A5103149190- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Chemokine receptors and signaling
- Coenzyme Q10 studies and effects
- Cardiac Imaging and Diagnostics
- Metabolism, Diabetes, and Cancer
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Radiation Effects in Electronics
Dalian Medical University
2015-2025
First Affiliated Hospital of Dalian Medical University
2015-2025
Washington University in St. Louis
2025
Zero to Three
2017
Chemokine-mediated monocyte infiltration into the damaged heart represents an initial step in inflammation during cardiac remodelling. Our recent study demonstrates a central role for chemokine receptor CXCR2 recruitment and hypertension; however, of CXCL1 its angiotensin II (Ang II)-induced remodelling remain unknown.Angiotensin (1000 ng kg-1 min-1) was administrated to wild-type (WT) mice treated with neutralizing antibody or inhibitor SB265610, knockout (CXCR2 KO) bone marrow (BM)...
Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have shed great light on cardiac regenerative medicine and specifically myocardial repair in heart failure patients. However, the treatment efficacy survival of iPSC-CMs vivo after transplantation yielded inconsistent results.The objective this study was to evaluate ability human improve function a rat postinfarction model.Eight-week-old male Sprague-Dawley rats were randomly selected receive an intramyocardial injection...
Background The association between dyslipidemia, a major risk factor for cardiovascular diseases, and atrial fibrillation (AF) is not clear because of limited evidence. Hypothesis. Dyslipidemia may be associated with increased AF in Chinese population. Methods A total 88 785 participants free from at baseline (2006–2007) were identified the Kailuan Study. Fasting levels cholesterol (TC), low‐density lipoprotein (LDL‐C), high‐density (HDL‐C), triglycerides (TG) measured using standard...
Carboxyl terminus of Hsp70-interacting protein (CHIP) is a critical ubiquitin ligase/cochaperone to reduce cardiac oxidative stress, inflammation, cardiomyocyte apoptosis and autophage etc. However, it unclear whether overexpression CHIP in the heart would exert protective effects against DOX-induced cardiomyopathy. Cardiac-specific transgenic (CHIP-TG) mice wild-type (WT) littermates were treated with DOX or saline. atrophy, dysfunction, stress significantly attenuated CHIP-TG mice. also...
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role more prevalent failure syndromes remains mechanistically unexamined. We observed mis-localization desmin sarcomeric proteins to human myocardium with ischemic mouse hearts post-myocardial infarction ventricular remodeling, mimicking findings autosomal-dominant induced by R120G mutation the cognate chaperone protein, CRYAB. In both syndromes, we demonstrate...
Doxorubicin (DOX) is a potent anticancer drug; however, it associated with significant cardiotoxicity. CDC20 an E3 ubiquitin ligase that plays role in cell cycle progression and apoptosis various types of cancers. The involvement DOX-induced cardiotoxicity (DIC) poorly understood. Hence, this study aimed to explore the potential development DIC assess whether influences antitumor effects DOX. H9C2 cells were treated DOX, followed by transcriptomic analysis identify differentially expressed...
This prospective study included 68,759 Chinese male adults from Kailuan cohort of China who had a standardized medical examination between 2006 and 2007 were followed up for approximately 8 years until occurrence ASCVD, cancer or death December 31, 2014. Subjects divided into four categories based on the quartiles TC, LDL‐C non‐HDL‐C. Cox regression models used to estimate hazard ratios (HRs) their 95% confidence intervals (CIs). During follow‐up, 2,916 males developed ASCVD 1,884 cancer....
The relationship between cumulative non-high-density lipoprotein cholesterol (non-HDL-C) burden and atherosclerotic cardiovascular disease (ASCVD) remains unclear.To prospectively examine the association non-HDL-C ASCVD risk in Kailuan cohort of China.A total 49,679 subjects who were free participated three consecutive examinations 2006, 2008 2010 enrolled. Duration concentration exposure to (cumNon-HDL-C) respectively used estimate extent burden. participants divided into four groups...
Aims: Catheter ablation should be considered in patients with atrial fibrillation (AF) and heart failure (HF) reduced ejection fraction (EF; HFrEF) to improve survival reduce hospitalization. Careful patient selection for AF is key achieving similar outcome benefits. However, limited data exist regarding predictors of recovered fraction. We aimed evaluate the consecutive HF undergoing ablation. Methods Results: A total 156 [67.3% men, median age 63 (11)] underwent initial catheter between...
Abstract We aimed to determine whether hs-CRP is a predictor of future premature ventricular contraction (PVC) events in community based population. A total 101,510 participants were recruited at baseline (2006–2007). The follow-up visits conducted every two years. Participants who free from PVC and achieved the fourth visit, or diagnosed during subsequent included for analyses. Diagnosis was on standard supine resting, 10-s 12-lead ECG. Cox regression applied evaluate association between...
This study aimed to explore the outcomes of His-Purkinje conduction system pacing (HPCSP) and screen predictors left ventricular (LV) complete reverse remodeling in patients with true bundle branch block (LBBB) heart failure reduced ejection fraction (HFrEF).Patients who underwent HPCSP for LBBB HFrEF from April 2018 August 2020 were consecutively enrolled. All participants followed up at least 1 year. Thrombosis, infection, lead dislodgement, perforation, other complications observed after...
Atrial fibrillation (AF) is an established risk factor of left atrial thrombosis and systemic embolism. Traditionally pulmonary embolism (PE) a recognized complication deep vein (DVT). However, whether AF responsible for right leads to PE has not been examined.We retrospectively analyzed medical records patients with confirmed diagnosis (study group) from 2002-2015. Patients without AF, matched by age sex, served as controls (control group). The CHA2DS2-VASc CHADS2 scores were classified...
Abstract Background Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiac myocytes, mutations PQC pathway proteins, such as CRYAB (arginine to glycine at position 120, R120G) BAG3 (proline lysine 209, P209L) induce protein aggregate pathology with cardiomyopathy humans. Novel observations yeast mammalian cells demonstrate mitochondrial uptake of cytosolic aggregates. We hypothesized that aggregates their removal by mitophagy, a lysosomal...
Data presented in this article are supplementary analyzed tables and individual raw data to our research entitled "Short long-term changes platelet inflammatory biomarkers after cryoballoon radiofrequency ablation (Bin Waleed K et al., 2019) [1]". These included activation [P-selectin (CD62P), CD40 ligand (CD40L), factor-4 (PF-4), mean volume (MPV), platelet-leukocyte ratio (P-LCR), distribution width (PDW)]; [high sensitivity CRP (hs-CRP) interleukin-6 (IL-6)] (CB) (RF) ablation. The...
This study aims to evaluate the incidence of ischemic stroke or transient attack (TIA) based on CHA2DS2-VASc scores in non-AF Chinese patients with sinus rhythm.We used health check-up data 101,510 participants from Kailuan Cohort Study. Participants' risk levels were defined by their (range 0-3): Men 0, 1, ≥ 2 and women 2, 3 considered at low, intermediate, high risk, respectively. Cox proportional hazards model was assess association between CHA2DS2-VASc-determined stroke/TIA.The mean 7.5...