A5035615145- Curcumin's Biomedical Applications
- Magnolia and Illicium research
- Synthesis and biological activity
- Biochemical effects in animals
- Retinoids in leukemia and cellular processes
- Porphyrin and Phthalocyanine Chemistry
- Ginkgo biloba and Cashew Applications
- Pharmacological Effects of Natural Compounds
- Carbohydrate Chemistry and Synthesis
- Phytochemicals and Antioxidant Activities
- Photodynamic Therapy Research Studies
- PARP inhibition in cancer therapy
- Tea Polyphenols and Effects
- Synthesis of Organic Compounds
- Synthesis and Reactions of Organic Compounds
- RNA Interference and Gene Delivery
- Oxidative Organic Chemistry Reactions
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Medicinal Plants
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Lipid metabolism and disorders
- Cannabis and Cannabinoid Research
- Nanoplatforms for cancer theranostics
- Diabetes Management and Research
Poznan University of Medical Sciences
2020-2025
Glioblastoma (GBM) is an extremely invasive and heterogenous malignant brain tumor. Despite advances in current anticancer therapy, treatment options for glioblastoma remain limited, tumor recurrence inevitable. Therefore, alternative therapies or new active compounds that can be used as adjuvant therapy are needed. This study aimed to develop, optimize, characterize honokiol-loaded nanoemulsions intended intravenous administration therapy.Honokiol-loaded nanoemulsion was developed by...
Although curcumin is a well-known natural polyphenol with many biological activities, its clinical application has been limited by low aqueous solubility and stability. Therefore, derivatives have proposed to overcome these limitations increase anticancer activity. This study tested modified feruloyl moieties (2a 2a-B) the β-diketo moiety (2a-B) better understand their mechanism against human bladder cancer cells. The activity of 2a 2a-B was determined using MTT (hypoxic conditions) LDH...
Abstract Cancers present a significant medical problem despite the development of and pharmaceutical sciences leading to search for further therapeutic approaches. One such approach could involve use curcumin or its derivatives. Curcumin reveals interesting antineoplastic effects that help in treatment cancer diseases. However, this natural product possesses some limitations which prevent application medicine. Among limitations, it is characterized by poor water solubility, low stability,...
Curcumin has been modified in various ways to broaden its application medicine and address limitations. In this study, we present a series of curcumin-based derivatives obtained by replacing the hydroxy groups feruloyl moiety with polyethylene glycol (PEG) chains addition BF2 carbonyl groups. Tested compounds were screened for their cytotoxic activity toward two bladder cancer cell lines, 5637 SCaBER, noncancerous line derived from lung fibroblasts (MRC-5). Cell viability was analyzed under...
Background: Glioblastoma (GBM) is the most frequently occurring primary malignant central nervous system tumor, with a poor prognosis and median survival below two years. Administration of combination non-steroidal anti-inflammatory drugs natural compounds that exhibit curative or prophylactic effect in cancer new approach to GBM treatment. This study aimed investigate synergistic antitumor activity etoricoxib (ETO) cannabidiol (CBD) cell line model, develop poly(lactic-co-glycolic acid)...
This work presents the synthesis and characterization of metal-free, zinc (II), cobalt (II) porphyrins substituted with short PEG chains. The synthesized compounds were characterized by UV-Vis, 1H 13C NMR spectroscopy, MALDI-TOF mass spectrometry. origin absorption bands for tested in UV-Vis range was determined using a computational model based on electron density functional theory (DFT) its time-dependent variant (TD-DFT). photosensitizing activity evaluated measuring ability to generate...
Low efficiency of anticancer drugs and their toxicity in normal tissues has motivated further study on safe effective modern agents. In the presented study, design synthesis a library 14 fluorinated curcumin (F-CUR) derivatives F-CUR-BF2 adducts are presented. Chemical modifications included introduction BF2 unit to diketone group, as well substitutions one or two fluorine atoms different positions phenyl rings. The obtained compounds were broadly characterized using ESI HRM spectrometry, 1D...
Intestinal failure-associated liver disease (IFALD) is a severe injury occurring due to factors related intestinal failure and parenteral nutrition administration. Different approaches are studied reduce the risk or ameliorate course of IFALD, including providing omega-3 fatty acids instead soybean oil-based lipid emulsion administering active compounds that exert hepatoprotective effect. This study aimed develop, optimize, characterize magnolol-loaded intravenous for nutrition. The...
Two novel fluorocurcumin adducts with a difluoroboryl group exhibited activity in vitro against two bladder cancer cell lines, namely 5637 and SCaBER. The stability was evaluated under physiologically relevant conditions to mimic both the digestive tract environment. Therefore, experiments were performed hydrochloric acid at pH 1.2, buffer solutions from 4.5 6.8 37°C. A validated HPLC method, allowing monitoring of changes substrates products concentrations over time, applied. Notably, main...