A5100317653- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- RNA modifications and cancer
- Cancer Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Advanced Nanomaterials in Catalysis
- Boron and Carbon Nanomaterials Research
- DNA and Nucleic Acid Chemistry
- Advanced Drug Delivery Systems
- Neural dynamics and brain function
- Mental Health Research Topics
- Blind Source Separation Techniques
- Dendrimers and Hyperbranched Polymers
- Trace Elements in Health
- Histone Deacetylase Inhibitors Research
- Ion Channels and Receptors
- Neurobiology of Language and Bilingualism
- Single-cell and spatial transcriptomics
Innovation Center of NanoMedicine
2016-2025
Jilin Medical University
2023
Huazhong University of Science and Technology
2022
Tianjin Medical University
2022
Tianjin Anding Hospital
2022
Shandong Provincial Hospital
2022
Shandong First Medical University
2022
Anhui University
2018
The University of Tokyo
2012-2016
Graduate School USA
2015
Therapeutic nanoreactors are of increasing interest in precise cancer therapy, which have been explored to situ produce therapeutic compounds from inert prodrugs or intrinsic molecules at the target sites. However, engineering a nanoreactor with tumor activable cascade reactions for efficient cooperative therapy remains great challenge. Herein, we demonstrate polymersome acidity-responsive membrane permeability activate orchestrated treatment. The constructed responsive polyprodrug...
Polymer vesicles formed by a pair of oppositely charged poly(ethylene glycol) (PEG)-based block aniomer and homocatiomer, termed "PICsomes", have tunable size, are characterized unique semipermeable property due to the flexible hydrophilicity polyion complex (PIC) membranes. The PICsomes can encapsulate variety molecules in an inner aqueous phase just simple vortex mixing solution, expecting their utility as nanocontainers substances with biomedical interests. Here, we report on new...
Current strategies to direct therapy-loaded nanoparticles the brain rely on functionalizing with ligands which bind target proteins associated blood-brain barrier (BBB). However, such have significant brain-specificity limitations, as are not exclusively expressed at microvasculature. Therefore, novel exploit alternative characteristics of BBB required overcome nonspecific nanoparticle targeting periphery, thereby increasing drug efficacy and reducing detrimental peripheral side effects....
Nanomedicines capable of smart operation at the targeted site have potential to achieve utmost therapeutic benefits. Providing nanomedicines that respond endogenous stimuli with an additional external trigger may improve spatiotemporal control their functions, while avoiding drawbacks from inherent tissue distribution. Herein, by exploiting permeabilization endosomes induced photosensitizer agents upon light irradiation, we complemented intracellular action polymeric micelles incorporating...
Delivering therapeutic antibodies into the brain across blood–brain barrier at a level is promising while challenging approach in treatment of neurological disorders. Here, we present polymeric nanomicelle (PM) system capable delivering therapeutically effective levels 3D6 antibody fragments (3D6-Fab) parenchyma for inhibiting Aβ aggregation. PM assembly was achieved by charge-converting 3D6-Fab through pH-sensitive citraconylation to allow complexation with reductive-sensitive cationic...
In response to hypoxic stress, hypoxia-inducible factor (HIF)-1α is a critical transcription regulating fundamental cellular processes, and its elevated expression level activity are associated with poor outcomes in most malignancies. The Yin Yang 1 (YY1) an important negative regulator of the tumor suppressor p53. However, role YY1 under condition poorly understood. Herein, we show that inhibition reduced accumulation HIF-1α condition, consequently downregulated target genes. Interestingly,...
Nanomedicines capable of control over drug functions have potential for developing resilient therapies, even against tumors harboring recalcitrant cancer stem cells (CSCs). By coordinating interactions within the confined inner compartment core–shell nanomedicines, we conceived multicomponent nanomedicines directed to achieve synchronized and synergistic cooperation tumor as a strategy enhancing efficacy, overcoming resistance, eradicating CSCs. The approach was validated by using polymeric...
Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one the most critical issues for oligonucleotide therapeutics. Many previous studies encapsulated oligonucleotides into ~100-nm nanoparticles. However, such nanoparticles inevitably accumulate in liver and spleen. Further, some intractable cancers, e.g., tumours pancreas brain, have inherent barrier characteristics preventing penetration tumour microenvironments. Herein, we report an alternative approach...
Transient in situ stealth coating of liver sinusoids using two-armed PEG relocates nanomedicines from the to their targets.
Glioblastoma (GBM) is resistant to immune checkpoint inhibition due its low mutation rate, phosphatase and tensin homologue (PTEN)-deficient immunosuppressive microenvironment, high fraction of cancer stem-like cells (CSCs). Nanomedicines fostering immunoactivating intratumoral signals could reverse GBM resistance inhibitors (ICIs) for promoting curative responses. Here, we applied pH-sensitive epirubicin-loaded micellar nanomedicines, which are under clinical evaluation, synergize the...
Prevention of metastatic and local-regional recurrence cancer after surgery remains difficult. Targeting postsurgical premetastatic niche microresiduals presents an excellent prospective opportunity but is often challenged by poor therapeutic delivery into minimal residual tumors. Here, enzymatically transformable polymer-based nanotherapeutic approach presented that exploits matrix metalloproteinase (MMP) overactivation in tumor-associated tissues to guide the codelivery colchicine...
Organ‐selective targeting of mRNA polyplexes has been rarely explored despite the substantial potential polymer‐based systems in delivery. In this study, spleen‐selective delivery is achieved by employing engineering to coat them with poly(ethylene glycol) (PEG). approach, hybridized PEGylated complementary RNA oligonucleotides (PEG–OligoRNAs), followed addition linear poly(ethyleneimine). method, it ensured that nearly all added PEG strands bind polyplexes, thereby enabling precise control...
Adeno-associated viruses (AAVs) are increasingly used in gene therapy to treat debilitating genetic diseases. However, systemically administered AAVs often inactivated by neutralizing antibodies (NAbs), and high-dose administration of causes hepatotoxicity, which limits their effectiveness. To address these challenges, we present a sequential assembly technique based on tannic acid (TA) phenylboronic acid-conjugated polymers form AAV-loaded ternary complexes having core-shell structure with...
Protection of small interfering RNA (siRNA) against degradation and targeted delivery across the plasma endosomal membranes to final site interference (RNAi) are major aims for development siRNA therapeutics. Targeting folate receptor (FR)-expressing tumors, we optimized polyplexes by coformulating a folate-PEG-oligoaminoamide (for surface shielding targeting) with one three lipo-oligoaminoamides (optionally tyrosine-modified, optimizing stability size) generate ∼100 nm lipopolyplexes...