A5008978237- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Erythrocyte Function and Pathophysiology
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Gout, Hyperuricemia, Uric Acid
- Adipose Tissue and Metabolism
- Curcumin's Biomedical Applications
- Cannabis and Cannabinoid Research
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
Sichuan University
2020-2025
National Health and Family Planning Commission
2020-2025
West China Hospital of Sichuan University
2022-2024
Pyroptosis is a novel programmed cell death. It identified as caspase-1 dependent and characterized by plasma-membrane rupture release of proinflammatory intracellular contents inculuding IL-1 beta IL-18. distinct from other forms death, especially apoptosis that nuclear cytoplasmic condensation elicited via activation caspase cascade. In pyroptosis, gasdermin D (GSDMD) acts major executor, while NLRP3 related inflammasome closely linked to activation. Given pyroptosis has played critical...
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated fatty acids (SFAs) in cells induces cellular lipotoxic damage increases risk wide spectrum metabolic diseases including type 2 diabetes (T2D) nonalcoholic liver disease (NAFLD). Monounsaturated (MUFAs) polyunsaturated (PUFAs) have been reported to combat SFA-induced damage. However, comparative studies two types unsaturated (UFAs) are still limited. We investigated effects different MUFAs PUFAs human...
Background Monounsaturated fatty acids (MUFAs) and polyunsaturated (PUFAs) have been reported to combat saturated acid (SFA)-induced cellular damage, however, their clinical effects on patients with metabolic diseases such as diabetes hyperlipidemia are still controversial. Since comparative studies of the these two types unsaturated (UFAs) limited. In this study, we aimed compare protective various UFAs pancreatic islets under stress SFA-induced disorder lipotoxicity. Methods Rat insulinoma...
ABSTRACT Objectives Metabolic dysfunction‐associated steatohepatitis (MASH) is a significant risk factor for cirrhosis and hepatocellular carcinoma, which there currently no effective treatment. This study aimed to investigate the regulatory mechanism between endoplasmic reticulum stress (ER stress) pyroptosis in liver under context of MASH. Methods Results Pyroptosis was examined both vivo vitro ER models. The expression levels nucleotide‐binding oligomerisation domain‐like receptor protein...
Nonalcoholic fatty liver disease (NAFLD), characterized by hepatic lipid deposition, is one of the most prevalent chronic metabolic disorders globally, and its pharmaceutical treatments are still limited. Excessive accumulation triggers endoplasmic reticulum (ER) stress autophagy flux dysfunction, which important mechanisms for NAFLD. Trehalose (Tre), a natural disaccharide, has been identified to reduce steatosis glucose intolerance. However, underlying NAFLD remain unclear. In this study,...
<title>Abstract</title> The full text of this preprint has been withdrawn by the authors while they make corrections to work. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.
Abstract Necroptosis and pyroptosis are lytic inflammatory types of programmed cell death that require the membrane destruction predominantly driven by mixed lineage kinase domain-like (MLKL) gasdermin D (GSDMD) proteins, respectively. However, crosstalk between them remains largely unknown. Here, our research discloses endoplasmic reticulumn transmembrane protein inositol-requiring enzyme-1α (IRE-1α) is a potential modulator both necroptosis pyroptosis, paricularly in liver pathology....
<title>Abstract</title> Necroptosis and pyroptosis are lytic inflammatory types of programmed cell death that require the membrane destruction predominantly driven by mixed lineage kinase domain-like (MLKL) gasdermin D (GSDMD), respectively. However, crosstalk between them remains largely unknown. Here, we disclose inositol-requiring enzyme-1α (IRE-1α) is a potential modulator both necroptosis pyroptosis, particularly in liver pathology. In vivo, found pharmacological suppression IRE-1α...