A5088659658- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Computational Drug Discovery Methods
- Amyotrophic Lateral Sclerosis Research
University of Sheffield
2020-2024
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk developing late-onset Alzheimer's Disease (AD), but the mechanism underlying this link is poorly understood. In particular, relevance direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all associate with Aβ in early stages aggregation then fall away as fibrillation happens. ApoE-Aβ co-aggregates account for ~50% mass diffusible aggregates detected frontal...
Hypoxia is a feature of neurodegenerative diseases, and can both directly indirectly impact on neuronal function through modulation glial function. Astrocytes play key role in regulating homeostasis within the central nervous system, mediate hypoxia-induced changes response to reduced oxygen availability. The current study performed detailed characterization transcriptomic profile astrocytes vitro. Human were cultured under normoxic (5% CO2, 95% air) or hypoxic conditions (1% O2, 5% 94% N2)...
<title>Abstract</title> Which isoforms of apolipoprotein E (apoE) we inherit determine our risk developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, relevance direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all associate with Aβ in early stages aggregation then fall away as fibrillation happens. ApoE-Aβ co-aggregates account for ~ 50% mass soluble...
Abstract Which isoforms of apolipoprotein E (apoE) we inherit determine our risk developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, relevance direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all associate with Aβ in early stages aggregation then fall away as fibrillation happens. ApoE-Aβ co-aggregates account for ∼50% mass soluble aggregates detected...