A5055922942- Protein Structure and Dynamics
- Lipid Membrane Structure and Behavior
- RNA and protein synthesis mechanisms
- Influenza Virus Research Studies
- Photoreceptor and optogenetics research
- Advanced NMR Techniques and Applications
- Receptor Mechanisms and Signaling
- Spectroscopy and Quantum Chemical Studies
- Computational Drug Discovery Methods
- interferon and immune responses
- Glycosylation and Glycoproteins Research
- Ion Transport and Channel Regulation
- Solid-state spectroscopy and crystallography
- Mass Spectrometry Techniques and Applications
- Supramolecular Self-Assembly in Materials
- DNA and Nucleic Acid Chemistry
- Biochemical Analysis and Sensing Techniques
- Plant Stress Responses and Tolerance
- Monoclonal and Polyclonal Antibodies Research
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Advanced biosensing and bioanalysis techniques
- Nanopore and Nanochannel Transport Studies
- Analytical Chemistry and Sensors
- Bacteriophages and microbial interactions
University of Hertfordshire
2014-2025
University of Warwick
2002-2008
Coventry University
2006
National Institute of Chemical Physics and Biophysics
2004
University of Oxford
2004
University of Cambridge
1999-2001
Bielefeld University
1993-1998
United-atom force fields for molecular dynamics (MD) simulations provide a higher computational efficiency, especially in lipid membrane simulations, with little sacrifice accuracy, when compared to all-atom fields. Excellent united-atom models are available, but combination depreciated protein In this work, model of the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine has been built standard parameters field GROMOS96 53a6 that reproduces experimental area per bilayer within 3% accuracy value...
Detailed site-specific information can be exceptionally useful in structural studies of macromolecules general and proteins particular. Such is usually obtained from spectroscopic using a label/probe that reflect on particular properties the protein. A suitable probe must not modify native protein, should yield interpretable information, as case with isotopic labels used by Fourier transform infrared (FTIR) spectroscopy. In particular, 1-13CO have been shown to relay secondary structure...
17O solid-state NMR from 14 amino acids is reported here, greatly increasing the number investigated. In most cases well-separated resonances carbonyl and hydroxyl oxygens with distinct second-order quadrupolar line shapes are observed using a 600 MHz spectrometer fast magic angle spinning (MAS). This in contrast to motionally averaged usually seen solution. For double-angle rotation (DOR) produces decrease width by more than factor of 40, providing very high resolution, ∼1 ppm, spectra. The...
The non-structural protein 1 (NS1) of the influenza A virus and NS2 protein, which is also known as nuclear export play important roles in infectious life cycle virus. objective this study was to find degree conservation NS proteins identify conserved sites functional or structural importance that may be utilized potential drug target sites. analysis based on 2620 amino acid sequences for NS1 1195 protein. binding were mapped onto structures obtained from a combination experimentally...
Human phospholemman (PLM) is a 72-residue protein, which expressed at high density in the cardiac plasma membrane and various other tissues. It forms ion channels selective for K+, Cl-, taurine lipid bilayers colocalizes with Na+/K+-ATPase Na+/Ca2+-exchanger, may suggest role regulation of cell volume. Here we present first structural data based on synthetic peptides representing transmembrane domain PLM. Perfluoro-octaneoate-PAGE reconstituted proteoliposomes containing PLM reveals...
Glioblastoma (GB) is an aggressive brain malignancy characterized by its invasive nature. Current treatment has limited effectiveness, resulting in poor patients' prognoses. β-Amino carbonyl (β-AC) compounds have gained attention due to their potential anticancerous properties.
The 115-residue protein CM2 from Influenza C virus has been recently characterized as a tetrameric integral membrane glycoprotein. Infrared spectroscopy and site-directed infrared dichroism were utilized here to determine its transmembrane structure. domain of is alpha-helical, the helices are tilted by beta = (14.6 +/- 3.0) degrees normal. rotational pitch angle about helix axis omega for 1-(13)C-labeled residues Gly(59) Leu(66) (218 17) degrees, where defined zero residue pointing in...