A5000841571- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- DNA Repair Mechanisms
- Immune cells in cancer
- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Melanoma and MAPK Pathways
- Mathematical Biology Tumor Growth
- Ginkgo biloba and Cashew Applications
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Medicinal Plants and Neuroprotection
- Head and Neck Surgical Oncology
- Retinoids in leukemia and cellular processes
- thermodynamics and calorimetric analyses
- Endoplasmic Reticulum Stress and Disease
Medanta The Medicity
2025
National Institute of Ayurveda
2025
All India Institute of Medical Sciences
2020-2024
All India Institute of Medical Sciences Raipur
2020-2023
All India Institute of Medical Sciences Bhopal
2020-2023
Gautam Buddha University
2022
DR. B.R.A. Institute Rotary Cancer Hospital
2022
University of Central Lancashire
2014-2016
Royal Preston Hospital
2014-2016
Lancashire Teaching Hospitals NHS Foundation Trust
2015
Bael (A. marmelos) is an important medicinal herb which has been and extensively used in Ayurveda, Siddha other systems. The aim of this study to evaluate the pharmacological activity leaves part plant Aegle marmelos. Ethanolic extract marmelos prepared by successive extraction technique. This research carroed out find Percentage Yield Extract marmelos, determination LD50 EEAML as per OECD guidelines investigate anti-depressant effect using tail suspension test (TST) forced swim (FST)...
Cervical spondylosis is a common spinal problem that seen nowadays. Though degeneration of cervical vertebrae mostly in older adults, its prevalence also increases early or middle age. In the present case study, diagnosed has been included for Ayurvedic management. Chief complaints were pain neck region radiating towards both shoulders, stiffness over 5 to 6 months, and on & off episodes dizziness. The effect oral medication Tab Trayodashanga guggulu, Ekangaveera rasa, Ashwagandharishta,...
Language plays a pivotal role in medicine, influencing clinical decision-making, patient perceptions, and healthcare outcomes. Cognitive linguistics psychology provide crucial insights into how linguistic framing, biases, communication strategies impact medical practice. The framing effect, cognitive biases such as anchoring confirmation bias, the psychological implications of terminology significantly alter both physician decision-making. Additionally, effective doctor-patient fosters trust...
Siglecs belong to a family of immune regulatory receptors predominantly found on hematopoietic cells. They interact with Sia, resulting in the activation or inhibition response. Previous reports have suggested that
Malignant glioma is characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue; hence, diagnosis treatment difficult patient survival poor. Aptamers contribute promising unique technology the in vitro imaging of live cells tissues, with potentially bright future clinical diagnostics therapeutics malignant glioma. The binding selectivity, uptake target two DNA aptamers, SA43 SA44, were investigated tissues. assay showed that SA44 bound strong...
Classical Non-Homologous End Joining (NHEJ) pathway is the mainstay of cellular response to DNA double strand breaks. While aberrant expression genes involved in this has been linked with genomic instability and drug resistance several cancers, limited information available about its clinical significance colon cancer. We performed a comprehensive analysis seven essential genes, including XRCC5, XRCC6, PRKDC, LIG4, XRCC4, NHEJ1 PAXX pathway, cancer using multi-omics datasets, studied their...
Glucocorticoid (GC), such as prednisolone, is an essential component of multidrug chemotherapy regimen for pediatric acute lymphoblastic leukemia (ALL). Resistance to GC in cells associated with disease progression and poor prognosis. Despite the extensive use many years, molecular mechanisms underlying its resistance ALL have not been fully uncovered. Recent studies shown a potential role EMP1, CASP1, NLRP3 genes prednisolone response. In this study on 148 B-ALL patients, we studied these...
Prothymosin-α (PTMA), a nuclear protein, is strikingly associated with unfavorable clinical outcomes in many cancers. However, no information about its relevance glioma was available. Therefore the present study, we evaluated prognostic utility of this protein cohort 81 patients. The PTMA expression assessed by immunohistochemical analysis, quantitative PCR, and Western blotting. Furthermore, association clinicopathological features molecular alterations were patient validated multiomics...
Abstract T-acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignancy characterized by the abnormal proliferation of immature T-cell precursors. Despite advances in immunophenotypic classification, understanding molecular landscape and its impact on patient prognosis remains challenging. In this study, we conducted comprehensive RNA sequencing cohort 35 patients with T-ALL to unravel intricate transcriptomic profile. Subsequently, validated prognostic relevance 23 targets,...
Melanoma associated antigen (MAGE) is an extensively studied family of tumor-associated genes that share a common MAGE homology domain (MHD). Based upon their expression pattern, have been broadly classified into type 1 MAGEs (T1Ms) and 2 (T2Ms) categories. Interestingly, several T2Ms are highly expressed in the brain involved regulation neuronal development, differentiation, survival. Available literature suggests possible tumor suppressor functions few T2Ms, while information available...
Hepatocellular carcinoma (HCC) is an aggressive gastrointestinal malignancy with a high rate of mortality. Multiple studies have individually recognized members RAP gene family as critical regulators tumor progression in several cancers, including hepatocellular carcinoma. These suffer numerous limitations small sample size and lack analysis various clinicopathological molecular features. In the current study, we utilized authoritative multi-omics databases to determine association...
T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease, characterized by an abnormal transformation of T cells into highly proliferative leukemic lymphoblasts. Identification common genetic alterations has provided promising opportunities for better risk stratification in T-ALL. Current treatment T-ALL still poses the major challenge integrating knowledge molecular clinical setting. We utilized Multiplex Ligation Dependent Probe Amplification (MLPA) method to...
Resistance to therapy in esophageal squamous cell carcinoma (ESCC) is a critical clinical problem and identification of novel therapeutic targets highly warranted. Dipeptidyl peptidase III (DPP3) zinc-dependent aminopeptidase functions the terminal stages protein turnover. Several studies have reported overexpression oncogenic DPP3 numerous malignancies. The present study aimed determine expression pattern functional role ESCC. was assessed normal tumor tissues using quantitative real-time...
Depression is a prevalent mental illness. In addition to being substantial contribution the overall global disease burden, depression one of main causes disability worldwide. Complementary therapies are necessary because drawbacks standard antidepressant therapy, including side effects, even though former can help reduce symptoms and avoid relapse Because they have fewer effects less expensive than other for depression, herbal medications drawn lot interest recently. Compared synthetic...
Cysteine cathepsins are lysosomal proteases that require Cys-His ion pair in their catalytic site for enzymatic activity. While aberrant expression and oncogenic functions have been widely reported solid tumors, recent findings suggest these also play an important role the pathogenesis of hematological malignancies. In this review, we summarize potential clinical implications cysteine as diagnostic prognostic markers leukemia, present evidences which supports utility therapeutic targets We...
The molecular heterogeneity of T-cell acute lymphoblastic leukemia (T-ALL) makes this disease complex. Early precursor ALL (ETP-ALL) is a recognized subtype T-ALL associated with high probability induction failure conventional therapy. Higher expression myocyte enhancer factor 2C (MEF2C) and the absence biallelic deletion (ABD) are designated markers for ETP-ALL. Co-deletion contiguous genes cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) methylthioadenosine phosphorylase (MTAP) cluster,...