A5042592544- Sirtuins and Resveratrol in Medicine
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
- Beetle Biology and Toxicology Studies
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and disorders
- Cytokine Signaling Pathways and Interactions
Nankai University
2021-2024
Tianjin University of Traditional Chinese Medicine
2021
Radiation enteritis (RE) is the most common radiotherapy complication, and effective RE treatments are lacking. Resveratrol exerts beneficial effects on radiation injury. However, effect of resveratrol in radiation-induced intestinal injury underlying mechanism remain unclear. Here, a C57BL/6 mouse model was established an epithelial cell line used to evaluate protective against mechanisms. improved oxidative stress apoptosis via upregulating antioxidant enzymes downregulating p53...
Norcantharidin (NCTD), a cantharidin derivative, induces ROS generation and is widely used to treat CRC. In this study, we clarified the role mechanism of action norcantharidin in increasing CRC sensitivity radiotherapy. We treated cell lines LoVo DLD-1 with NCTD (10 or 50 μmol/L), ionizing radiation (IR, 6 Gy), combination two found that significantly inhibited proliferation cells enhanced their induced by decreasing mitochondrial membrane potential, permeability, promoting cytochrome C...
Intrinsic autophagy is important for the maintenance of intestinal homeostasis and regeneration. Ionizing radiation suppresses intrinsic reduces damage-induced regeneration in intestine, resulting injury. Resveratrol, a sirtuin 1 (SIRT1) agonist, promotes exerts radioprotective effect. In this study, protective effect resveratrol against radiation-induced injury its potential mechanism were investigated. Intestinal epithelial cells (IEC-6) exposed to 10 Gy ionizing (0.1-40.0 μM). Cell...
Radiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance crucial cause poor therapeutic outcomes in cancer. However, underlying mechanism radioresistance still poorly defined. Herein we established a radioresistant cell line and performed transcriptomics analyses to search genes that contribute investigate its association prognosis CRC patients.The was developed from parental HCT116 by stepwise increased dose irradiation....
Abstract Background Local recurrence after surgery and radiochemotherapy seriously affects the prognosis of locally advanced rectal cancer (LARC) patients. Studies on molecular markers related to sensitivity cancers have been widely carried out, which might provide valued information for clinicians carry out individual treatment. Aim To find potential biomarkers tumors predicting postoperative recurrence. Methods In this study, LARC patients undergoing concurrent were enrolled. We focused...
Abstract Background Local recurrence after surgery and radiochemotherapy seriously affects the prognosis of locally advanced rectal cancer (LARC) patients. Studies on molecular markers related to sensitivity cancers have been widely carried out, which might provide valued information for clinicians carry out individual treatment. Aim To find potential biomarkers tumors predicting postoperative recurrence. Methods In this study, LARC patients undergoing concurrent were enrolled. We focused...