (CNV) for each hepatocyte “CellChat” analyse intercellular communication networks....
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and outcomes for patients are still poor. It important to determine original type synchronous multinodular HCC preoperative assessment choice treatment therapy as well prediction prognosis after treatment. Aims: To analyze clinicopathologic characteristics prognoses in with multicentric occurrence (MO) intrahepatic metastasis (IM) hepatocellular (HCC). Methods: The study group comprised 42 a total 112...
Background: Aging is a well-studied concept, but no studies have comprehensively analyzed the association between aging-related genes (AGs) and hepatocellular carcinoma (HCC) prognosis. Methods: Gene candidates were selected from differentially expressed prognostic in The Cancer Genome Atlas (TCGA) database. A gene risk score for overall survival prediction was established using least absolute shrinkage selection operator (LASSO) regression analysis, this validated data International...
Kinesin family member 20A (KIF20A) is essential for cell proliferation and implicated in promoting tumor progression, but its role hepatocellular carcinoma (HCC) remains poorly studied.
Methylation is one of the most extensive modifications biological macromolecules and affects cell-fate determination, development, aging, cancer. Several methylation modifications, including 5-methylcytosine N6-methyladenosine, play an essential role in many cancers. However, little known about relationship between prognosis clear cell renal carcinoma (ccRCC). Here, we established a methylation-regulating genes prognostic signature (MRGPS) to predict prognoses ccRCC patients. We obtained...
Background: Tumorigenesis, metastasis, and treatment response of hepatocellular carcinoma (HCC) are regulated by unfolded protein responses (UPR) signaling pathways, including IRE1a, PERK, ATF6, but little is known about UPR related genes with HCC prognosis therapeutic indicators. Objective: We aimed to identify a prognostic signature (UPRRPS) for explore the potential effect current on existing molecular targeted agents immune checkpoint inhibitors (ICIs). Methods: used The Cancer Genome...
Immunotherapy has become a primary and secondary treatment for gastric cancer (GC) patients with mismatch repair deficiency (dMMR), is used in both perioperative advanced stages. The tumor immune microenvironment (TiME) crucial immunotherapy efficacy, yet the impact of MMR status on TiME remains understudied. We employed single-cell RNA sequencing (scRNA-seq) to analyze 33 fresh tissue samples from 25 patients, which included 10 normal tissues, 6 dMMR 17 pMMR aiming characterize cellular...
Abstract Background α-Enolase (ENO1) is a crucial molecular target for tumor therapy and has emerged as research hotspot in recent decades. Here, we aimed to explore the role of ENO1 bladder cancer (BLCA) then construct signature predict prognosis treatment response BLCA. Methods Differential expression, analysis vitro cell experiments were used reveal value The R package "Seurat" was single-cell RNA sequence (scRNA-seq) data processing. “singleR” cellMarker website annotate cells....
Abstract Background Hyaluronan-Mediated Motility Receptor (HMMR) has been demonstrated to be overexpressed in multiple carcinomas and influence the development treatment of several cancers. However, its role hepatocellular carcinoma (HCC) remains unclear. Methods The “limma” package R was used perform differential expression analysis. “GSVA” assess activity signaling pathways, inferCNV infer copy number variation (CNV) for each hepatocyte. “CellChat” analyze intercellular communication...