A5103027257- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Child and Adolescent Psychosocial and Emotional Development
- Sepsis Diagnosis and Treatment
- Youth Substance Use and School Attendance
- Cardiac Fibrosis and Remodeling
- Intensive Care Unit Cognitive Disorders
- Diabetes Treatment and Management
- Lung Cancer Treatments and Mutations
- Suicide and Self-Harm Studies
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Genetic factors in colorectal cancer
- Cutaneous Melanoma Detection and Management
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Signaling Pathways in Disease
- Receptor Mechanisms and Signaling
- Cardiac Imaging and Diagnostics
- Inflammasome and immune disorders
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
Wuhan University
2021-2025
Renmin Hospital of Wuhan University
2021-2025
Xijing Hospital
2025
Air Force Medical University
2025
Jinan University
2018-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2018-2024
Fudan University
2024
Peking University
2009-2023
Albert Einstein College of Medicine
2021
Montefiore Medical Center
2021
BACKGROUND: The majority of people with diabetes are susceptible to cardiac dysfunction and heart failure, conventional drug therapy cannot correct diabetic cardiomyopathy progression. Herein, we assessed the potential role therapeutic value USP28 (ubiquitin-specific protease 28) on metabolic vulnerability cardiomyopathy. METHODS: type 2 mouse model was established using db/db leptin receptor–deficient mice high-fat diet/streptozotocin–induced mice. Cardiac-specific knockout in background...
The objective is to examine incidence, prevalence, and persistence of restricted or short sleep among adolescents associated risk factors. Data are from a sample 4,175 youths aged 11 17 at baseline 3,134 followed up 1 year later. Restricted was defined as 6 hr less per night. Prevalence 20%, 1-year incidence 17%, chronicity 54%. Analyses identified few independent predictors: female, older age, schoolwork, extracurricular activities, life stress. Odds ratios for restriction on weeknights...
Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention (PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling contribute poor prognosis rehabilitation AMI patients. We revealed effects HSP47 on myocardial ischemia-reperfusion (IRI) shed light underlying molecular mechanism. generated adult mice with lentivirus-mediated or miRNA (mi1/133TS)-aided fibroblast-selective overexpression. Myocardial IRI was induced by 45-min...
In recent years, with the developing of living standard, hyperlipidemia becomes second major reason acute pancreatitis. It is important to predict severity and prognosis at early stage hyperlipidemic pancreatitis (HLAP). We compared BISAP, Ranson, MCTSI, APACHE II scoring system in predicting MSAP SAP, local complications, mortality HLAP. A total 326 diagnosed patients from August 2006 July 2015 were studied retrospectively. Our result showed that all four systems can be used severity,...
A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptor agonist, tirzepatide (LY3298176, TZP), has been developed to treat Type 2 diabetes mellitus (T2DM). In ischaemic heart diseases, TZP is involved in cardiac metabolic processes. However, its efficacy safety treating failure (HF) following myocardial infarction (MI) remain uncertain. Herein, 12 week C57BL/6J mice were subjected MI surgery, followed by administration of TZP. The effects on function...
Abstract The goal of this study was to estimate incidence adolescent suicide attempts and predictors attempts. Data were collected using diagnostic interviews questionnaires with a sample 4,175 youths 11–17 3,134 followed-up year later. Total 0.95% first 0.84% for We found few significant independent Multivariate analyses identified only 2 (marijuana use caregiver attempts). did find evidence cumulative effects risk factors, increased odds increasing number factors. difficulty in identifying...
Background Mechanistic insights of glucagon-like peptide-1 receptor agonists remain incompletely identified, despite the efficacy in heart failure observed clinical trials. Here, we evaluated effects dulaglutide on complications and illuminated its underlying mechanism. Methods Results We used mice with high-fat diet (HFD)/streptozotocin-induced type 2 diabetes to investigate upon diabetic cardiac dysfunction. After onset diabetes, control were injected subcutaneously either (type...
Based on the demonstration of a circadian rhythm in human oral mucosa cell cycle, with most cells G2/M phase afternoon and at night, present study evaluated severity acute radiation esophagitis treatment outcomes esophageal squamous carcinoma patients receiving radiotherapy (RT) daytime versus evening. From 488 eligible concurrent chemoradiotherapy (CCRT), 369 received RT (before 19:00) 119 evening (after 19:00). The grades (Common Terminology Criteria for Adverse Events version 5.0)...
Although the pathogenesis of Hodgkin disease (HD) remains unknown, results epidemiologic studies suggest that heritable factors are important in terms susceptibility. Polymorphisms DNA repair genes may contribute to individual susceptibility for development different cancers. However, authors' knowledge, few date have investigated role such polymorphisms as risk HD.The authors evaluated relation between 3 nucleotide excision pathway (XPD [Lys751Gln], XPC [Lys939Gln], and XPG [Asp1104His]),...
ABSTRACT β 3 -adrenergic receptor (β -AR) has been proposed as a new therapy for several myocardial diseases. However, the effect of -AR activation on sepsis-induced apoptosis is unclear. Here, we investigated cardiomyocyte and cardiac dysfunction in cecal ligation puncture (CLP)-operated rats lipopolysaccharide (LPS)-treated cardiomyocytes. We found that existed both adult rat ventricular myocytes (ARVMs) H9c2 cells. The expression was upregulated LPS-treated ARVMs heart CLP rats....
Myocardial reperfusion injury occurs when blood flow is restored after ischemia, an essential process to salvage ischemic tissue. However, this phenomenon intricate, characterized by various harmful effects. Tissue damage in ischemia-reperfusion arises from factors, including the production of reactive oxygen species, sequestration proinflammatory immune cells tissues, induction endoplasmic reticulum stress, and occurrence postischemic capillary no-reflow. Secretory phospholipase A2 (sPLA2)...
Background Inflammation and metabolic disturbances are key culprits in the pathogenesis of obesity‐associated cardiomyopathy. The NLRP3 (nucleotide‐binding oligomerization domain‐like receptor 3) inflammasome mediates release proinflammatory cytokines IL‐1β (interleukin‐1β) IL‐18 by activating caspase‐1, which is strongly implicated disturbances. We here sought to determine whether inhibition could ameliorate obesity cardiomyopathy if so, further explore its underlying mechanisms. Methods...
Protein kinase B (PknB) is one of the Mycobacterium tuberculosis serine/threonine protein kinases and has an essential role in sustaining mycobacterial growth. Here, we identified characterized a novel small molecule compound named IMB-YH-8 that inhibited PknB served as anti-mycobacteria lead compound. auto-phosphorylation phosphorylation GarA by dose-dependent manner. The did not inhibit human Akt1 or other M. except for highly homologous PknA. bound to with moderate affinity. Molecular...
Abstract Intrinsic cardiac adrenergic (ICA) cells regulate both developing and adult physiological pathological processes. However, the role of ICA in septic cardiomyopathy is unknown. Here we show that norepinephrine (NE) secretion from increased through activation Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-α production dysfunction by lipopolysaccharide (LPS). In cells, LPS activated TLR4-MyD88/TRIF-AP-1 signaling promoted NE biosynthesis expression tyrosine hydroxylase, but...
Increased inflammatory mediators produced by inflamed cells are often connected with pressure-induced cardiac remodelling and heart failure. Interleukin-21 (IL-21) serves as an immunomodulator involved in multiple pathological processes, while the role of IL-21 remains unclear.Cardiac function, CD4+T-cell infiltration, receptor expression levels were investigated a pressure overload mouse model induced aortic banding (AB) surgery. Western blotting qPCR used to detect effects on inflammation,...
It was demonstrated that α1 adrenergic receptor (α1-AR) activation by phenylephrine (PE) attenuated cardiac dysfunction in lipopolysaccharide (LPS)-challenged mice. However, it is unclear whether PE suppresses sepsis-induced cardiomyocyte apoptosis. Here, we investigated the effects of on apoptosis LPS-treated adult rat ventricular myocytes (ARVMs) and septic rats induced cecal ligation puncture. Cardiomyocyte caspase activity were detected TUNEL spectrophotometrical assay, respectively....
Hyperlipidemic acute pancreatitis (HLAP) is characterized by critical condition and high recurrence rate compared with non-HLAP. We conducted this study to investigate the value of body mass index waist-hip ratio in predicting severity local complications HLAP. 96 patients HLAP were categorized ratio, respectively. According index, they divided into 3 groups, including normal weight, overweight, obesity. central obesity group no group. The severity, complications, systematic HLAP, using...
Dobutamine (DOB) is recommended as an inotrope for septic patients with low cardiac output, but its long-term impact on sepsis-induced cardiomyopathy remains unclear. This study investigated the effect of DOB myocardial dysfunction and injury. Rats were exposed to cecal ligation puncture (CLP), intrinsic function, other organ functions, hemodynamics, inflammatory response, serum injury biomarkers, apoptosis, vascular permeability determined. At 6 h after CLP, left ventricular ±dP/dt...