A5100332177- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Reinforcement Learning in Robotics
- Microbial Metabolic Engineering and Bioproduction
- Advanced Control Systems Optimization
- Biofuel production and bioconversion
- Lysosomal Storage Disorders Research
- Studies on Chitinases and Chitosanases
- Immune Response and Inflammation
- Organ Transplantation Techniques and Outcomes
- Model Reduction and Neural Networks
- Traffic and Road Safety
- Bone health and treatments
- Linguistics, Language Diversity, and Identity
- Cardiovascular and Diving-Related Complications
- Cellular transport and secretion
- Luminescence and Fluorescent Materials
- Real-time simulation and control systems
- Vascular anomalies and interventions
- Virus-based gene therapy research
- Nanoparticles: synthesis and applications
- Translation Studies and Practices
- Hydrology and Drought Analysis
- Microplastics and Plastic Pollution
University of Pennsylvania
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Huaiyin Institute of Technology
2022-2023
Tianjin Normal University
2020-2022
East China Normal University
2021
Nankai University
2012
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major types, and provides perspectives for future development. therapeutics
The development of lipid nanoparticle (LNP) formulations for targeting the bone microenvironment holds significant potential nucleic acid therapeutic applications including regeneration, cancer, and hematopoietic stem cell therapies. However, delivery to remains a challenge due several biological barriers, such as low blood flow in bone, blood–bone marrow affinity between drugs minerals, which leads unfavorable dosages microenvironment. Here, we construct series bisphosphonate (BP)...
Inspired by the success of imitation and inverse reinforcement learning in replicating expert behavior through optimal control, we propose a based approach to safe controller synthesis on control barrier functions (CBFs). We consider setting known nonlinear affine dynamical system assume that have access trajectories generated an - practical example such would be kinematic model self-driving vehicle with (e.g., avoid collisions obstacles environment) human driver. then analyze optimization...
The rational design and preparation of available fullerene@metal-organic matrix hybrid materials are profound significance in electrochemical biosensing applications due to their unique photoelectric properties. In this work, C60@UiO-66-NH2 nanocomposites serve as greatly promising modify electrodes fix aptamers, resulting a remarkable aptasensor for impedimetric sensing tobramycin (TOB). Nanoscale composites have preferable electroactivity small particle size with more exposed functional...
Lipid nanoparticles (LNPs) play a crucial role in delivering messenger RNA (mRNA) therapeutics for clinical applications, including COVID-19 mRNA vaccines. While can be chemically modified to become immune-silent and increase protein expression, LNPs still trigger innate immune responses cause inflammation-related adverse effects. Inflammation turn suppress translation reduce the therapeutic effect. Dexamethasone (Dex) is widely used anti-inflammatory corticosteroid medication that...
mRNA therapeutics are promising platforms for protein replacement therapies and gene editing technologies. When delivered via non-viral delivery systems, such as lipid nanoparticles (LNPs), easy to produce show low toxicity immunogenicity. However, LNPs limited efficiency tissue specificity in certain applications. To overcome this, we designed RGD peptide (Arg-Gly-Asp) based ionizable lipids, which can be formulated into integrin binding on cells targeted delivery. RGD-LNPs were using...
Rationale: The transcatheter closure and atrioseptopexy are the main treatment methods for atrial septal defect (ASD). However, persistent hypoxemia due to iatrogenic diversion of inferior vena cava (IVC) left atrium (LA) is reported as a rare complication after ASD closure. Contrast echocardiology reliable powerful tool detect identify etiology accurately. Patient concerns: We 2 patients (a 11-year-old boy [Patient 1] 39-year-old female 2]) with exertional dyspnea robotic atrioseptopexy,...
Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked PD by genome-wide association studies (GWAS) impact on cerebrospinal fluid (CSF) proteins reflecting function. Starting with 525 candidate gene-single nucleotide polymorphism (SNPs) pairs nominated Mendelian randomization from published GWAS, we filtered SNPs downstream evaluation, based strength of and brain gene expression. genotyped top...
A MOF/GO-based electrochemical biosensor is successfully fabricated for monitoring ATP even in various real samples.
Herein, further SAR studies of lead compound NSC746457 (Shen, J.; Woodward, R.; Kedenburg, J. P.; Liu, X. W.; Chen, M.; Fang, L. Y.; Sun; D. X.; Wang. P. G. Med. Chem. 2008, 51, 7417-7427) were performed, including the replacement trans-styryl moiety with a 2-substituted benzo-hetero aromatic ring and introduction substituent onto central methylene carbon. A promising chiral lead, S-(E)-3-(1-(1-(benzo[d]oxazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide (12, NK-HDAC-1),...
The fabricated Au@POF-based biosensor has outstanding detectability toward oxytetracycline even in various real samples.
The GPNMB single-nucleotide polymorphism rs199347 and GBA1 variants both associate with Lewy body disorder (LBD) risk. encodes glycoprotein nonmetastatic melanoma protein B (GPNMB), a biomarker for GBA1-associated Gaucher's disease.
As a green lining open space, greenways are closely related to the life of urban residents.At present, reports crimes occurring in emerging an endless stream.In order explore factors affecting greenway safety, this study, under guidance CPTED theory, conducts research by means big geodata.Three representative Beijing area-the Northwest Tucheng greenway, Second Ring Road and Three Mountains Five Gardens greenway-are taken as objects.Through utilization geodata information from each platform,...