A5023665013- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Hydrogels: synthesis, properties, applications
- Polysaccharides Composition and Applications
- Polysaccharides and Plant Cell Walls
- Collagen: Extraction and Characterization
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Mesoporous Materials and Catalysis
- Dermatology and Skin Diseases
- biodegradable polymer synthesis and properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bee Products Chemical Analysis
- Electrospun Nanofibers in Biomedical Applications
- Proteins in Food Systems
- Microencapsulation and Drying Processes
- PARP inhibition in cancer therapy
- Protein Interaction Studies and Fluorescence Analysis
- Cannabis and Cannabinoid Research
- 3D Printing in Biomedical Research
- Crystallization and Solubility Studies
Poznan University of Medical Sciences
2015-2025
Semnan University of Medical Sciences
2017
Agomelatine (AGM) is an effective antidepressant with low oral bioavailability due to intensive hepatic metabolism. Transdermal administration of agomelatine may increase its and reduce the doses necessary for therapeutic effects. However, transdermal delivery requires crossing stratum corneum barrier. For this purpose, use microneedles efficiency administration. The aim study was prepare agomelatine-loaded hydrogel suitable coating drug AGM. optimized formulations were subjected...
Mycoses of the skin are infectious diseases caused by fungal microorganisms that generally treated with topical agents. However, such therapy is often ineffective and has to be supported oral use active substances, which, in turn, can cause many side effects. A good alternative for treatment deep-skin mycoses seems microneedles (MNs). The aim this research was fabricate evaluate properties innovative MNs coated a hydrogel as potential carriers clotrimazole (CLO) deep infections. 3D printing...
The aim of this study was to characterize a 1:1 molar ratio pharmacologically relevant co-amorphous atorvastatin-irbesartan (ATR-IRB) system obtained by quench cooling the crystalline ATR/IRB physical mixture for potential use in fixed-dose combination therapy. characterized employing standard differential scanning calorimetry (DSC), Fourier transform-infrared spectroscopy (FT-IR), and intrinsic dissolution rate studies. Quantum mechanical calculations were performed obtain information...
The oral cavity is constantly exposed to contact with an external environment. Pathogens can easily access and colonize it, causing a number of medical conditions that are usually accompanied by inflammation, which in turn require intervention cause the deterioration wellbeing. aim this study was obtain polymer films could be carrier for chlorhexidine, active substance used treatment inflammation cavity, at same time act as dressing application on mucous membrane. Combinations three...
Fungal infections pose a significant global health problem, affecting 20–25% of the population and contributing to over 3.75 million deaths annually. Clotrimazole (CLO) is widely used topical antifungal drug, but its efficacy limited by poor penetration through stratum corneum. Microneedle (MN) systems, composed micron-scale structures arranged on patch, offer promising strategy overcome outermost skin barrier enhance drug into deeper layers. However, optimizing MN design, particularly in...
Background: Glioblastoma (GBM) is the most frequently occurring primary malignant central nervous system tumor, with a poor prognosis and median survival below two years. Administration of combination non-steroidal anti-inflammatory drugs natural compounds that exhibit curative or prophylactic effect in cancer new approach to GBM treatment. This study aimed investigate synergistic antitumor activity etoricoxib (ETO) cannabidiol (CBD) cell line model, develop poly(lactic-co-glycolic acid)...
The aim of this study was to obtain films based on sodium alginate (SA) for disintegration in the oral cavity. were prepared with a solvent-casting method, and meloxicam (MLX) as active ingredient suspended 3% solution. Two different solid-dosage-form additives containing disintegrating agents, i.e., VIVAPUR 112® (MCC; JRS Pharma, Rosenberg, Germany) Prosolve EASYtabs SP® (MIX; Germany), used, four combinations drying time temperature tested. influence used disintegrant properties ODFs...
The aim of the study was preparation and comparison two types orodispersible gel films (ODF) by solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as film formers, Kollidon microcrystalline cellulose disintegrant. Meloxicam (MLX), drug to treat rheumatic diseases for children adults, proposed active pharmaceutical ingredient (API). influence polymer disintegrant on properties ODF investigated. evaluation prepared based appearance...
Purpose Most of the studies concerning gellan have been focused on its application as a food ingredient, however, is often considered candidate for development novel pharmaceutical formulations. Taking into account that ion-sensitive, it can be assumed initial mechanical properties change upon contact with body secretions. Therefore, aim work was to investigate rheological pure high-acyl gum hydrogel (0.4%) and mixtures selected simulated fluids. Methods The investigations were performed...