A5089405476- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Data Visualization and Analytics
- Caching and Content Delivery
- Cancer Research and Treatments
- Web Data Mining and Analysis
- Immunotherapy and Immune Responses
- Boron Compounds in Chemistry
- Hydrogels: synthesis, properties, applications
- Recommender Systems and Techniques
- Lanthanide and Transition Metal Complexes
- Extracellular vesicles in disease
- Service-Oriented Architecture and Web Services
- Advanced Neural Network Applications
- Analytical Chemistry and Sensors
- Topic Modeling
- Advanced MRI Techniques and Applications
- Cell Adhesion Molecules Research
- Boron and Carbon Nanomaterials Research
- Phytochemistry and Biological Activities
- Virus-based gene therapy research
- Computer Graphics and Visualization Techniques
Sichuan University
2016-2025
West China Hospital of Sichuan University
2024-2025
State Key Laboratory of Biotherapy
2016-2024
Second People’s Hospital of Yibin
2024
Guilin University of Technology
2024
Guangzhou University
2022-2024
Hunan University of Science and Technology
2020-2023
Beijing National Laboratory for Molecular Sciences
2023
Peking University
2019-2023
Xiamen University
2016-2022
Abstract An intelligent theranostic nanoplatform based on nanovalve operated metal–organic framework (MOF) core–shell hybrids, incorporating tumorous microenvironment‐triggered drug release, magnetic resonance imaging (MRI) guidance, sustained and effective chemotherapy in one pot is reported. The hybrids are constructed by an situ growth method, which Fe 3 O 4 particles with superior abilities of MRI separation form the core UiO‐66 MOF high loading capacity compose shell, then...
Polymer vesicles formed by a pair of oppositely charged poly(ethylene glycol) (PEG)-based block aniomer and homocatiomer, termed "PICsomes", have tunable size, are characterized unique semipermeable property due to the flexible hydrophilicity polyion complex (PIC) membranes. The PICsomes can encapsulate variety molecules in an inner aqueous phase just simple vortex mixing solution, expecting their utility as nanocontainers substances with biomedical interests. Here, we report on new...
Occult nodal metastases increase the risk of cancer recurrence, demoting prognosis and quality life patients. While targeted drug delivery by using systemically administered nanocarriers can potentially control metastatic disease, lymph node have been mainly dealt locally injecting nanocarriers, which may not always be applicable. Herein, we demonstrated that sub-50 nm polymeric micelles incorporating platinum anticancer drugs could target in a syngeneic melanoma model after systemic...
For systemic delivery of siRNA to solid tumors, a size-regulated and reversibly stabilized nanoarchitecture was constructed by using 20 kDa siRNA-loaded unimer polyion complex (uPIC) nm gold nanoparticle (AuNP). The uPIC selectively prepared charge-matched polyionic complexation poly(ethylene glycol)-b-poly(l-lysine) (PEG-PLL) copolymer bearing ∼40 positive charges (and thiol group at the ω-end) with single 40 negative charges. ω-end PEG-PLL further enabled successful conjugation uPICs onto...
Cancer multidrug resistance (MDR) could lead to therapeutic failure of chemotherapy and radiotherapy, has become one the main obstacles successful cancer treatment. Some advanced drug delivery platforms, such as inorganic nanocarriers, demonstrate a high potential for theranostic overcome cancer-specific limitation conventional low-molecular-weight anticancer agents imaging probes. Specifically, it achieve synergetic effects, demonstrating stronger killing effects MDR cells by combining...
Gadolinium (Gd) chelates-loaded nanocarriers have high potential for achieving magnetic resonance imaging (MRI)-guided Gd neutron capture therapy (GdNCT) of tumors. Herein, we developed calcium phosphate micelles hybridized with PEG-polyanion block copolymers, and incorporated the clinical MRI contrast agent Gd-diethylenetriaminepentaacetic acid (Gd-DTPA/CaP). The Gd-DTPA/CaP were nontoxic to cancer cells at concentration 100 μM based on Gd-DTPA, while over 50% killed by thermal irradiation...
Nanomedicines capable of smart operation at the targeted site have potential to achieve utmost therapeutic benefits. Providing nanomedicines that respond endogenous stimuli with an additional external trigger may improve spatiotemporal control their functions, while avoiding drawbacks from inherent tissue distribution. Herein, by exploiting permeabilization endosomes induced photosensitizer agents upon light irradiation, we complemented intracellular action polymeric micelles incorporating...
In this paper, we study teacher-student learning from the perspective of data initialization and propose a novel algorithm called Active Teacher <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> Source code are available at: https://github.com/HunterJLin/ActiveTeacher for semi-supervised object detection (SSOD). extends framework to an iterative version, where label set is partially initialized gradually augmented by evaluating three key...
Although esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers, there are major bottlenecks in its therapeutic approaches, primarily identification clinically relevant targets and lack effective targeted therapeutics. Herein, we identified hallmarks ESCC, namely, high T-lymphokine-activated killer cell-originated protein kinase (TOPK) expression human ESCC tumors correlation with poor patient prognosis hypoxia tumor microenvironment. We developed hypoxia-sensitive...
Engineering nanovaccines capable of targeting dendritic cells (DCs) is desperately required to maximize antigen cross-presentation effector immune cells, elicit strong responses, and avoid adverse reactions. Here, we showed that glucose transporter 1 (Glut-1) on DCs a reliable target for delivering antigens DCs, thus, versatile delivery strategy using glucosylated was developed DC-targeted tumor immunotherapy. The ovalbumin-loaded highly accumulated in lymph nodes efficiently engaged with...