A5054252344- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
- Antibiotics Pharmacokinetics and Efficacy
- Liver Disease Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Safe Handling of Antineoplastic Drugs
- Magnolia and Illicium research
- Pharmacological Effects of Natural Compounds
- Cannabis and Cannabinoid Research
- Nutrition and Health in Aging
- Oxidative Organic Chemistry Reactions
- Skin Protection and Aging
- Diet, Metabolism, and Disease
- Electrolyte and hormonal disorders
- melanin and skin pigmentation
- Telomeres, Telomerase, and Senescence
- Antioxidant Activity and Oxidative Stress
- Drug-Induced Hepatotoxicity and Protection
- Frailty in Older Adults
- Phytochemicals and Antioxidant Activities
- Tissue Engineering and Regenerative Medicine
- Poisoning and overdose treatments
- Pancreatic function and diabetes
- Neonatal Health and Biochemistry
- Genomics, phytochemicals, and oxidative stress
Poznan University of Medical Sciences
2015-2025
Heliodor Swiecicki Clinical Hospital
2019-2020
Université de Lorraine
2015
Glioblastoma (GBM) is an extremely invasive and heterogenous malignant brain tumor. Despite advances in current anticancer therapy, treatment options for glioblastoma remain limited, tumor recurrence inevitable. Therefore, alternative therapies or new active compounds that can be used as adjuvant therapy are needed. This study aimed to develop, optimize, characterize honokiol-loaded nanoemulsions intended intravenous administration therapy.Honokiol-loaded nanoemulsion was developed by...
Cancer is a leading cause of death worldwide, and the effectiveness treatment consistently not at satisfactory level. This review thoroughly examines present knowledge perspectives honokiol (HON) in cancer therapeutics. The paper synthesizes critical insights into molecular mechanisms underlying observed anticancer effects, emphasizing both vitro vivo studies. effects HON application, primarily common types cancers, are presented. Because therapeutic potential may be limited by its...
Background: Intravenous nanoemulsions (NEs) are gaining attention as potential delivery systems for poorly water-soluble substances like cannabidiol (CBD). This study aimed to develop novel NEs based on CBD-enriched hemp oils and evaluate their physiochemical properties. Methods: The stability of enriched with various concentrations CBD (0.5%, 1.0%, 1.5%) without the addition α-tocopherol was determined, most stable were subsequently incorporated into NEs. In order determine content in...
Background: Parenteral nutrition (PN) is a lifesaving therapeutic approach for patients unable to meet nutritional needs through oral or enteral routes. Lipid nanoemulsions (NEs), critical component of PN, provide essential fatty acids and influence the formulation’s physicochemical properties. Advances in drug delivery systems have led novel intravenous NEs with improved stability, purity, ability nutrient/active substance delivery. Due scattered information lack standardized protocol...
Background: Glioblastoma (GBM) is the most frequently occurring primary malignant central nervous system tumor, with a poor prognosis and median survival below two years. Administration of combination non-steroidal anti-inflammatory drugs natural compounds that exhibit curative or prophylactic effect in cancer new approach to GBM treatment. This study aimed investigate synergistic antitumor activity etoricoxib (ETO) cannabidiol (CBD) cell line model, develop poly(lactic-co-glycolic acid)...
The group of patients most frequently in need nutritional support are intensive care patients. This year (i.e., 2019), new European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines clinical nutrition were published, updating gathering current knowledge on the subject this Planning right intervention is often a challenging task involving necessity choice enteral (EN) or parenteral (PN) route administration, time initiation, energy demand, amino acid content demand as well use...
A serious problem in everyday clinical practice is the co-administration of drugs using same infusion line. Potential complications incompatible include precipitation line or central venous catheter leading to its occlusion. Administration precipitate and large lipid droplets into system may lead embolization capillaries local systemic inflammatory reactions, with consequences thrombosis, chronic insufficiency, even pulmonary embolism. The must always be confirmed clearly defined. study...
Background: Ampicillin (AMP) is frequently administered parenterally in critically ill patients with meningitis or endocarditis. Many of them require parallel infusion total parenteral nutrition (TPN) admixtures. The aim the study was to determine physicochemical stability AMP TPN Methods: added two formulations admixtures differing lipid emulsion (Lipofundin® MCT/LCT 20% LIPIDem®). Samples were stored at 4 ± 1 °C light protection, and 25 without protection assess impact temperature on...
Co-infusion of parenteral nutrition (PN) and other drugs increases the risk interaction between drug PN admixtures that can cause embolization small blood vessels, resulting in potentially fatal consequences, including pulmonary embolism, or liver retina vascular damage. The present study aimed to determine compatibility ciprofloxacin (CF) eighteen compounded order assess possibility their co-administration via Y-sites. CF were mixed at two volume ratios (1:1 2:1) potential interactions...
Curcumin is a well-known and widely used substance of natural origin. It has also been found to be helpful in the treatment liver diseases. Unfortunately, curcumin very low bioavailability sensitivity external agents. Improving these parameters subject many studies. One way overcome problems may use Phosal® as source encapsulate this dispersion into nanoemulsion using different types concentrations surfactants co-surfactants, thus manipulating physicochemical nanoemulsion. The present study...
Intestinal failure-associated liver disease (IFALD) is a severe injury occurring due to factors related intestinal failure and parenteral nutrition administration. Different approaches are studied reduce the risk or ameliorate course of IFALD, including providing omega-3 fatty acids instead soybean oil-based lipid emulsion administering active compounds that exert hepatoprotective effect. This study aimed develop, optimize, characterize magnolol-loaded intravenous for nutrition. The...
Fabrication of scaffolds loaded with nitric oxide (NO) donors (S-nitrosoglutathione, GSNO, and isosorbide mononitrate, ISMN) suitable cell compatibility optimized properties for tissue-engineering applications is reported using "in situ" technique. Based on FDA-approved polymer, solvent dosage forms, this gentle process allowed the incorporation GSNO labile drug into made either poly(lactide-co-glycolide) (PLGA) or PLGA/poly(ɛ-caprolactone) (PCL) blend. During manufacturing including washing...
Simultaneous administration of parenteral nutrition (PN) admixtures with intravenous antibiotics is a common clinical problem. Coadministration drugs incompatible PN admixture may affect its stability, especially in the context lipid droplet size, which crucial parameter for patient safety. In present study, we investigate vitro compatibility meropenem (Meropenem 1000, MPM) five commercial used worldwide: Kabiven, Olimel N9E, Nutriflex Lipid Special, Omega and SmofKabiven. The appropriate...
Intravenous drug incompatibilities are a common cause of medical errors, contributing to ineffective therapy and even life-threatening events. The co-administration drugs must always be supported by studies confirming compatibility thus guarantee the therapy’s safety. Particular attention should paid possible or degradation intravenous cephalosporins in different infusion regimens since administration with inadequate quality may treatment failure. Therefore, an appropriate stability test...
Background Postoperative administration of parenteral nutrition has become routine management in patients with gastrointestinal cancer. Providing patient the complete containing not only macronutrients and electrolytes but also adequate doses vitamins is a significant issue nutritional therapy. The aim study was to develop high dose vitamin C (500 mg) evaluate their stability. Methods Five compositions were developed stored for seven days three different conditions. Physical stability...
The administration of total parenteral nutrition (TPN) is a common procedure in intensive care units, where the concomitant use other intravenous medication frequently needed. One particularly dangerous complications for neurosurgical patients meningitis, which high doses ampicillin (AMP) are used. In such cases, addition AMP to TPN admixtures would be desirable procedure. Thus, determination method admixture was developed and validated. An isocratic HPLC analysis performed on LiChrospher...
Ketoprofen (KTF) is often used in hospital wards, especially its intravenous form. According to the literature review, compatibility of ketoprofen with parenteral nutrition (PN) admixtures has not yet been investigated. For this reason, we aimed provide data contributing physical ensure safe co-administration these medications. In study, examined KTF eight selected commercial PN intended for central (Lipoflex Special, Omegaflex Kabiven, SmofKabiven) and peripheral peri, Kabiven Peripheral,...