A5066613885- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
- Electrolyte and hormonal disorders
- Nanoparticle-Based Drug Delivery
- Diet and metabolism studies
- Nausea and vomiting management
- Antibiotics Pharmacokinetics and Efficacy
- Phenothiazines and Benzothiazines Synthesis and Activities
- Impact of Technology on Adolescents
- Malaria Research and Control
- Curcumin's Biomedical Applications
- Tea Polyphenols and Effects
- Metal complexes synthesis and properties
- Hepatitis B Virus Studies
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Safe Handling of Antineoplastic Drugs
- Radiation Effects and Dosimetry
- Microwave-Assisted Synthesis and Applications
- Antibiotic Resistance in Bacteria
- Synthesis and Characterization of Heterocyclic Compounds
- Pediatric Pain Management Techniques
- Tuberculosis Research and Epidemiology
- Social Media in Health Education
Poznan University of Medical Sciences
2017-2024
Nanoformulations are regarded as a promising tool to enable the efficient delivery of active pharmaceutical ingredients target site. One best-known and most studied nanoformulations liposomes-spherical phospholipid bilayered nanocarriers resembling cell membranes. In order assess possible effect mixture polyphenols on both stability formulation its biological activity, two compounds were embedded in liposomes-(i) curcumin (CUR), (ii) peracetylated derivative (-)-epigallocatechin 3-O-gallate...
Glioblastoma (GBM) is the most common malignant neoplasm in adults among all CNS gliomas, with 5-year survival rate being as low 5%. Among nanocarriers, liposomal nanoformulations are considered a promising tool for precise drug delivery. The herein presented study demonstrates possibility of encapsulating four selected natural compounds (curcumin, bisdemethoxycurcumin, acteoside, and orientin) their mixtures cationic nanoformulation composed two lipid types (DOTAP:POPC). In order to...
Patients referred to intensive care units (ICU) require special due their life-threatening condition, diseases and, frequently, malnutrition. Critically ill patients manifest a range of typical physiological changes caused by predominantly catabolic reactions in the body. It is necessary provide with proper nutrition, for example administering total parenteral nutrition (TPN). The addition linezolid TPN mixtures treated linezolid-sensitive infections may reduce extent vascular access...
Epilepsy is defined as a group of concerning problems related to the nervous system; its defining feature predisposition epileptic seizures. The frequency seizures in intensive care units (ICU) ranges from 3.3% 34%, and ICU antiepileptic treatment routine practice. administration drugs through same infusion line not recommended but common clinical practice, especially ICU. Incompatibilities between parenteral nutrition admixtures (PNAs) are medical errors pose risks patient safety....
The growing popularity of health education on social media indicates the need for its appropriate evaluation. This paper aims to present potential Kirkpatrick Model (KM) with New World (NWKM) additions evaluate nutritional provided by dieticians via Instagram. Instagram profiles ten providing their followers were analyzed in March and April 2021. study sample included both macro- micro-influencers. quantitative data Engagement Rate number likes comments per post. qualitative analysis was...
Parenteral nutrition (PN) admixtures are prone to interacting with drugs administered intravenously via a common catheter. This may cause threat patient's health and life. The literature that has been reported on the compatibility of loop diuretics PN presents conflicting results. work aimed study furosemide torsemide used in clinical practice. Undiluted solutions were mixed at various ratios determined by flow rates. In order assess compatibility, visual control was followed pH measurement,...
Chemotherapy-induced nausea and vomiting are defined as the most common of side effects treatment and, at same time, very difficult to accept for patients’, frequently causing changes in therapy regimen, significantly reducing its effectiveness. Thus, an antiemetic prophylactic is essential provision such a patient. Pharmacotherapy often includes various drugs, including antiemetics, with administration drugs by injection through two separate catheters being preferred method. However,...
Vinpocetine (VP) is distributed after oral and intravenous administration, its uptake in the thalamus, basal ganglia, visual cortex. Due to poor bioavailability (~7%) marked first-pass effect (~75%), including a short half-life (2-3 h), administration of VP limited. It requires frequent drug obtain therapeutic effect. Attempts overcome these difficulties include use new delivery systems and/or alternative routes administration. One possibility common lipid emulsion using same catheter....
Intravenous drug incompatibilities are a common cause of medical errors, contributing to ineffective therapy and even life-threatening events. The co-administration drugs must always be supported by studies confirming compatibility thus guarantee the therapy’s safety. Particular attention should paid possible or degradation intravenous cephalosporins in different infusion regimens since administration with inadequate quality may treatment failure. Therefore, an appropriate stability test...
Diclofenac (DC) [2-(2,6-Dichloroanilino)phenyl]acetic acid,) and aceclofenac (AC) 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid in substantia were subjected to ionizing radiation the form of a beam high-energy electrons from an accelerator standard sterilization dose 25 kGy higher doses (50–400 kGy). We characterized non-irradiated irradiated samples DC AC by using following methods: organoleptic analysis (color, form), spectroscopic (IR, NMR, EPR), chromatographic (HPLC),...
Cefquinome sulfate is a veterinary, parenteral, fourth-generation cephalosporin with methoxyimino–aminothiazolyl moiety into the acyl side chain and quaternary quinoline group at position 3 of cefem ring. known to undergo degradation, which could be additionally increased by presence some critical factors such as temperature, relative air humidity, buffer components well hydrogen hydroxide ions. The aim this study was evaluate underlying stability cefquinome (CFQ) in aqueous solution solid...
Tuberculosis (TB) has been present in the history of human civilization since time immemorial and caused more deaths than any other infectious disease. It is still considered one ten most common epidemiologic causes death world. As a transmissible disease, it initiated by rod-shaped (bacillus) mycobacteria. The management tuberculosis became possible owing to several discoveries beginning 1882 with isolation TB bacillus Robert Koch. diagnosis was enabled finding staining method for bacteria...
Furosemide and torasemide (loop diuretics) are used to treat hypertension or pulmonary edema. They often administered in the parenteral route. In critically ill patients, there is a problem of limited number venous accesses, which complicates polytherapy. Drugs unknown compatibility must be separately, increases patients receiving nutrition. Lipid emulsions have been introduced into clinical practice as high-calorie, non-glucose source energy for administration, but they can also lipophilic...
Ondansetron (OND) is a serotonin type 3 receptor antagonist that exhibits antiemetic activity. From the clinical point of view, vomiting and nausea prevention an important task. Anticancer treatment recovery impact patient’s overall state by affecting appetite, well-being, physical activity, consequently, nutrition quality. Depending on indication condition, parenteral administered to meet full nutritional requirements. In addition, drugs can be added (PN) admixture treat chemo- or...
The first-order degradation kinetics of epidoxorubicin were investigated as a function pH, temperature, and buffers concentrations. was followed by HPLC. Buffer catalysis observed in acetate phosphate buffers. pH-rate profiles obtained at 333, 343, 353, 363 K. expression <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Stability evaluation is an integral part of quality studies substances for pharmaceutical use and it conducted to establish whether the therapeutic effectiveness safety a given drug can be guaranteed over entire period its shelf life.Diseases bacterial etiology pose challenge in treatment people animals.A significant limitation involved antibacterial drugs veterinary medicine results from need ensure that particular safe not only animals but also their handlers consumers animal food products...