A5100434086- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Reproductive Biology and Fertility
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Ectopic Pregnancy Diagnosis and Management
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Plant biochemistry and biosynthesis
- Acute Lymphoblastic Leukemia research
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Antioxidant Activity and Oxidative Stress
- Cardiac tumors and thrombi
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Pediatric Pain Management Techniques
- Long-Term Effects of COVID-19
- Nanoparticle-Based Drug Delivery
- Multiple Myeloma Research and Treatments
- Dental Anxiety and Anesthesia Techniques
- COVID-19 diagnosis using AI
- Hydrogels: synthesis, properties, applications
- Stroke Rehabilitation and Recovery
Sir Run Run Shaw Hospital
2017-2024
Zhejiang University
2014-2024
Shenyang Pharmaceutical University
2024
Wuhan University
2022-2024
Wenzhou Medical University
2024
First Affiliated Hospital Zhejiang University
2015-2024
Peking University People's Hospital
2020-2023
Peking University
2020-2023
Shanghai Sixth People's Hospital
2023
Wuhan Children's Hospital
2023
Photodynamic therapy (PDT) is a promising singlet oxygen ((1)O2) mediated clinical treatment for many tumors. As the source of (1)O2, plays an important role in curative effect PDT. However, facts photochemical depletion and intrinsic hypoxic microenvironment tumors remain major challenges. In this work, novel photosensitizer carrier with self-compensating ability was designed It synthesized via chemical conjugation hemoglobin (Hb) to polymeric micelles formed by triblock copolymers...
Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention (PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling contribute poor prognosis rehabilitation AMI patients. We revealed effects HSP47 on myocardial ischemia-reperfusion (IRI) shed light underlying molecular mechanism. generated adult mice with lentivirus-mediated or miRNA (mi1/133TS)-aided fibroblast-selective overexpression. Myocardial IRI was induced by 45-min...
Abstract Introduction Behavior management of children during dental treatment is an important but challenging issue. As a new technique, VR has been applied in pediatric anxiety. But there no final conclusion whether reduces children's Methods The aim the study to assess effectiveness digital intervention using virtual reality (VR) helmets on anxiety, pain perception, and behavior triggered for children, as well occurrence simulator sickness local anesthesia primary teeth extraction. A total...
Ischaemia/reperfusion (I/R) injury is an important complication of reperfusion therapy for acute myocardial infarction, extremely compromising the cardiac benefits revascularization; however, specific and efficient treatment I/R still lacking. Isthmin-1 (ISM1) a novel adipokine plays indispensable roles in regulating glycolipid metabolism cell survival. The present study aims to investigate potential role molecular mechanism ISM1 using gain- loss-of-function approaches.
Background Adverse left ventricular remodeling and subsequent heart failure remain a major cause of patient morbidity mortality worldwide. The KLF family transcription factors plays crucial roles in injury. KLF12 (Krüppel‐like factor 12) is that regulates multiple disease processes, although the specific role cardiac remains unclear. Methods Results In our study, we observed significant upregulation expression hearts. increased primarily originated from fibroblasts during fibrotic response...
Abstract The mortality of coronavirus disease 2019 (COVID-19) differs between countries and regions. This study aimed to clarify the clinical characteristics imported second-generation cases in Shaanxi. included 134 COVID-19 Shaanxi outside Wuhan. Clinical data were compared severe non-severe cases. We further profiled dynamic laboratory findings some patients. In total, 34.3% patients cases, 11.2% had complications. As 7 March 2020, 91.8% discharged one patient (0.7%) died. Age, lymphocyte...
Abstract Background The mortality of COVID-19 differs between countries and regions. By now, reports on are largely focused first-generation cases. This study aimed to clarify the clinical characteristics imported second-generation Methods retrospective, multicenter cohort included 134 confirmed cases from 9 cities outside Wuhan. Epidemiological, outcome data were extracted medical records compared severe non-severe We further profiled dynamic laboratory findings some patients. Results 34.3%...
Graft copolymer dextran-<italic>g</italic>-poly(NIPAAm) was synthesized <italic>via</italic> SET-LRP and covalently attached to bovine hemoglobin form thermo-responsive protein–polymer conjugates as novel oxygen carriers.
Glyco-nanogels are glycopolymer-decorated nanoparticles of three-dimensional cross-linked networks, which have attracted ever-increasing interest the biomedical-related community. However, most current reported glycosylated nanogels prepared by copolymerization glycopolymers with co-monomers and cross-linkers. Physically self-assembled glyco-nanogels remain a big challenge rarely explored. Herein, we report new synthesis polyelectrolyte (glyco/CS nanogels), from (PMAG-b-PMAA) synthesized...
What molecular mechanisms underlie the decline in ovarian reserve as number and quality of oocytes decrease patients with endometriomas (OEM)?