A5057766780- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
- Radiation Effects and Dosimetry
- Antibiotics Pharmacokinetics and Efficacy
- Electrolyte and hormonal disorders
- Analytical Chemistry and Chromatography
- Magnolia and Illicium research
- Anesthesia and Sedative Agents
- Nutrition and Health in Aging
- Tea Polyphenols and Effects
- Analytical chemistry methods development
- Skin Protection and Aging
- Luminescence Properties of Advanced Materials
- Curcumin's Biomedical Applications
- Thermal and Kinetic Analysis
- Oxidative Organic Chemistry Reactions
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- melanin and skin pigmentation
- Drug Solubulity and Delivery Systems
- Telomeres, Telomerase, and Senescence
- Safe Handling of Antineoplastic Drugs
- Diet and metabolism studies
- Analytical Methods in Pharmaceuticals
Poznan University of Medical Sciences
2013-2024
Glioblastoma (GBM) is an extremely invasive and heterogenous malignant brain tumor. Despite advances in current anticancer therapy, treatment options for glioblastoma remain limited, tumor recurrence inevitable. Therefore, alternative therapies or new active compounds that can be used as adjuvant therapy are needed. This study aimed to develop, optimize, characterize honokiol-loaded nanoemulsions intended intravenous administration therapy.Honokiol-loaded nanoemulsion was developed by...
Cancer is a leading cause of death worldwide, and the effectiveness treatment consistently not at satisfactory level. This review thoroughly examines present knowledge perspectives honokiol (HON) in cancer therapeutics. The paper synthesizes critical insights into molecular mechanisms underlying observed anticancer effects, emphasizing both vitro vivo studies. effects HON application, primarily common types cancers, are presented. Because therapeutic potential may be limited by its...
Background: Parenteral nutrition (PN) is a lifesaving therapeutic approach for patients unable to meet nutritional needs through oral or enteral routes. Lipid nanoemulsions (NEs), critical component of PN, provide essential fatty acids and influence the formulation’s physicochemical properties. Advances in drug delivery systems have led novel intravenous NEs with improved stability, purity, ability nutrient/active substance delivery. Due scattered information lack standardized protocol...
Background: Glioblastoma (GBM) is the most frequently occurring primary malignant central nervous system tumor, with a poor prognosis and median survival below two years. Administration of combination non-steroidal anti-inflammatory drugs natural compounds that exhibit curative or prophylactic effect in cancer new approach to GBM treatment. This study aimed investigate synergistic antitumor activity etoricoxib (ETO) cannabidiol (CBD) cell line model, develop poly(lactic-co-glycolic acid)...
The group of patients most frequently in need nutritional support are intensive care patients. This year (i.e., 2019), new European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines clinical nutrition were published, updating gathering current knowledge on the subject this Planning right intervention is often a challenging task involving necessity choice enteral (EN) or parenteral (PN) route administration, time initiation, energy demand, amino acid content demand as well use...
In the United States, annual incidence of bladder cancer is approximately 70,000 new cases, with a mortality rate 15,000/year. The most common subtype (70%) superficial, namely hte non-muscle invasive disease form limited to urothelium. progression and recurrence up 40 70%, respectively. Urothelial cell carcinoma typically treated transurethral resection. cancerous cells can float onto adjacent epithelium, increasing risk recurrence. standard care offer adjuvant intravesical agents reduce...
A serious problem in everyday clinical practice is the co-administration of drugs using same infusion line. Potential complications incompatible include precipitation line or central venous catheter leading to its occlusion. Administration precipitate and large lipid droplets into system may lead embolization capillaries local systemic inflammatory reactions, with consequences thrombosis, chronic insufficiency, even pulmonary embolism. The must always be confirmed clearly defined. study...
Improvement of the bioavailability poorly soluble medicinal substances is currently one major challenges for pharmaceutical industry. Enhancing dissolution rate those drugs using novel methods allows to increase their bioavailability. In recent years, silica-based mesoporous materials have been proposed as drug delivery systems that augment rate. The aim this study was analyse influence phenylbutazone adsorption on SBA-15 its Moreover, we examined cytotoxicity analyzed silica. material...
Background: Ampicillin (AMP) is frequently administered parenterally in critically ill patients with meningitis or endocarditis. Many of them require parallel infusion total parenteral nutrition (TPN) admixtures. The aim the study was to determine physicochemical stability AMP TPN Methods: added two formulations admixtures differing lipid emulsion (Lipofundin® MCT/LCT 20% LIPIDem®). Samples were stored at 4 ± 1 °C light protection, and 25 without protection assess impact temperature on...
Patients referred to intensive care units (ICU) require special due their life-threatening condition, diseases and, frequently, malnutrition. Critically ill patients manifest a range of typical physiological changes caused by predominantly catabolic reactions in the body. It is necessary provide with proper nutrition, for example administering total parenteral nutrition (TPN). The addition linezolid TPN mixtures treated linezolid-sensitive infections may reduce extent vascular access...
Epilepsy is defined as a group of concerning problems related to the nervous system; its defining feature predisposition epileptic seizures. The frequency seizures in intensive care units (ICU) ranges from 3.3% 34%, and ICU antiepileptic treatment routine practice. administration drugs through same infusion line not recommended but common clinical practice, especially ICU. Incompatibilities between parenteral nutrition admixtures (PNAs) are medical errors pose risks patient safety....
Co-infusion of parenteral nutrition (PN) and other drugs increases the risk interaction between drug PN admixtures that can cause embolization small blood vessels, resulting in potentially fatal consequences, including pulmonary embolism, or liver retina vascular damage. The present study aimed to determine compatibility ciprofloxacin (CF) eighteen compounded order assess possibility their co-administration via Y-sites. CF were mixed at two volume ratios (1:1 2:1) potential interactions...
Curcumin is a well-known and widely used substance of natural origin. It has also been found to be helpful in the treatment liver diseases. Unfortunately, curcumin very low bioavailability sensitivity external agents. Improving these parameters subject many studies. One way overcome problems may use Phosal® as source encapsulate this dispersion into nanoemulsion using different types concentrations surfactants co-surfactants, thus manipulating physicochemical nanoemulsion. The present study...