A5023674914- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Gut microbiota and health
- Cancer Research and Treatments
- Immune responses and vaccinations
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Helicobacter pylori-related gastroenterology studies
- Veterinary medicine and infectious diseases
- interferon and immune responses
- Carbon and Quantum Dots Applications
- Lymphoma Diagnosis and Treatment
- Eosinophilic Esophagitis
- Acute Myeloid Leukemia Research
City of Hope
2016-2024
City Of Hope National Medical Center
2018-2024
Beckman Research Institute
2016-2024
Shanghai Clinical Research Center
2023
Zhuhai People's Hospital
2023
Jinan University
2023
ShanghaiTech University
2023
Guangzhou University of Chinese Medicine
2020-2022
National Tsing Hua University
2015-2022
Kunming Institute of Zoology
2021
Dual-targeted delivery of drugs and energy by nanohybrids can potentially alleviate side effects improve the unique features required for precision medicine. To realize this aim, however, hybrids which are often rapidly removed from circulation piled up tumors periphery near blood vessels must address difficulties in low half-lives tumor penetration. In study, a sponge-inspired carbon composites-supported red cell (RBC) membrane that doubles as stealth agent photolytic carrier transports...
Theranostic nanohybrids are promising for effective delivery of therapeutic drug or energy and imaging‐guided therapy tumors, which is demanded in personalized medicine. Here, a size‐changeable graphene quantum dot (GQD) nanoaircraft (SCNA) that serves as hierarchical tumor‐targeting agent with high cargo payload developed to penetrate deliver anticancer into deep tumors. The composed ultrasmall GQDs (less than 5 nm) functionalized pH‐sensitive polymer demonstrates an aggregation transition...
A magneto-responsive energy/drug carrier that enhances deep tumor penetration with a porous nano-composite is constructed by using tumor-targeted lactoferrin (Lf) bio-gate as cap on mesoporous iron oxide nanoparticles (MIONs). With large payload of gas-generated molecule, perfluorohexane (PFH), and hydrophobic anti-cancer drug, paclitaxel (PTX), Lf-MIONs can simultaneously perform bursting gas generation on-demand drug release upon high-frequency magnetic field (MF) exposure. Biocompatible...
The tumor microenvironment affects the outcome of radiotherapy against head and neck squamous cell carcinoma (HNSCC). We recently found that tolerogenic myeloid cells accumulate in circulation HNSCC patients undergoing radiotherapy. Here, we analyzed tumor-containing lymph node biopsies collected from these patients. After 2 weeks radiotherapy, an increase tumor-associated macrophages (TAMs) with activated STAT3, while CD8+ T were reduced as detected using multiplex IHC. Gene expression...
Delivery of drug and energy within responsive carriers that effectively target accumulate in cancer cells promises to mitigate side effects enhance the uniquely therapeutic efficacy demanded for personalized medicine. To achieve this goal, however, these carriers, which are usually piled up at periphery tumors near blood vessel, must simultaneously overcome challenges associated with low tumor penetration transport sufficient cargos deep eradicate whole cells. Here, we report a sponge-like...
As one of the ligands aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its mechanism remains obscure. Authentically, can be alleviated by regulating differentiation naïve CD4+ T cells via AhR activation. So, our study planned prove hypothesis that baicalein protected mice against UC balance Th17/Treg Immunofluorescence and western blot results showed could promote...
T lymphocyte infiltration with immunotherapy potentially suppresses most devastating brain tumors. However, local immune privilege and tumor heterogeneity usually limit the penetration of cells therapeutic agents into tumors, leading to recurrence after treatment. Here, a rabies virus glycoprotein (RVG)-camouflaged gold yarnball (RVG@GY) that can boost targeting efficiency at via dual hierarchy- RVG-mediated spinal cord transportation, facilitating decrease for cell infiltration, is...
Growing evidence links the aggressiveness of non-Hodgkin's lymphoma, especially activated B cell-like type diffuse large cell lymphomas (ABC-DLBCLs) to Toll-like receptor 9 (TLR9)/MyD88 and STAT3 transcription factor signaling. Here, we describe a dual-function molecule consisting clinically relevant TLR9 agonist (CpG7909) inhibitor in form high-affinity decoy oligodeoxynucleotide (dODN). The CpG-STAT3dODN blocked DNA binding activity, thus reducing expression downstream target genes, such...
A donut-shaped nanostructure effectively approaches the tumor and offers burst penetrative delivery of a large payload drug to overcome heterogeneity.
ABSTRACT Currently, the potential role of alterations occurring in liver immune system and intestinal flora injury remains unknown. Our study aimed to explore impacts microbial barrier damage induced by ceftriaxone on immunity. We developed BALB/c mice model administering ceftriaxone. The was observed 16S rRNA, pathological changes intestines livers were detected H&E or transmission electron microscope. activation immunocytes tested Flow Cytometry; expression LPS, ALT, AST, IL-6 TNF-α...
A photoresponsive pea‐like capsule (nanopea) that also represents a photothermal agent is constructed by wrapping multiple polymer micelles (polyvinyl alcohol, PVA) in reduced graphene oxide nanoshells through double emulsion approach. Resulting nanopeas can transport PVA containing the fully concealed hydrophobic drug docetaxel (DTX) which be later released near‐infrared photoactuation trigger. Through integrating rod‐shaped adhesion and lactoferrin (Lf) targeting, nanopea enhances both...
To investigate the potential effects and mechanism of wogonin on dextran sulfate sodium (DSS)-induced colitis, 70 male mice were administered (12.5, 25, 50 mg·kg-1 ·d-1 , i.g.) for 10 days, meanwhile, in order to induce free drink 3% DSS 6 days. We found that could obviously ameliorate DSS-induced including preventing colon shortening inhibiting pathological damage. In addition, increase expression PPARγ, which not only restores intestinal epithelial hypoxia but also inhibits iNOS protein...
In this study, double‐emulsion capsules (DECs) capable of concealing drug‐incorporated targeted‐supermolecules are developed to achieve “on‐demand” supermolecule release and enhanced sequential targeting for magneto‐chemotherapy. These water‐in‐oil‐in‐water DECs less than 200 nm in diameter synthesized using a single component PVA (polyvinyl alcohol) polymer the magnetic nanoparticles, which encapsulating large quantities targeted supermolecules composed palitaxel‐incorporated...