A5103240857- Plant and animal studies
- Biological and pharmacological studies of plants
- Traditional Chinese Medicine Studies
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Healthcare and Venom Research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Acupuncture Treatment Research Studies
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- Gallbladder and Bile Duct Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Medicinal Plant Pharmacodynamics Research
- Adipose Tissue and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Transportation Safety and Impact Analysis
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Genetic diversity and population structure
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Treatments and Mutations
Dalian Medical University
2022-2025
First Affiliated Hospital of Dalian Medical University
2022-2025
Soochow University
2014-2024
Second Affiliated Hospital of Soochow University
2014-2024
Guangzhou Medical University
2021
Third Affiliated Hospital of Guangzhou Medical University
2021
Shanxi Province Hospital of Traditional Chinese Medicine
2013-2021
Guangdong Medical College
2019
Shanxi University of Traditional Chinese Medicine
2009-2013
Nanjing Normal University
2008-2012
Circular RNAs (circRNAs) play an important role in the tumorigenesis of pancreatic cancer. However, expression profiles and roles circRNAs cancer remain largely unknown.To identify differentially expressed (DEcircRNAs) between matched normal tissues, bioinformatics analysis was performed. Hsa_circ_0000069 identified by 0.bioinformatics analysis. In addition, level hsa_circ_0000069 tissues cell lines, cell-derived exosomes were assessed using RT-qPCR assay.The markedly upregulated lines....
Doxorubicin (DOX) is a potent anticancer drug; however, it associated with significant cardiotoxicity. CDC20 an E3 ubiquitin ligase that plays role in cell cycle progression and apoptosis various types of cancers. The involvement DOX-induced cardiotoxicity (DIC) poorly understood. Hence, this study aimed to explore the potential development DIC assess whether influences antitumor effects DOX. H9C2 cells were treated DOX, followed by transcriptomic analysis identify differentially expressed...
Abstract Atrial fibrillation is the most common arrhythmia in clinical practice and increases potential risk of stroke, thromboembolism, death. glutathione-S-transferases pi 1 (GSTP1), a key factor ferroptosis, can participate stress signal cell damage pathway through its non-catalytic activity, has role regulating protecting cells from carcinogens electrophilic compounds. However, mechanism GSTP1 angiotensin II-induced atrial have not been studied. We constructed mouse model using Ang II...
DNA‑damage regulated autophagy modulator 1 (DRAM1) is known as a target of TP53‑mediated autophagy, and has been reported to promote the migration invasion abilities glioblastoma stem cells. However, precise contribution DRAM1 cancer cell migration, underlying mechanisms remain unclear. In present study, small interfering (si)RNA or short hairpin RNA mediated knockdown was performed in hepatoblastoma cells were detected vitro vivo. To investigate mechanisms, western blotting...
Abstract Background Prostate cancer (PCa) is one of the most common malignancies in men. YTHDF1 may play an important role promoting PCa progression, but there no reports to date on function PCa. Objective This study explored whether could regulate TRIM44 cells. Methods By querying TCGA database, we evaluated expression PCa, OS and DFS YTHDF1, correlation between We constructed vectors interfere with overexpress examine Differentially expressed mRNAs were identified by mRNA sequencing. The...
Abstract The nuclear receptor-binding SET domain 3 (NSD3) catalyzes methylation of histone H3 at lysine 36 (H3K36), and promotes malignant transformation progression human cancer. Its expression, potential functions underlying mechanisms in pancreatic cancer are studied. Bioinformatics studies results from local tissues show that NSD3 is upregulated tissues, which correlated with poor overall survival. In primary established cells, silencing (by shRNAs) or CRISPR/Cas9-induced knockout...
Myocardial hypertrophy is a chronic cardiac condition that often occurs from long-term pressure or volumetric load on the heart. Propranolol hydrochloride has been employed in research hypertension, pheochromocytoma, myocardial infarction, arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. Current treatments for this have side effects, such as arrhythmias cell death, thus necessitating safer more effective alternatives. Recently, natural products gained attention drug development...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high mortality worldwide. Accumulating researches have indicated that long non‑coding RNAs (lncRNAs) are involved in varies human cancers, including HCC. Nevertheless, specific molecular mechanism lncRNA lysyl oxidase like 1 antisense RNA (LOXL1-AS1) HCC still unclear. Methods LOXL1-AS1 expression was tested via qRT-PCR cells. Functional and assays were respectively done to evaluate biological...
Doxorubicin (DOX) leads to myocardial cell damage and irreversible heart failure, which limits the clinical application of DOX. Naringin has biological functions inhibiting inflammation, oxidative stress apoptosis. Our aim was investigate whether could prevent DOX-related cardiotoxicity in mice. administered by gavage mice were intraperitoneally injected with doxorubicin (1 mg/kg/day) for 15 days. H&E, Masson, TUNEL others experiments examined. NRVMs H9C2 cells treated DOX vitro. Using IF,...
As a widely used medicinal plant, Dendrobium loddigesii Rolfe is always possible target for fraudulent labeling. The identification of D. generally difficult from its morphological and chemical appearance only. In order to develop convenient efficient method loddigesii, six pairs diagnostic ARMS primers were designed based on nrDNA ITS sequences eleven adulterants. results showed that one primer pair (FJB-04-forward, FJB-04-reverse) could be authenticate by generating fragment 353 bp at...
The heart undergoes pathological cardiac hypertrophy as an adaptive response to prolonged stimulation, leading cardiomyocyte hypertrophy, fibroblast proliferation, and increase in extracellular matrix. Chinese medicine monomers are now receiving much attention for the treatment of myocardial remodeling. Biochanin A (BCA) is a kind flavonoid structural monomer, which has certain therapeutic effect on bone thinning disease, aging syndrome, lung cancer, etc. Moreover, it exhibits hypoglycemic,...
Intestinal microbiota plays an important role in the occurrence and treatment of depression. This study investigated whether Wenyang Jieyu decoction (WYJYD) alleviates depressive behavior rat model via regulation intestinal microbiota. Rat depression was established by stress stimulus. SD male rats were randomly allocated into normal control, model, + low-dose WYJYD (1.89 g/kg/d), medium-dose (3.08 high-dose (7.56 fluoxetine (3.33 mg/kg/d) groups. Behavioral changes observed using forced...
Colorectal carcinoma (CRC) is one of the most common cancers, and associated with a poor clinical outcome. The key genes potential prognostic markers in colorectal remain to be identified explored for application. DNA expression/methylation profiles were downloaded from Gene Expression Omnibus (GEO) database identify differentially expressed/methylated (DEGs DEMs). A total 255 372 as being up-regulated down-regulated, respectively, GSE113513, GSE81558, GSE89076. There 3350 hypermethylated...
Clinical study of modified Ganmai Dazao decoction in the treatment yang deficiency climacteric depression and observe effects on neuroendocrine system patients with depression. 86 cases were randomly divided into group treated control Deanxit. The curative effect was evaluated Hamilton's depressive scale (HAMD) pittsburgh sleep quality (PSQI) before at end two four weeks treatment, serum levels serotonin (5-HT), norepinephrine (NE), estradiol (E2), follicle stimulating hormone (FSH),...
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Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors with poor prognosis and inadequate response to treatment, such as gemcitabine (Gem), first-line chemotherapeutic drug. Understanding molecular determinants that control drug resistance Gem critical predict potentially responsive patients improve benefits therapy. Emerging evidence suggests certain developmental pathways, Hippo signaling, are aberrated play important roles in cancers. Although signaling has been...