A5085453358- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Stress Responses and Cortisol
- Ovarian function and disorders
- Telomeres, Telomerase, and Senescence
- Animal Genetics and Reproduction
- Renal and related cancers
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- Sex and Gender in Healthcare
- Neuroendocrine regulation and behavior
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- RNA Research and Splicing
Utah State University
2016-2025
Genomics England
2025
Universidade Federal de Pelotas
2024
Tuskegee University
2023
University of Pennsylvania
2009-2016
University of Bolton
2012
Genomics (United Kingdom)
2012
Massachusetts Eye and Ear Infirmary
2012
Harvard University
2012
Smith-Kettlewell Eye Research Institute
2012
Previously we reported that prepubertally ovariectomized mice received young transplanted ovaries at a postreproductive age showed 40% increase in life expectancy. To study this phenomenon greater detail, 11-month-old and ovary-intact CBA/J underwent ovarian transplantation with 60-day-old or sham surgery. Results from observations on transplant recipients the current extended our previous results. Whereas intact control lived an average of 726 days, 770 days (i.e., 780 for 757 recipients)....
Adeno-associated virus (AAV) vectors are currently being tested not only in small animal models such as mice but also large models, including pigs, dogs, and horses. Natural exposure to AAV occurs most of the species used these studies potentially elicits a neutralizing humoral immune response AAV. In this study, we show prevalence antibodies (NAbs) several serotypes animals measured by an vitro NAb assay ability NAbs block transduction vivo mouse model passive transfer assay. The results...
Changes in placental development have been associated with foetal abnormalities after vitro embryo manipulations. This study was designed to investigate bovine conceptus and substrate levels plasma fluids vivo- vitro-produced (IVP) concepti neonates. In vivo-produced IVP embryos were derived by established production procedures. Pregnant animals from both groups slaughtered on days 90 or 180 of gestation, allowed go term. Conceptus neonatal physical traits recorded; foetal, maternal blood,...
Abstract Cellular senescence is a defense mechanism to arrest proliferation of damaged cells. The number senescent cells increases with age in different tissues and contributes the development age-related diseases. Old mice treated senolytics drugs, dasatinib quercetin (D+Q), have reduced burden. aim this study was evaluate effects D+Q on testicular function fertility male mice. Mice ( n = 9/group) received D (5 mg kg −1 ) Q (50 via gavage every moth for three consecutive days from 3 8...
The period immediately after birth is a vital time for all newborn calves as the cardiovascular, respiratory, and other organ systems adapt to life ex utero. Reported neonatal mortality rates suggest this be especially critical in cloned calves; yet prospective, controlled studies on physiological status of these are lacking. objectives study were compare (birth 48 h age) physical clinical characteristics placental morphology embryo transfer control delivered by cesarean section induced...
Potential applications of somatic cell nuclear transfer to agriculture and medicine are currently constrained by low efficiency high rates embryonic, fetal, neonatal loss. Nuclear in cattle was compared between three donor-cell treatments from a single animal, four sequential stages differentiation lineage genotype, the same type two donors. Cumulus granulosa donor cells resulted greater proportion viable day-7 embryos than ear-skin cells; pregnancy rate losses were not different among...
Although a majority of clones are born normal and apparently healthy, mortality rates nearly 30% described in many reports. Such losses major limitation cloning technology represent substantial economic investment as well justifiable animal health welfare concerns. Prospective, controlled studies needed to understand fully the causes neonatal develop preventive therapeutic strategies minimize losses. We report here findings on hematologic biochemical profiles cloned control calves immediate...
The female cardioprotective advantage, present in mammals of a reproductively competent age, is lost during the transition to postreproductive state. role reproductive hormones this most evident women with premature ovarian failure, where reduced estrogen production has been associated an increased incidence early death from cardiovascular disease. Previously, we reported that postreproductive-aged mice received young ovaries displayed life span. Subsequent histopathological analysis...
Bivalve molluscs are newly discovered models of successful aging. Here, we test the hypothesis that extremely long-lived bivalves not uniquely resistant to oxidative stressors (eg, tert-butyl hydroperoxide, as demonstrated in previous studies) but exhibit a multistress resistance phenotype. We contrasted (in terms organismal mortality) genotoxic stresses (including topoisomerase inhibitors, agents cross-link DNA or impair genomic integrity through alkylation methylation) and mitochondrial...
Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, effectiveness senolytic drugs in reducing damage mice with MASLD is not clear. Additionally, has reported adversely affect male reproductive function. Therefore, this study aimed evaluate protective effect on and fertility MASLD. Three-month-old were fed a standard diet (SD) or choline-deficient western (WD) until 9 months age. At 6 age randomized within dietary...
Acid ceramidase is required to maintain the metabolic balance of several important bioactive lipids, including ceramide, sphingosine and sphingosine-1-phosphate. Here we show that addition recombinant acid (rAC) primary chondrocyte culture media maintained low levels ceramide led elevated by 48 hours. Surprisingly, after three weeks expansion chondrogenic phenotype these cells also was markedly improved, as assessed a combination histochemical staining (Alcian Blue Safranin-O), western...
Previously, transplantation of ovaries from young, cycling mice into old, postreproductive-age increased life span and decreased cardiomyopathy at death. We anticipated that the same factors could also influence progression orthopedic disease. At 11 months age, prepubertally ovariectomized ovary-intact (including reproductively acyclic mice) received new 60-day-old ovaries. death, epiphyseal bone in proximal tibia distal femur mid-shaft tibial femoral diaphyseal was analyzed with...
Abstract The mammalian female is born with a limited ovarian reserve of primordial follicles. These follicles are slowly activated throughout the reproductive lifecycle, thereby determining lifecycle length. Once exhausted, women undergo menopause, which associated several metabolic perturbations and higher mortality risk. Long before exhaustion reserve, females experience severe declines in fertility health. As such, significant efforts have been made to unravel mechanisms that promote...