A5086926765- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Chemotherapy-induced cardiotoxicity and mitigation
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Signaling Pathways in Disease
- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Paraoxonase enzyme and polymorphisms
- Heart Failure Treatment and Management
- RNA Research and Splicing
Renmin Hospital of Wuhan University
2022-2025
Wuhan University
2022-2025
Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention (PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling contribute poor prognosis rehabilitation AMI patients. We revealed effects HSP47 on myocardial ischemia-reperfusion (IRI) shed light underlying molecular mechanism. generated adult mice with lentivirus-mediated or miRNA (mi1/133TS)-aided fibroblast-selective overexpression. Myocardial IRI was induced by 45-min...
A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptor agonist, tirzepatide (LY3298176, TZP), has been developed to treat Type 2 diabetes mellitus (T2DM). In ischaemic heart diseases, TZP is involved in cardiac metabolic processes. However, its efficacy safety treating failure (HF) following myocardial infarction (MI) remain uncertain. Herein, 12 week C57BL/6J mice were subjected MI surgery, followed by administration of TZP. The effects on function...