A5100402590- Autophagy in Disease and Therapy
- Diabetes Management and Research
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Mesenchymal stem cell research
- High Altitude and Hypoxia
- Traditional Chinese Medicine Studies
- Nutrition, Genetics, and Disease
- Thyroid Disorders and Treatments
- Telomeres, Telomerase, and Senescence
- Bone and Joint Diseases
- Artificial Intelligence in Healthcare
- Growth Hormone and Insulin-like Growth Factors
- Glycosylation and Glycoproteins Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Hematopoietic Stem Cell Transplantation
Xuzhou Medical College
2024
Institute of Microbiology
2023
Beijing Proteome Research Center
2021-2022
Universidade Federal do Paraná
2021
Soochow University
2020
Second Affiliated Hospital of Soochow University
2020
Chinese PLA General Hospital
2012-2014
Abstract Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting 3), a outer membrane protein, mitophagy receptor mediates under various stresses, particularly hypoxia, since hypoxia-responsive protein. However, the underlying mechanisms regulate thus mediate hypoxic conditions remain elusive. Here, we demonstrate in hypoxia JNK1/2 (c-Jun...
Hematopoietic disorders are known to increase the risk of complications such as osteoporosis. However, a direct link between hematopoietic cellular and osteoporosis has been elusive. Here, we demonstrate that deterioration autophagy is coupled with in humans. With conditional mouse model which system disrupted by deletion Atg7 gene, show incapacitating causes bone loss perturbs osteocyte homeostasis. Induction osteoporosis, either ovariectomy, blocks estrogen secretion, or injection ferric...
Abstract Hypoxia as a microenvironment or niche stimulates proliferation of neural stem cells (NSCs). However, the underlying mechanisms remain elusive. Autophagy is protective mechanism by which recycled cellular components and energy are rapidly supplied to cell under stress. Whether autophagy mediates NSCs hypoxia how induces unclear. Here, we report that facilitates embryonic NSC through HIF-1/mTORC1 signaling pathway-mediated autophagy. Initially, found greatly induced in NSCs, while...
To investigate the influence of glycemic variability on HbA1c level in elderly male patients with type 2 diabetes (T2DM).The 24-h glucose profiles were obtained using a continuous monitoring system 291 diabetic patients. The relationship between and was assessed these patients.The mean amplitude excursions (MAGE) ≥7.0% significantly higher than <7.0% (4.33±1.67 vs. 3.48±1.46 mmol/L, p<0.001). A simple (Pearson's) correlation analysis indicated that MAGE correlated (r=0.229, Compared lowest...
Chronic high-altitude hypoxia (CHH) induces irreversible abnormalities in various organisms. Emerging evidence indicates that CHH markedly suppresses bone mass and strength. Targeting senescent cells the consequent senescence-associated secretory phenotype (SASP) with senolytics is a recently developed novel therapy for multiple age-related diseases. The combination of dasatinib quercetin (DQ) has been proven to selectively target attenuate SASP tissues. In this study, experimental mice were...
Nocturnal hypoglycemia was a common and serious problem among patients with type 2 diabetes (T2DM), especially in the elderly. This study investigated whether fasting glucose an indicator of nocturnal elderly male T2DM.A total 291 diabetic who received continuous monitoring (CGM) between January 2007 2011 were enrolled study. The association based on CGM data analyzed, comparing bedtime glucose.Based data, had significantly lower (5.88 ± 1.29 versus 6.92 1.32 mmol/L) (7.33 1.70 8.01 1.95...
For hematopoietic stem and progenitor cells (HSPCs), hypoxia is a specific microenvironment known as the hypoxic niche. How regulates erythroid differentiation of HSPCs remains unclear. In this study, we show that evidently accelerates differentiation, autophagy plays pivotal role in process. We further determine mTORC1 signaling suppressed by to relieve its inhibition autophagy, with process activity gradually decreases increases accordingly. Moreover, provide evidence HIF-1 target gene...
By delaying absorption of carbohydrates, acarbose can reduce preprandial hyperglycemia and delay the emergence postprandial hyperglycemia.To evaluate whether shorten desirable time interval between insulin injection meals, 60 elderly (≥60 years) patients with unsatisfactorily controlled type 2 diabetes mellitus despite use were enrolled in a randomized, open-label study 16 weeks' duration. Two groups (n=20 each) randomized to receive isophane protamine biosynthetic human 70/30 injections...
We developed a tandem enrichment strategy combining metabolic labeling-based RNA tagging for selective RBPs purification and HILIC-based simultaneous O-GlcNAcylation phosphorylation profiling.
BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting 3) is a mitochondrial outer membrane that sensitive to hypoxia and mediates mitophagy, process important for quality control maintain energetic redox homeostasis under hypoxia. It has been reported up-regulation of BNIP3, which acts as mitophagy receptor, promotes mitophagy. In our recent study, we found the post-translational modification crucial induce crosstalk between phosphorylation/dephosphorylation ubiquitination switch...