A5041798258- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Lipid Membrane Structure and Behavior
- Probiotics and Fermented Foods
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- Nanoparticles: synthesis and applications
- X-ray Diffraction in Crystallography
- Protein Structure and Dynamics
- Microbial Natural Products and Biosynthesis
- Ion channel regulation and function
- Biochemical and Structural Characterization
- Biochemical and Molecular Research
- Microbial Metabolites in Food Biotechnology
- Cell Adhesion Molecules Research
- Listeria monocytogenes in Food Safety
- Bacillus and Francisella bacterial research
- ATP Synthase and ATPases Research
- Artificial Intelligence in Healthcare and Education
- Viral gastroenteritis research and epidemiology
Sathyabama Institute of Science and Technology
2015-2025
Madurai Kamaraj University
2024
Institute for Stem Cell Biology and Regenerative Medicine
2024
Manipal Academy of Higher Education
2024
Institute of Bioinformatics
2024
National University Health System
2013-2015
National University of Singapore
2013-2015
Yong In University
2015
Nanyang Technological University
2005-2014
The envelope (E) protein from coronaviruses is a small polypeptide that contains at least one α-helical transmembrane domain. Absence, or inactivation, of E results in attenuated viruses, due to alterations either virion morphology tropism. Apart its morphogenetic properties, has been reported have membrane permeabilizing activity. Further, the drug hexamethylene amiloride (HMA), but not amiloride, inhibited vitro ion channel activity some synthetic coronavirus proteins, and also viral...
The coronavirus responsible for the severe acute respiratory syndrome (SARS-CoV) contains a small envelope protein, E, with putative involvement in host cell apoptosis and virus morphogenesis. It has been suggested that E protein can form membrane destabilizing transmembrane (TM) hairpin, or homooligomerize to regular TM alpha-helical bundle. We have shown previously topology of domain (ETM), flanked by two lysine residues at C N termini improve solubility, is consistent alpha-helix,...
The F1 FO -ATP synthase is required for growth and viability of Mycobacterium tuberculosis a validated clinical target. A mycobacterium-specific loop the enzyme's rotary γ subunit plays role in coupling ATP synthesis within enzyme complex. We report discovery novel antimycobacterial, termed GaMF1, that targets this loop. Biochemical NMR studies show GaMF1 inhibits activity by binding to bactericidal active against multidrug- as well bedaquiline-resistant strains. Chemistry efforts on...
Bacterial identification is vital for healthcare and environmental quality control. Traditional bacterial methods require extensive sample preparation, including cultivation, staining, microscopy, making them time-consuming labor-intensive. This study proposes the application of Laser Speckle Contrast Imaging (LSCI) as a novel approach to capture variations in speckle patterns between start end lag caused by changes shape arrangement cells during cell division liquid cultures at lower...
In this study, we systematically examine how the nature of protein corona on NPs, formed from either antibody or antigen, and number binding sites epitopes antigen affect aggregation.
Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis (M. tuberculosis). WHO estimated that 10.4 million new (incident) TB cases worldwide in year 2016. The increased prevalence of drug resistant strains and side effects associated with the current anti-tubercular drugs make treatment options more complicated. Hence, there are necessities to identify candidates fight against various sub-populations M. less or no toxicity/side shorter duration. Bacteriocins produced...
Abstract Integrins are α/β heterodimers, but recent in vitro and vivo experiments also suggest an ability to associate through their transmembrane domains form homomeric interactions. While the results of some consistent with interaction mediated by a GxxxG‐like motif, homo‐oligomers observed after cross‐linking almost opposite helix–helix interface. We have shown recently that both models compatible evolutionary conservation data, we predicted α‐helices would similar rotational orientation....
Abstract The F 1 O ‐ATP synthase is required for growth and viability of Mycobacterium tuberculosis a validated clinical target. A mycobacterium‐specific loop the enzyme's rotary γ subunit plays role in coupling ATP synthesis within enzyme complex. We report discovery novel antimycobacterial, termed GaMF1, that targets this loop. Biochemical NMR studies show GaMF1 inhibits activity by binding to bactericidal active against multidrug‐ as well bedaquiline‐resistant strains. Chemistry efforts...
Biosynthesis of silver nanoparticles (AgNPs) has been performed using various sources including plants and fungi. Sargassum swartzii is an alga that a vast spectrum biological activities predominantly found on the Indian coasts. In this study, AgNPs was biosynthesized S. evaluated for its antibacterial potency against Escherichia coli (ATCC 25922). The synthesized (NPs) were imaged TEM analyses to be spherical crystalline with size around 20–40 nm. Zeta sizing analysis revealed mean particle...