A5053501713- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Immune Response and Inflammation
- RNA modifications and cancer
- Lymphatic System and Diseases
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- S100 Proteins and Annexins
- Proteoglycans and glycosaminoglycans research
- Advanced Glycation End Products research
- Streptococcal Infections and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Carbohydrate Chemistry and Synthesis
- Peptidase Inhibition and Analysis
- Forensic and Genetic Research
- Milk Quality and Mastitis in Dairy Cows
- Sympathectomy and Hyperhidrosis Treatments
- Phytochemicals and Antioxidant Activities
- Flavonoids in Medical Research
- Chronic Kidney Disease and Diabetes
- RNA Research and Splicing
- Escherichia coli research studies
University of Hertfordshire
2022-2024
American University of Ras Al Khaimah
2019-2021
University of California, San Diego
2014-2021
University of Lausanne
2012
École Polytechnique Fédérale de Lausanne
2012
ETH Zurich
2012
First-generation immune checkpoint inhibitors, including anti-CTLA-4 and anti-programmed death 1 (anti-PD-1) antibodies, have led to major clinical progress, yet resistance frequently leads treatment failure. Thus, new targets acting on T cells are needed. CD33-related sialic acid-binding immunoglobulin-like lectins (Siglecs) pattern-recognition receptors binding a range of sialoglycan ligands, which appear function as self-associated molecular patterns (SAMPs) that suppress autoimmune...
Significance In vitro and in vivo data indicate that hypersialylated tumor cells can engage Siglec-9 on myelomonocytic influence the outcome of interaction, depending stage growth microenvironment. On one hand, engagement or Siglec-E by tumor-associated ligands inhibited immunosurveillance cell killing during establishment autologous tumors new metastatic foci. other inhibition macrophages through led to M1 polarization reduced growth-promoting inflammation within This demonstrates a...
Rationale: Lymphatic vasculature plays important roles in tissue fluid homeostasis maintenance and the pathology of human diseases. Yet, molecular mechanisms that control lymphatic vessel maturation remain largely unknown. Objective: We analyzed gene expression profiles ex vivo isolated endothelial cells to identify novel expressed genes we investigated role semaphorin 3A (Sema3A) neuropilin-1 (Nrp-1) function. Methods Results: blood vascular from mouse intestine were using...
The immunomodulatory receptor Siglec-3/CD33 influences risk for late-onset Alzheimer's disease (LOAD), an apparently human-specific post-reproductive disease. CD33 generates two splice variants: a full-length CD33M transcript produced primarily by the "LOAD-risk" allele and shorter CD33m isoform lacking sialic acid-binding domain from "LOAD-protective" allele. An SNP that modulates splicing to favor is associated with enhanced microglial activity. Individuals expressing more protective...
Significance Platelets have an important role in blood clotting, but also function immune responses, including the release of antimicrobial peptides that eliminate pathogens such as Staphylococcus aureus . Here we observe group B Streptococcus (GBS), a leading cause sepsis and meningitis human newborns, is not killed by platelets. The key to GBS platelet resistance polysaccharide capsule coats bacterial surface contains sialic acid (Sia), common sugar present on all cells. Sia blocks...
Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics such as Siglec-15. Presently, small molecule targeting Siglec-15 not explored alongside characterised regulatory mechanisms involving microRNAs CRC progression. Therefore, inhibitor to target was elucidated vitro and microRNA mediated effects were investigated. Our research findings demonstrated that the SHG-8 exerted significant...
CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding sialylated glycans or other ligands triggers signals that inhibit activate inflammation. Immunomodulation by has been extensively studied, but relationships between structure and functions poorly explored. Here we present new data relating to the function Siglec-E, major Siglec mouse neutrophils, monocytes, macrophages, dendritic We generated nine rat monoclonal antibodies specific with no...
Siglecs belong to a family of immune regulatory receptors predominantly found on hematopoietic cells. They interact with Sia, resulting in the activation or inhibition response. Previous reports have suggested that
Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The SIGLEC12 gene, which encodes the Siglec-XII protein expressed on epithelial cells, has several uniquely human features: a fixed homozygous missense mutation inactivating its natural ligand recognition property; polymorphic frameshift eliminating full-length expression in ~60%–70% of worldwide populations; and, genomic features suggesting negative...
Human metabolic incorporation of nonhuman sialic acid (Sia) N-glycolylneuraminic into endogenous glycans generates inflammation via preexisting antibodies, which likely contributes to red meat–induced atherosclerosis acceleration. Exploring whether this mechanism affects in end-stage renal disease (ESRD), we instead found serum accumulation 2-keto-3-deoxy-d-glycero-d-galacto-2-nonulosonic (Kdn), a Sia prominently expressed cold-blooded vertebrates. In patients with ESRD, levels the Kdn...
Significance Sepsis is a condition wherein microbial infection leads to life-threatening systemic hyperactivation of innate immunity. Blood pH normally maintained tightly between 7.35 and 7.45, lactic acidosis with <7.3 indicates poor prognosis in sepsis, also associated low zinc levels. Release HMGB1 from activated and/or necrotic tissues plays pivotal role triggering the proinflammatory cascade late sepsis. Using an vitro whole-blood assay, we observed that cannot mediate activity at...
Targeting cell cycle and inducing DNA damage by activating death pathways are considered as effective therapeutic strategy for combating breast cancer progression. Many of the naturally known small molecules target these signaling against resistant and/or aggressive types cancers. Here, we investigated effect catechol, a occurring plant compound, its specificity chemotherapeutic efficacies in (MCF‐7 MDA‐MB‐231) cells. Catechol treatment showed concentration‐dependent cytotoxicity...
Glioblastoma (GB) is an aggressive brain malignancy characterized by its invasive nature. Current treatment has limited effectiveness, resulting in poor patients' prognoses. β-Amino carbonyl (β-AC) compounds have gained attention due to their potential anticancerous properties.