A5010211770- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Guidance and Control Systems
- Adaptive Control of Nonlinear Systems
- Venous Thromboembolism Diagnosis and Management
- Advanced Control Systems Optimization
- Cardiovascular Syncope and Autonomic Disorders
- Stability and Control of Uncertain Systems
- Mitochondrial Function and Pathology
- Neural Networks Stability and Synchronization
- Genetics and Neurodevelopmental Disorders
- Metabolomics and Mass Spectrometry Studies
- Fault Detection and Control Systems
- Cardiovascular Effects of Exercise
- Neurological disorders and treatments
- Genomics and Rare Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Gout, Hyperuricemia, Uric Acid
- Glycogen Storage Diseases and Myoclonus
- Machine Learning in Healthcare
- Epilepsy research and treatment
- Control Systems and Identification
University of Massachusetts Chan Medical School
2025
Southern University of Science and Technology
2025
Dalian Medical University
2015-2024
First Affiliated Hospital of Dalian Medical University
2013-2024
Sichuan University
2021-2023
Xiangya Hospital Central South University
2017-2022
Central South University
2017-2022
West China Hospital of Sichuan University
2021
Huazhong University of Science and Technology
2012-2019
Dimensional Imaging (United Kingdom)
2019
Electronic health records (EHRs) contain patient diagnostic records, physician and of hospital departments. For heart failure, we can obtain mass unstructured data from EHR time series. By analyzing mining these time-based EHRs, identify the links between events ultimately predict when a will be diagnosed. However, it is difficult to use existing directly, because they are sparse non-standardized. Thus, this paper proposes an effective robust architecture for failure prediction. The main...
Background The locus for familial cortical myoclonic tremor with epilepsy (FCMTE) has long been mapped to 8q24 in linkage studies, but the causative mutations remain unclear. Recently, expansions of intronic TTTCA and TTTTA repeat motifs within SAMD12 were found be involved pathogenesis FCMTE Japanese pedigrees. We aim identify Chinese Methods performed genetic analysis by microsatellite markers a five-generation pedigree 55 members. also used array-comparative genomic hybridisation (CGH)...
In this study, event-triggered guaranteed cost control problem for discrete-time networked systems (NCSs) with parameter uncertainties and time-varying transmission delays is studied. First, an event-triggering scheme NCSs proposed. Then by using a delay system approach, unified model of state established. By applying Laypunov functional method together linear matrix inequality (LMI) technique, sufficient conditions the existence admissible controller are established, which ensure specific...
Paroxysmal kinesigenic dyskinesia (PKD) is a heterogeneous movement disorder characterized by recurrent attacks triggered sudden movement. PRRT2 has been identified as the first causative gene of PKD. However, it only responsible for approximately half affected individuals, indicating that other loci are most likely involved in etiology this disorder. To explore underlying PRRT2-negative PKD, we used combination strategy including linkage analysis, whole-exome sequencing and copy number...
Abstract Energy restriction (ER) protects against cerebral ischemic injury, but the underlying mechanism remains largely unclear. Here, rats were fed ad libitum (AL) or on an alternate-day food deprivation intermittent fasting (IF) diet for 3 months, followed by middle artery occlusion (MCAO) surgery. The body weight, infarct volume, and neurological deficit score accessed at designated time points. ELISA, qRT-PCR, Western blotting used to determine cytokine secretion expression of SIRT6,...
Mitochondria control cellular metabolism, serve as hubs for signaling and organelle communication, are important the health survival of cells. VPS13D encodes a cytoplasmic lipid transfer protein that regulates mitochondrial morphology, mitochondria endoplasmic reticulum (ER) contact, quality mitochondria. mutations have been reported in patients displaying ataxic spastic gait disorders with variable age onset. Here we used CRISPR/Cas9 gene editing to create related-spinocerebellar ataxia-4...
Abstract Mitochondria control cellular metabolism, serve as hubs for signaling and organelle communication, are important the health survival of cells. VPS13D encodes a cytoplasmic lipid transfer protein that regulates mitochondrial morphology, mitochondria endoplasmic reticulum (ER) contact, quality mitochondria. mutations have been reported in patients displaying ataxic spastic gait disorders with variable age onset. Here we used CRISPR/Cas9 gene editing to create related-spinocerebellar...
Objectives To investigate the effects of gender on association serum uric acid (SUA) levels and atrial fibrillation (AF) prevalence in a community-based Chinese population. Setting Data were obtained from annual Jidong Oilfield employee family member health checkups. The community is geographically located Tangshan City northern China. Participants A total 9078 residents invited to take part survey provided informed consents. Individuals without data ECG or SUA excluded, leaving 8937 our...
In atrial fibrillation (AF), a more extensively fibrotic left atrium (LA) provides substrate for arrhythmias and increases risk of relapse following ablation. Fibrocytes are bone marrow-derived circulating mesenchymal progenitors that have been identified in the patients with AF who valvular diseases. The present study investigates associations between fibrocytes LA fibrosis or prevalence recurrence after ablation persistent AF.We measured proportion, differentiation, migration from (n=40),...
PIGT encodes a subunit of the glycosylphosphatidylinositol transamidase complex, which catalyzes attachment proteins to GPI-anchors. A homozygous variant c.550G>A (p. E184K) in Chinese boy with multiple malformations, hypotonia, seizure and profound development delay was identified by panel sequencing. Pathogenicity confirmed flow cytometry. The expression CD16 CD24 this proband reduced 16.92 22.16% compare normal control respectively while his parents sister were normal. This mutation...
Atrial electrical remodeling (AER) is the underlying mechanism of atrial fibrillation (AF). The present study investigated impact epicardial fat pad (FP) ablation on acute AER (AAER) and inducibility AF.AAER was performed in 28 mongrel dogs through 4-h rapid pacing (RAP). Before RAP, 14 (ablation group) underwent FP ablation, other (control a sham procedure. effective refractory period (ERP) vulnerability window (VW) AF were measured with without bilateral cervical vagosympathetic nerve...
Background The Cardiovascular Health (CVH) Score was comprised of a series modifiable lifestyle and health factors, which published by American Heart Association in 2010. Its relationship with atrial fibrillation (AF) remains unclear. Hypothesis Individuals higher CVH had lower risk AF. Methods Participants ≥40 years age were recruited from the Jidong community. Information regarding following 7 metrics, including smoking, body mass index, diet, physical activity, total cholesterol, fasting...
Backgrounds . Segmental and circumferential pulmonary vein isolations (SPVI CPVI) have been demonstrated to be effective therapies for paroxysmal atrial fibrillation (PAF). PVI is well established as the endpoint of different ablation techniques, whereas it may not completely account long‐term success. Methods 181 drug‐refractory symptomatic PAF patients were referred segmental or = 67; CPVI 114). Heart rate variability (HRV) was assessed before after final ablation. Results After following...
Abstract Objective Ablation index (AI) is an effective ablation quality marker. Impedance also important factor for lesion formation. The present study evaluated the influence of baseline impedance in effect atrial fibrillation (AF) guided by AI. Methods This was a retrospective study. 101 patients with paroxysmal AF (PAF) were enrolled. All underwent radiofrequency same AI strategy. strategy pulmonary vein (PV) isolation non-PV triggers ablation. points recorded. followed up every 3 months...
We assessed the impact of pre- and postprocedural plasma corin levels on recurrence atrial fibrillation (AF) after catheter ablation (CA).
This paper investigates the tracking problem for discrete-time multi-agent systems with a time-varying reference state. The control is designed based on event-triggered scheme, which can lead to significant reduction of information communication burden in network. To realize control, only between agent and its local neighbours needed, therefore, essentially distributed. A numerical example presented demonstrate effectiveness theoretical results.
Objective: A more extensively fibrotic left atrium contributes to atrial fibrillation (AF) occurrence, persistence, and recurrence. The soluble suppression of tumorigenicity 2 (sST2) has emerged as a ventricular biomarker for patients with heart failure. present study is investigate associations between circulating sST2 risk recurrence after ablation in AF patients. Methods: We measured the baseline plasma level from persistent ( n = 117) paroxysmal 93) Patients were followed up 15 months...
Introduction: Current knowledge of the relationship between normalized protein catabolic rate (nPCR) and dialysis adequacy is limited. Our study aimed to explore potential nPCR adequacy. Methods: In this cross-sectional study, we analyzed association with peritoneal in 266 continuous ambulatory (CAPD) patients (mean age 48.6 ± 13.1 years; 50.8% male). The were divided into two groups: a inadequacy group (total weekly Kt/V urea < 1.70) urea≥1.70). We then correlation patients' primary...