A5062820625- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Reproductive System and Pregnancy
- Genetics, Aging, and Longevity in Model Organisms
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Acute Myeloid Leukemia Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Ovarian function and disorders
- Reproductive Physiology in Livestock
- Retinoids in leukemia and cellular processes
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Single-cell and spatial transcriptomics
German Cancer Research Center
2022-2024
Heidelberg University
2022-2024
University Hospital Heidelberg
2023
Charité - Universitätsmedizin Berlin
2013-2018
Humboldt-Universität zu Berlin
2017-2018
Freie Universität Berlin
2017
The female reproductive tract (FRT) undergoes extensive remodeling during cycling. This recurrent and how it shapes organ-specific aging remains poorly explored. Using single-cell spatial transcriptomics, we systematically characterized morphological gene expression changes occurring in ovary, oviduct, uterus, cervix, vagina at each phase of the mouse estrous cycle, decidualization, into aging. These analyses reveal that fibroblasts play central-and highly organ-specific-roles FRT by...
Retinoids are vitamin A (retinol) derivatives and complex regulators of adipogenesis by activating specific nuclear receptors, including the retinoic acid receptor (RAR) retinoid X (RXR). Circulating retinol-binding protein 4 (RBP4) its membrane STRA6 coordinate cellular retinol uptake. It is unknown whether levels activity RAR RXR in adipocyte precursors linked via RBP4/STRA6. Here, we show that expressed precursor cells and, dictated apo- holo-RBP4 isoforms, mediates bidirectional...
Reduced de novo lipogenesis in adipose tissue, often observed obese individuals, is thought to contribute insulin resistance. Besides trapping excess glucose and providing for triglycerides energy storage, endogenously synthesized lipids can function as potent signaling molecules. Indeed, several specific their molecular targets that mediate sensitivity have been recently identified. Here, we report carbohydrate-response element-binding protein (ChREBP), a transcriptional inducer of use...
Abstract The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due chronic dietary stimulation contributes the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that oxidoreductase retinol saturase (RetSat) is involved in fatty liver. Hepatic RetSat expression correlates with steatosis serum triglycerides (TGs) humans. Liver-specific depletion obese mice lowers circulating TGs normalizes...
Reduced expression of the INDY (I'm not dead yet) tricarboxylate carrier increased life span in different species by mechanisms akin to caloric restriction. Mammalian homolog (mIndy, SLC13A5) gene seems be regulated hormonal and/or nutritional factors. The underlying are still unknown. current study revealed that mIndy and [14C]-citrate uptake was induced physiological concentrations glucagon via a cAMP-dependent cAMP-responsive element–binding protein (CREB)–dependent mechanism primary rat...
Alexander Tolkachova, Cornelius Fischerb, Thomas H. Ambrosicd, Melissa Bothee, Chung-Ting Hanb*, Matthias Muenznera, Susanne Mathiaf, Marjo Salmineng, Georg Seiferth, Mario Thielei, N. Dudai, Sebastiaan Meijsinge, Sascha Sauerb, Tim J. Schulzcd & Michael Schuppa*a Charité-Universitätsmedizin Berlin, Humboldt-Universität zu and Berlin Institute of Health, Pharmacology, Germanyb Laboratory Functional Genomics, Nutrigenomics Systems Biology, BIMSB BIH Genomics Platforms, Max Delbrück Center for...
Adipose tissue dysfunction is a prime risk factor for the development of metabolic disease. Bone morphogenetic proteins (BMPs) have previously been implicated in adipocyte formation. Here, we investigate role BMP signalling adipose health and systemic glucose homeostasis. We employed Cre/loxP system to generate mouse models with conditional ablation receptor 1A differentiating mature adipocytes, as well tissue-resident myeloid cells. Metabolic variables were assessed by insulin tolerance...
The female reproductive tract (FRT) undergoes extensive remodeling during each cycle, regulated by systemic changes in sex hormones. Whether this recurrent influences a specific organ’s aging trajectory is unknown. To address this, we systematically characterized at single-cell resolution the morphological and transcriptional that occur ovary, oviduct, uterus, cervix, vagina phase of mouse estrus decidualization, into aging. Transcriptional cell-to-cell communication networks cycle are...
Abstract In vitro fertilization has been developed to overcome reduced fertility, which is increasingly due a decline in reproductive cell quality during aging. Here, we quantitatively investigated the interplay between superovulation and aging mouse oocytes their paired granulosa cells using newly adapted isolation techniques. We tested hypothesis that disrupts oocyte maturation, revealing key intercellular communication pathways dysregulated by forced hormonal stimulation. further...