A5044185349- Parvovirus B19 Infection Studies
- Dermatological and COVID-19 studies
- Systemic Lupus Erythematosus Research
- Nanoplatforms for cancer theranostics
- Aldose Reductase and Taurine
- Blood groups and transfusion
- Tryptophan and brain disorders
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Cancer-related cognitive impairment studies
- Peroxisome Proliferator-Activated Receptors
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac Fibrosis and Remodeling
- Attention Deficit Hyperactivity Disorder
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Pharmacological Receptor Mechanisms and Effects
- Viral Infections and Immunology Research
- Liver Diseases and Immunity
- Receptor Mechanisms and Signaling
- Lung Cancer Treatments and Mutations
Chung Shan Medical University
2016-2025
Chung Shan Medical University Hospital
2016-2025
Bipar
2015
Indiana University School of Medicine
2015
Asia University
2013
China Medical University
2008
National Tsing Hua University
1999-2007
Animal Technology Institute Taiwan
2002-2005
Objectives: The prevalence of insomnia is very high in our society. Although pharmacological treatment available, most hypnotics have been shown to alter sleep architecture and many adverse effects. Gabapentin was originally designed for antiepileptic therapy; however, some studies reported that its use increases slow-wave healthy volunteers or patients. Our goal evaluate the benefits gabapentin primary Methods: Eighteen patients with participated study. They received at least 4 weeks. All...
Evidence shows that women have lower tumour necrosis factor-alpha (TNF-alpha) levels and incidences of heart dysfunction sepsis-related morbidity mortality. To identify the cardioprotective effects precise cellular/molecular mechanisms behind estrogen receptors (ERs), we investigated 17beta-estradiol (E(2)) receptor alpha (ERalpha) on LPS-induced apoptosis by analyzing activation survival death signalling pathways in doxycycline (Dox)-inducible Tet-On/ERalpha H9c2 myocardial cells...
Mounting evidence has revealed the anti-cancer activity of various anti-viral drugs. Oseltamivir phosphate (OP), namely Tamiflu®, is routinely used to combat influenza infections. Although indicated effects OP in vitro and vivo, little information known about effect use on cancers humans. A nationwide population-based cohort study involving 13,977,101 cases with 284,733 receiving was performed examine association between using National Health Insurance Research Database Taiwan 2009 2018. The...
The role played by IGF-II in signal transduction through the IGF-II/mannose-6-phosphate receptor (IGF2R) heart tissue has been poorly understood. In our previous studies, we detected an increased expression of and IGF2R cardiomyocytes that had undergone pathological hypertrophy. We hypothesized after binding with IGF-II, may trigger intracellular signaling cascades involved progression pathologically cardiac this study, used immunohistochemical analysis human cardiovascular array to detect...
Abstract Probiotics are known to regulate host immunity by interacting with systemic and mucosal immune cells as well intestinal epithelial cells. Supplementation certain probiotics has been reported be effective against various disorders, including immune-related diseases. However, little is about the effectiveness of Lactobacillus paracasei GMNL-32 (GMNL-32), reuteri GMNL-89 (GMNL-89) L . GMNL-263 (GMNL-263) in management autoimmune diseases, especially lupus erythematosus (SLE). NZB/W F1...
Chronic alcohol consumption leads to steatohepatitis and cirrhosis. Naturally fermented noni juice (NJ) contains polyphenols, polysaccharides, some trace minerals. This study explored protective effects of NJ against chronic consumption. Mice were assigned randomly one the following groups: (1) control, control liquid diet distilled water; (2) alcohol, (3) Alc+NJ_1X, 5 mL NJ/kg BW; (4) Alc+NJ_2X, 10 (5) Alc+NJ_3X, 15 BW for 4 weeks. decreased (p < 0.05) serum AST, ALT, levels liver lipids,...
Accumulating evidence indicates that overconsumption of ethanol contributes in many ways to the pathogenesis hepatic injury. Although studies indicate taurine decreases lipogenesis, oxidative stress, and inflammatory cytokines, protective effect against alcohol-induced liver injury is still unclear. To clarify precise signaling involved beneficial on injury, rats were randomly divided into four treatment groups: (1) control (Ctl), (2) alcohol (Alc), (3) Alc+taurine (Tau), (4) Alc+silymarin...
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that characterised by a dysregulation of the immune system, which causes inflammation responses, excessive oxidative stress and reduction in number cluster differentiation (CD)4+CD25+forkhead box P3 (FoxP3)+ T cells. Supplementation with certain Lactobacillus strains has been suggested to be beneficial comprehensive treatment SLE. However, little known about effect mechanism on To investigate effects SLE, NZB/W F1 mice were...
Abstract Glioblastoma multiforme ( GBM ) is recognized as a most aggressive brain cancer with the worst prognosis and survival time. Owing to anatomic location of gliomas, surgically removing tumour very difficult avoiding damage vital regions during radiotherapy impossible. Therefore, therapeutic strategies for malignant glioma must urgently be improved. Recent studies have demonstrated that selective serotonin reuptake inhibitors SSRI s) cytotoxic effect on certain cancers. Considering...
Abstract Colorectal cancer (CRC) is a leading cause of cancer‐related death globally. Although surgery still the major method for CRC therapy, adoption alternative treatments, such as traditional Chinese medicine (TCM), treatment increasing. Our previous study has indicated anti‐breast activity T33 (a TCM formula). Interestingly, ingredient in T33, Baishao (Paeoniae Radix Alba), was reported to have antiproliferative effects on cells. Therefore, this further validated influences HT‐29 and...
In previous studies, we have found that IGF-II and receptor (IGF-IIR) dose dependently correlated with the progression of pathological hypertrophy after complete abdominal aorta ligation, which may play a critical role in angiotensin II-induced cardiomyocyte apoptosis. However, detail mechanisms IGF-IIR regulation cell apoptosis response to remain unclear. By using IGF-IR short hairpin RNA inhibit expression Leu27 analog activate specifically IGF-IIR, investigated IGF-II/IGF-IIR activation...
Garlic oil has been reported to protect the cardiovascular system; however, effects and mechanisms behind cardioprotection of garlic on diabetes-induced cardiaomyopathy are unclear. In this study, we used streptozotocin (STZ)-induced diabetic rats investigate whether could heart from cardiomyopathy. Wistar STZ-induced received (0, 10, 50 or 100 mg kg(_1) body weight) by gastric gavage every 2 days for 16 days. Normal without diabetes were as control. Cardiac contractile dysfunction cardiac...