A5100329495- Ovarian cancer diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Optical Coherence Tomography Applications
- CCD and CMOS Imaging Sensors
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Orbital Angular Momentum in Optics
- Retinal Imaging and Analysis
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Sphingolipid Metabolism and Signaling
- Phagocytosis and Immune Regulation
- Conservation Techniques and Studies
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Medicinal Plants and Neuroprotection
Sir Run Run Shaw Hospital
2024-2025
Zhejiang University
2024-2025
Heriot-Watt University
2025
Beijing Institute of Technology
2023-2025
Shanghai University of Traditional Chinese Medicine
2025
Xi'an Medical University
2021-2025
Soochow University
2014-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Guangzhou Medical University
2021-2022
Guangxi Medical University
2020-2022
NASH is a highly prevalent metabolic syndrome that has no specific approved agents up to now. BBBP, which mainly contains bile acids, possess various pharmacological properties and some acids are available for treatment. Herein, the therapeutic effects underlying mechanisms of BBBP against were systemically evaluated. In this study, mice received an HFHS diet over 20-week period induce with or without intervention used evaluate effect NASH. Our results demonstrated attenuated hepatic...
Abstract Each photon in a vortex beam carries an orbital angular momentum (OAM). OAM detection plays very important role unlocking the new capability of beams both fundamental research and technological advancements. As number information channels continues to grow, there is urgent need improve sorting system. The unprecedented optical metasurfaces has provided opportunity realize compact platform. Different modes are typically separated into distinct light spots sorting. However, each spot...
BACKGROUND Gastric signet ring cell carcinoma (GSRC) is a distinctive type of gastric cancer. It mucus-secreting adenocarcinoma that may progress to distant metastasis at an early stage. Because poor differentiation, aggressive invasion, rapid progression, and other high-risk characteristics, surgical intervention should be prioritized. AIM To explore the clinical efficacy fluorouracil (5-FU) combined with paclitaxel oxaliplatin for treatment advanced GSRC. METHODS A total 85 patients GSRC...
Cyclophosphamide (CTX) often induces oocyte and granulosa cell injury, leading to fertility loss in young female cancer survivors. Deciphering the mechanisms underlying follicular injury could offer novel insights into preservation. Granulosa cells represent most abundant type within follicles can be generally categorized as cumulus (CGCs) mural (MGCs). Despite essential roles of supporting ovarian function physiological conditions, their distinct lineage-specific responses CTX remains...
Abstract Objectives To assess the clinical value of early clearance HE4 and CA125 for platinum sensitivity prognosis in patients with ovarian cancer. Method including data 89 cancer were collected. The assessed base on sensitivity, two-year PFS, PFS OS. Results Sixteen classified as resistant 73 sensitive according to response platinum-base chemotherapy. When after 3rd cycle chemotherapy or 1st chemotherapy, it gave highest AUC 0.788, 100% 57.5% specificity respectively between group. In...
Alzheimer's disease (AD) is a neurodegenerative that characterized by the accumulation of senile plaque and neurofibrilary tangle formation in brain, including cerebral cortex hippocampus. Nowadays, first-line treatment for AD application acetylcholinesterase inhibitors. However, inhibitors are basically anti-symptomatic limited aspect pathology associated with serious side-effects. With advantage multiple targets, pathways systems, Chinese herbal compounds hold promising potential...
The classification models were constructed to discover neuroprotective compounds against glutamate or H<sub>2</sub>O<sub>2</sub>-induced neurotoxicity through machine learning approaches.
Data proliferation in the digital age necessitates robust encryption techniques to protect information privacy. Optical leverages multiple degrees of freedom inherent light waves encode with parallel processing and enhanced security features. However, implementations large-scale, high-security optical have largely remained theoretical or limited simulations due hardware constraints, signal-to-noise ratio challenges, precision fabrication encoding elements. Here, we present an platform...
Abstract Targeting cyclin‐dependent kinases (CDKs) is a promising method of therapy for cancer. Unfortunately, the efficacy CDK inhibitors in hepatocellular carcinoma (HCC) limited, due part to incomplete understanding cell cycle progression and lack specific biomarkers adequately identify which patients may be responsive inhibitors. In present study, we report that microtubule‐associated protein RP/EB family member 1 (MAPRE1), gene involved microtubule regulation, significantly increased...
To investigate the potential effects and mechanism of wogonin on dextran sulfate sodium (DSS)-induced colitis, 70 male mice were administered (12.5, 25, 50 mg·kg-1 ·d-1 , i.g.) for 10 days, meanwhile, in order to induce free drink 3% DSS 6 days. We found that could obviously ameliorate DSS-induced including preventing colon shortening inhibiting pathological damage. In addition, increase expression PPARγ, which not only restores intestinal epithelial hypoxia but also inhibits iNOS protein...
What molecular mechanisms underlie the decline in ovarian reserve as number and quality of oocytes decrease patients with endometriomas (OEM)?
Carmustine is one of the alkylating chemotherapeutic agents, which are used to treat various types cancers, such as brain tumors, Hodgkins and non-Hodgkins lymphoma multiple myeloma. However, carmustine has side effect thrombocytopenia, mechanism not completely understood. In this study, we show that dose-dependently induced depolarization mitochondrial inner transmembrane potential (ΔΨm), up-regulation Bax, down-regulation Bcl-2 caspase-3 activation. did induce surface expression P-selectin...
BACKGROUND Targeting of PD-1/PD-L1 immune checkpoints exhibits excellent clinical outcomes in numerous types solid tumors, including gastric cancer. However, the tumor microenvironment cancer is very complex and association PD-L1 with still not clear. MATERIAL AND METHODS This study analyzed characteristics expression used immunohistochemistry to assess CD8 CD4 tumor-infiltrating leucocytes (TILs) 478 cases compared patterns 70 matched adjacent tissues, 32 benign tissues. Standardized...
A dataset of 67 berberine derivatives for the inhibition butyrylcholinesterase (BuChE) was studied based on combination quantitative structure–activity relationships models, molecular docking, and dynamics methods. First, a series were reported, their inhibitory activities toward evaluated. By 2D‐ studies, best model built by partial least‐square had conventional correlation coefficient training set ( R 2 ) 0.883, cross‐validation 0.777, test 0.775. The also confirmed Y‐randomization...
Abstract Chemotherapy-induced ovarian damage and infertility are significant concerns for women of childbearing age with cancer; however, the underlying mechanisms still not fully understood. Our study has revealed a close association between epigenetic regulation cyclophosphamide (CTX)-induced damage. Specifically, CTX its active metabolite 4-hydroperoxy (4-HC) were found to increase apoptosis granulosa cells (GCs) by reducing EZH2 H3K27me3 levels, both in vivo vitro. Furthermore, RNA-seq...
BACKGROUND Apoptosis plays an important role in the physiology of platelet function. We aimed to detect effect integrin αIIbβ3 inhibitor, tirofiban, on apoptotic events, including mitochondrial inner-membrane potential (ΔΨm), phosphatidylserine (PS) exposure surface, and generation reactive oxygen species (ROS), when washed platelets were stimulated with thrombin. MATERIAL AND METHODS The study included from healthy humans, divided into 4 groups: vehicle, tirofiban (0.05 μg/ml, 0.25 0.5...
Transforming growth factor β receptor (TGF-β1R) and tyrosine kinases (RTKs), such as VEGFRs, PDGFRs FGFRs are considered important therapeutic targets in blocking myofibroblast migration activation of idiopathic pulmonary fibrosis (IPF). To screen design innovative prodrug to simultaneously target these four classes receptors, we proposed an approach based on network pharmacology combining virtual screening machine learning activity prediction, followed by efficient vitro vivo models...
Alantolactone (ALT), a sesquiterpene lactone compound isolated from Inula helenium L., has recently attracted much attention for its anti-tumor properties. ALT reportedly functions by regulating the Akt pathway, which been shown to be involved in programmed platelet death (apoptosis) and activation. However, precise effect of on platelets remains unclear. In this study, washed were treated with vitro, apoptotic events activation detected. vivo, transfusion experiments employed detect...
Abstract Image sensing often relies on a high-quality machine vision system with large field of view and high resolution. It requires fine imaging optics, has computational costs, communication bandwidth between image sensors computing units. In this paper, we propose novel image-free framework for resource-efficient classification, where the required number measurements can be reduced by up to two orders magnitude. proposed single-pixel detection, optical target is first scattered an...