A5101511127- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Bone health and osteoporosis research
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Liver Disease and Transplantation
- Airway Management and Intubation Techniques
- Vitamin D Research Studies
- Liver Diseases and Immunity
- Hormonal and reproductive studies
- Bone Metabolism and Diseases
- Liver Disease Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Bone health and treatments
- Diabetes and associated disorders
- Parathyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Clinical Laboratory Practices and Quality Control
Chinese PLA General Hospital
2012-2024
Shanghai First People's Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Chinese People's Liberation Army
2013-2023
Peking University
2023
Changshu No.1 People's Hospital
2010-2022
People's Liberation Army No. 150 Hospital
2021
University of Science and Technology of China
2021
Chinese General Hospital College of Nursing and Liberal Arts
2019-2020
Tianjin Medical University
2018-2019
The application of metagenomic next-generation sequencing (mNGS) in the diagnosis tuberculous meningitis (TBM) remains poorly characterized. Here, we retrospectively analyzed data from patients with TBM who had taken both mNGS and conventional tests including culture Mycobacterium tuberculosis (MTB), polymerase chain reaction (PCR) acid-fast bacillus (AFB) stain, sensitivity specificity these methods were compared.We recruited admitted to hospital between December 2015 October 2018. first...
Background The triglyceride glucose index (TyG index) has been regarded as a reliable surrogate marker of insulin resistance and an independent predictor diabetes. However, few studies have reported the association between TyG diabetes in elderly population. Accordingly, this study aimed to investigate progression Chinese. Methods Baseline medical history, fasting plasma (FPG), levels during oral tolerance test (OGTT) after 1-hour (1h-PG) 2-hour (2h-PG), (TG) were obtained from cohort 862...
Abstract Two different types of low‐density detergent‐insoluble glycosphingolipid‐enriched membrane domain (DIG) fractions were isolated from myelin by extraction with Triton X‐100 (TX‐100) in 50 mM sodium phosphate buffer at room temperature (20°C) (procedure 1), contrast to a single fraction obtained TX‐100 Tris containing 150 NaCl and 5 EDTA 4°C 2). Procedure 1 has been used the past others for preserve cytoskeleton and/or radial component oligodendrocytes myelin, whereas procedure 2 is...
To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia NGT (HINS), impaired (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM).5 NGT, 25 HINS, IGT, T2DM participated this research. The hyperinsulinemic-euglycemic clamp technique (HECT) was performed all of them to IR levels. relative factors influencing were evaluated. simple sensitivity indices calculated, correlation between each index M value analyzed.The values...
Objective To investigate the relationship between sex hormones and risk of vascular disease in elderly men to evaluate advantages disadvantages testosterone replacement. Methods A total 337 men, aged 60 91 years, were enrolled this single-center, cross-sectional study, their hormone levels assessed. Linear logistic regression analyses utilized compare patients with without disease. The nonparametric K-sample test was used for inter-group comparisons. Results Aging abnormal metabolism both...
The mitochondrial Na(+)/Ca(2+) exchanger, NCLX, plays an important role in the balance between Ca(2+) influx and efflux across inner membrane endothelial cells. Mitochondrial metabolism is likely to be affected by activity of NCLX because activates several enzymes Krebs cycle. It currently believed that mitochondria are not only centers energy production but also sites reactive oxygen species (ROS) generation nucleotide-binding oligomerization domain receptor 3 (NLRP3) inflammasome...
Abstract Severe diseases like cirrhosis and liver failure can be developed from primary biliary cholangitis (PBC). Endothelin-2 (EDN2) endothelin receptor B (EDNRB) are related to the pathogenesis of PBC. However, roles EDN2 EDNRB in PBC-related injury inflammation along with molecular mechanisms poorly defined. In this study, histopathologic alterations tissues were assessed through hematoxylin–eosin staining. Alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate (AST),...
This study aims to compare the effect of repaglinide and metformin among Chinese patients with newly diagnosed diabetes, explore possible mechanisms by which alters insulin secretion.Sixty subjects glycated hemoglobin (HbA1c) < 10.0% were randomly selected receive or monotherapy for 15 weeks. Blood glucose levels, glycemic variability, β-cell function, first-phase secretion compared between these 2 groups at baseline Mouse insulinoma (MIN-6) cells divided into 3 groups: low glucose, high 50...
We aimed to compare the effect of repaglinide and metformin monotherapy as an initial therapy in Chinese patients with newly diagnosed type 2 diabetes mellitus (T2DM).In this 15-week, open-labelled, parallel-controlled, randomised study, 60 drug-naive T2DM were (2:1) receive or monotherapy. Primary endpoint was change HbA1c from baseline end trial. Secondary endpoints included changes glycaemic variability, insulin sensitivity β-cell function.Patients both groups achieved significant...
AimThere have been few reports regarding the association between 1 h-PG concentration and type 2 diabetes mellitus (T2DM) in elderly. This study was performed to assess efficacy of values predicting future risk T2DM elderly.MethodsThe population consisted 928 male volunteers ≥ 55 years old without who were involved a retrospective-prospective cohort over 20 with baseline fasting plasma glucose (FPG) OGTT that included measurement h-PG. The predictive capabilities FPG h-PG, obtained during...
Abstract Background There is growing evidence linking the age-adjusted Charlson comorbidity index (aCCI), an assessment tool for multimorbidity, to fragility fracture and fracture-related postoperative complications. However, role of multimorbidity in osteoporosis has not yet been thoroughly evaluated. We aimed investigate association between aCCI risk older adults at moderate high falling. Methods A total 947 men were included from January 2015 August 2022 a hospital Beijing, China. The was...