A5100320325- Thyroid Cancer Diagnosis and Treatment
- Higher Education and Teaching Methods
- Traditional Chinese Medicine Studies
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Parkinson's Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Ovarian function and disorders
- Bone and Joint Diseases
- Patient-Provider Communication in Healthcare
- Neuroendocrine Tumor Research Advances
- Law, logistics, and international trade
- Gastric Cancer Management and Outcomes
- Neurological disorders and treatments
- Asian American and Pacific Histories
- Lipid metabolism and disorders
- Advanced Decision-Making Techniques
- Medical Research and Treatments
- Regional Economic and Spatial Analysis
- Head and Neck Anomalies
- Down syndrome and intellectual disability research
- AI in cancer detection
- Advanced MRI Techniques and Applications
- Reproductive Biology and Fertility
- Autophagy in Disease and Therapy
Sichuan University
2021-2025
National Health and Family Planning Commission
2022-2025
Kunming Medical University
2017-2025
First Affiliated Hospital of Kunming Medical University
2017-2025
Xi'an Jiaotong University
2025
University of Iowa
2020-2025
University of North Carolina at Chapel Hill
2023-2024
Qilu Hospital of Shandong University
2024
Soochow University
2023-2024
First Affiliated Hospital of Soochow University
2023-2024
Abstract Mitochondrial dysfunction contributes to the development of secondary brain injury (SBI) following intracerebral hemorrhage (ICH) and represents a promising therapeutic target. Celastrol, primary active component Tripterygium wilfordii , is natural product that exhibits mitochondrial neuronal protection in various cell types. This study aims investigate neuroprotective effects celastrol against ICH‐induced SBI explore its underlying mechanisms. Celastrol improves neurobehavioral...
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated fatty acids (SFAs) in cells induces cellular lipotoxic damage increases risk wide spectrum metabolic diseases including type 2 diabetes (T2D) nonalcoholic liver disease (NAFLD). Monounsaturated (MUFAs) polyunsaturated (PUFAs) have been reported to combat SFA-induced damage. However, comparative studies two types unsaturated (UFAs) are still limited. We investigated effects different MUFAs PUFAs human...
Abstract Background Current methods utilizing preoperative magnetic resonance imaging (MRI)‐based radiomics for assessing lymphovascular invasion (LVI) in patients with early‐stage breast cancer lack precision, limiting the options surgical planning. Purpose This study aimed to develop a sophisticated deep learning framework called “Prior Clinico‐Radiological Features Informed Multi‐Modal MR Images Convolutional Neural Network (PCMM‐Net)” improve accuracy of LVI prediction cancer. By...
ABSTRACT Objectives Metabolic dysfunction‐associated steatohepatitis (MASH) is a significant risk factor for cirrhosis and hepatocellular carcinoma, which there currently no effective treatment. This study aimed to investigate the regulatory mechanism between endoplasmic reticulum stress (ER stress) pyroptosis in liver under context of MASH. Methods Results Pyroptosis was examined both vivo vitro ER models. The expression levels nucleotide‐binding oligomerisation domain‐like receptor protein...
Abstract Objective Active surveillance (AS) offers a viable alternative to surgical intervention for the management of indolent papillary thyroid carcinoma (PTC), helping minimize incidence unnecessary treatment. However, broader adoption AS is hindered by need more reliable diagnostic markers. This study aimed identify differences between and progressive PTC find new targets biomarker development therapeutic strategies. Methods We used single-cell RNA sequencing (scRNA-seq) analyze cellular...
Due to the lack of an accurate preoperative diagnostic method central lymph node metastasis (CLNM) papillary thyroid cancer (PTC), prophylaxis dissection remains controversial. The present study investigated clinicopathological features PTC patients and risk factors CLNM. with respect sex, age, initial symptoms, observation, tumor diameter, multifocality, extrathyroidal invasion, pathological data combined other diseases, were analyzed retrospectively. CLNM by Chi-squared test multivariate...
Side effects are an unavoidable consequence of chemotherapy drugs, during which liver injury often takes place. The current study was designed to investigate the protective effect Astragalus polysaccharides (APS) against hepatotoxicity induced by frequently-used chemical therapy agents, cyclophosphamide (CTX), docetaxel (DTX) and epirubicin (EPI)) in mice. Mice were divided into five groups, controls, low or high dose groups (DTXL, CTXL, EPIL DTXH, CTXH, EPIH), chemotherapeutics+APS...
Down syndrome (DS) is the most common genetic cause of Alzheimer's disease (AD), but diagnosis AD in DS challenging due to intellectual disability which accompanies DS. When disease-modifying agents for are approved, reliable biomarkers will be required identify when and how long people with should undergo treatment. Three cardinal neuropathological features characterize AD, DS-Aβ amyloid plaques, tau neurofibrillary tangles, neuronal loss. Here, we quantified plasma all 3 a large cohort...
The aging global population has led to an increased burden of cognitive impairment in older adults.
Variations in the prevalence of metabolic syndrome (MetS) among women with polycystic ovary (PCOS) different races were reported. We sought to report this and its components Chinese PCOS compared these characteristics healthy controls.Anthropometric measurements biochemical parameters evaluated 578 patients diagnosed by Rotterdam criteria 281 age- body mass index (BMI)-matched controls. International Diabetes Federation for MetS used.The was 16.8% study, 60.7% displayed at least one...
Pain in masticatory muscles is among the most prominent symptoms of temperomandibular disorders (TMDs) that have diverse and complex etiology. A common complaint TMD unilateral pain craniofacial muscle can cause a widespread bilateral sensation, although underlying mechanism remains unknown. To investigate whether inflammation masseter allodynia, we generated induced by injection complete Freund's adjuvant (CFA) rats, measured head withdrawal threshold at different time points using von Frey...
Early preoperative diagnosis of central lymph node metastasis (CNM) is crucial to improve survival rates among patients with papillary thyroid carcinoma (PTC). Here, we analyzed clinical data from 2862 PTC and developed a scoring system using multivariable logistic regression testified by the validation group. The predictive diagnostic effectiveness was evaluated based on consistency, discrimination ability, accuracy. considered seven variables: gender, age, tumor size, microcalcification,...
Objective The purpose of this study was to evaluate the safety, efficiency, and cost expenditure remote programming in patients with Parkinson's disease (PD) after deep brain stimulation (DBS). Methods A total 74 who underwent DBS at Department Neurosurgery, Zhongnan Hospital Wuhan University between June 2018 2020 were enrolled study. There 27 group 47 outpatient group. Clinical data, adverse events, expenditure, satisfaction compared two groups. Results 36 times performed on group, four...
Chronic low-grade inflammation plays an important role in the pathogenesis of type 2 diabetes. Src homology domain-containing tyrosine phosphatase-2 (SHP2) has been reported to play diverse roles different tissues during development metabolic disorders. We previously that SHP2 inhibition macrophages results increased cytokine production. Here, we investigated association between and diseases. Unexpectedly, found mice with a conditional knockout (cSHP2-KO) have ameliorated cSHP2-KO fed...
<b><i>Objective:</i></b> Parkinson’s disease (PD) is a profoundly incapacitating neurodegenerative disorder, which presents substantial challenge to the economic sustainability of global healthcare system. The present study seeks clarify factors that contribute costs associated with PD hospitalization and analyze burden it imposes. <b><i>Methods:</i></b> We examined data 19,719 patients primary diagnosis who were admitted hospitals in Hubei...
Abstract Dark green vegetables include dark leafy and broccoli. They are sources of many essential nutrients, including vitamins A, B C, folate, fibre, carotenoids flavonoids. This study aimed to explore the association between dietary vegetable intake cognitive function in US older adults. We included 2344 adults (≥60 years old) from National Health Nutrition Examination Survey ( NHANES ) 2011–2014 cycles. consumption was assessed using a continuous variable (cups/day) two categorical...
Background: Different techniques of video-assisted thoracoscopic sympathetic surgery have become the radical treatments for palmar and axillary hyperhidrosis (AH). However, there is no consensus over which technique can make a minimal incidence compensatory (CH). This study was designed to compare CH after different at same levels in treatment upper limb facial (FH). Methods: The databases PubMed, Web Science, ScienceDirect, Ovid Medline, Embase, Cochrane Library were searched identify...
Book Review| April 01 2019 Discriminating Sex: White Leisure and the Making of American “Oriental” “Oriental”. By Amy Sueyoshi. Urbana: University Illinois Press, 2018. 212 pp. Notes index. $99 (cloth); $26 (paper). Wen Liu at Albany, State New York is Assistant Professor Women’s, Gender, Sexuality Studies York. focuses her research on engagement between global social movements psychological theories racial, gender, sexual subjectivities, particularly intersection LGBTQ diasporic Asian...