A5077463854- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Advanced Nanomaterials in Catalysis
- Cancer, Hypoxia, and Metabolism
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Surfactants and Colloidal Systems
- Dendrimers and Hyperbranched Polymers
- Bone health and treatments
- Luminescence and Fluorescent Materials
- Metal-Organic Frameworks: Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Boron Compounds in Chemistry
- Characterization and Applications of Magnetic Nanoparticles
- Supramolecular Self-Assembly in Materials
- Advanced Photocatalysis Techniques
- Biopolymer Synthesis and Applications
- Immunotherapy and Immune Responses
- Polymer Nanocomposites and Properties
- Nanopore and Nanochannel Transport Studies
National Chung Hsing University
2010-2025
National Taipei University
2005-2025
Industrial Technology Research Institute
2019
National Tsing Hua University
2010-2018
Tsinghua University
2015
National Taiwan University of Science and Technology
2005-2009
Tatung University
2003
Therapeutic efficacy of glioblastoma multiforme (GBM) is often severely limited by poor penetration therapeutics through blood-brain barrier (BBB) into brain tissues and lack tumor targeting.In this regard, a functionalized upconversion nanoparticle (UCNP)-based delivery system which can target convert deep tissue-penetrating near-infrared (NIR) light visible for precise phototherapies on was developed in work.Methods: The UCNP-based phototherapy acquired assembly oleic acid-coated UCNPs...
To significantly promote tumor uptake and penetration of therapeutics, a nanovehicle system comprising poly(lactic-co-glycolic acid) (PLGA) as the hydrophobic cores coated with pH-responsive N-acetyl histidine modified D-α-tocopheryl polyethylene glycol succinate (NAcHis-TPGS) is developed in this work. The nanocarriers switchable surface charges response to extracellular acidity (pHe) were capable selectively co-delivering indocyanine green (ICG), photothermal agent, doxorubicin (DOX),...
Theranostic nanohybrids are promising for effective delivery of therapeutic drug or energy and imaging‐guided therapy tumors, which is demanded in personalized medicine. Here, a size‐changeable graphene quantum dot (GQD) nanoaircraft (SCNA) that serves as hierarchical tumor‐targeting agent with high cargo payload developed to penetrate deliver anticancer into deep tumors. The composed ultrasmall GQDs (less than 5 nm) functionalized pH‐sensitive polymer demonstrates an aggregation transition...
Abstract T lymphocytes play a central role in immunotherapy, utilizing physical interactions to actively inhibit the development of metastases. However, tumor immune privilege and heterogeneity pose challenges by protecting against attacks limiting cell infiltration into tumors, particularly invasive metastatic clusters. Here, penetrating magnetic particles (TUP) containing cascade‐responsive membrane‐mimetic copolymer (zwitterionic 2‐methacryloyloxyethyl...
Immunotherapy can potentially suppress the highly aggressive glioblastoma (GBM) by promoting T lymphocyte infiltration. Nevertheless, immune privilege phenomenon, coupled with generally low immunogenicity of vaccines, frequently hampers presence lymphocytes within brain tumors, particularly in tumors. In this study, membrane-disrupted polymer-wrapped CuS nanoflakes that penetrate delivery to deep tumors via releasing cell-cell interactions, facilitating near-infrared II (NIR II) photothermal...
Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However, the tumor environment, dendritic often exhibit impaired antigen presentation and adopt an immunosuppressive phenotype, which hinders their function reduces ability to efficiently present antigens. Here, dual catalytic oxide nanosponge (DON) doubling as remotely boosted catalyst inducer of programming DCs program therapy is reported. Intravenous delivery DON enhances accumulation via marginated...
Dual stimuli-responsive hollow nanogel spheres serving as an efficient intracellular drug delivery platform were obtained from the spontaneous coassociation of two graft copolymers into vesicle architecture in aqueous phase. Both comprise acrylic acid (AAc) and 2-methacryloylethyl acrylate (MEA) units backbone either poly(N-isopropylacrylamide) (PNIPAAm) alone or both PNIPAAm monomethoxypoly(ethylene glycol) (mPEG) chain segments grafts. The assemblies then subjected to covalent...
Hollow hybrid nanogels were prepared first by the coassembly of citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs, 44 wt %) with graft copolymer (56 comprising acrylic acid and 2-methacryloylethyl acrylate units as backbone poly(ethylene glycol) poly(N-isopropylacrylamide) grafts in aqueous phase pH 3.0 vesicle structure, followed situ covalent stabilization via photoinitiated polymerization MEA residues within vesicles. The resultant hollow nanogels, though slightly...
Indocyanine green (ICG), an FDA approved medical near-infrared (NIR) imaging agent, has been extensively used in cancer theranosis. However, the limited aqueous photostability, rapid body clearance, and poor cellular uptake severely restrict its practical applications. For these problems to be overcome, ICG-encapsulated hybrid polymeric nanomicelles (PNMs) were developed this work through coassociation of amphiphilic diblock copolymer poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)...
A novel drug delivery strategy featured with enhanced uptake of nanoparticles (NPs) by targeted tumor cells and subsequent intratumoral cellular hitchhiking chemotherapy to deep regions was described. The NP system obtained from assembly poly(lactic acid-co-glycolic acid)-grafted hyaluronic acid (HA-g-PLGA) together an anticancer drug, SN38, in aqueous phase, followed implementing the surface a layer methoxypoly(ethylene glycol)-b-poly(histamine methacrylamide) (mPEG-b-PHMA) via hydrophobic...
The transdermal delivery of therapeutic agents amplifying a local concentration active molecules have received considerable attention in wide biomedical applications, especially vaccine development and medical beauty. Unlike oral or subcutaneous injections, this approach can not only avoid the loss efficacy drugs due to liver’s first-pass effect but also reduce risk infection by injection. In study, magneto-responsive composite microneedle (MNs) with mesoporous iron oxide nanoraspberry...
Through hierarchically targeting bone matrix and tumor cells, PTX-carrying ALN/FA-nanoparticles substantially accumulate in metastases improve mice survival rate.
Abstract The recruitment of T lymphocytes holds great potential for suppressing the most aggressive glioblastoma (GBM) recurrence with immunotherapy. However, phenomenon immune privilege and generally low immunogenicity vaccines often reduce presence within brain tumors, especially in tumor clusters. In this study, an implantable self‐cascading catalytic therapy antigen capture scaffold (CAS) that can boost efficiency at post‐surgery antigens via urethane‐polyethylene glycol‐polypropylene...
Abstract: In this study, a novel pH-responsive cholesterol-PEG adduct-coated solid lipid nanoparticles (C-PEG-SLNs) carrying doxorubicin (DOX) capable of overcoming multidrug resistance (MDR) breast cancer cells is presented. The DOX-loaded SLNs have mean hydrodynamic diameter ~100 nm and low polydispersity index (under 0.20) with high drug-loading efficiency ranging from 80.8% to 90.6%. in vitro drug release profiles show that the exhibit pH-controlled behavior maximum minimum unloading...