Purpose: Kuiyangling is a traditional Chinese medicine formula used for the treatment of ulcerative colitis, but specific mechanism remains unclear. Imbalance in NETs regulation one important factors contributing to onset colitis (UC). The HuR/VDR signaling pathway plays significant role restoring intestinal mucosal barrier UC. aim this study explore colitis. Methods: A mouse model using 3% DSS water was considered, and model, normal, medium- (5 g·kg − 1 ) high-dose (10 ), mesalazine (50...

Ischemic colitis (IC) is a multifaceted condition that often manifests with nonspecific symptoms such as abdominal pain and bloody diarrhea, particularly in older adults vascular risk factors. Diagnosis supported by elevated levels of white blood cells, lactate, C-reactive protein (CRP). Computed tomography (CT) imaging typically reveals wall thickening fat stranding watershed areas. Colonoscopy may demonstrate mucosal erythema, ulceration, or necrosis. IC can be differentiated from...

Purpose: This study was conducted to explore the mechanism of Sijunzi Decoction (SJZ) in treatment ulcerative colitis (UC). Methods: The aimed investigate active components and targets SJZ UC by screening databases such as TCMSP, GeneCards, OMIM, Distinct, TTD, Drugbank. An online Venn tool, Cytoscape 3.7.2, Autodock Tools were used analyze targets. also a mouse model further effects SJZ. HE staining, immunofluorescence, ELISA, qPCR, Western blot detect various indices. Results: Eighty-three...

Kaempferol is a natural polyphenol in lots of Chinese herbs, which has shown promising treatment for gastric cancer (GC). However, the molecular mechanisms its action have not been systematically revealed yet. In this work, network pharmacology approach was used to elucidate potential kaempferol GC.The input into PharmMapper and SwissTargetPrediction database get targets, targets GC were obtained by retrieving Online Mendelian Inheritance Man (OMIM) database, MalaCards Therapeutic Target...

In this study, Chinese herbal compound prescriptions combined with medicine powder were evaluated for the treatment of chronic atrophic gastritis erosion.This multi-center, randomized, positive drug control clinical trial randomly assigned 216 patients erosion to three groups: (1) group: aluminum plus magnesium suspension thrice per day 4 weeks; (2) test group 1: twice a Sanqi (Panax notoginseng) (3) 2: and Zhebeimu (Fritillaria thunbergii Miq.) weeks. The primary endpoint (improvement...

Diabetic gastroparesis (DGP) is characterized by delayed gastric emptying of solid food. Nitrergic neuron-mediated fundus relaxation and intragastric peristalsis are pivotal for impaired in DGP. Transient receptor potential vanilloid 1 (TRPV1) ion channels expressed gastrointestinal vagal afferent nerves have a role relevant disorders. In this study, mice with high-fat diet (HFD)-induced type 2 diabetes mellitus (T2DM), associated gastroparesis, were used to determine the TRPV1 After feeding...

Amauroderma rugosum (Blume & T. Nees) Torrend (Ganodermataceae) is an edible mushroom with a wide range of medicinal values. Our previous publication demonstrated the therapeutic effects water extract A. (WEA) against gastric ulcers. However, protective ethanol (EEA) on mucosa and its major active constituents have not yet been elucidated.

The long-term colonization of Helicobacter pylori can cause various gastrointestinal diseases, and its high genetic variability is prone to antibiotic resistance leads failure clinical treatment. Intracellular survival also contributes the drug tolerance H. . Patchouli alcohol (PA) shows a highly efficient activity against in vitro vivo And this study aims explore whether PA reduce determine underlying mechanism. Checkerboard time–kill bactericidal curve assay reveal that combination...

Spasmolytic polypeptide-expressing metaplasia (SPEM) is characterized by mucus cell morphologies at the base of gastric glands, which considered advanced SPEM when accompanied with an increase in transcripts associated intestinal-type cancer. Weiwei decoction (WWD) was modified from "Si-Jun-Zi Tang," has been used for thousands years China against atrophy and metaplasia.To investigate effects potential mechanisms WWD SPEM.Liquid chromatography-mass spectrometry employed to analyze...

Large impacted or residual invisible common bile duct (CBD) stones after mechanical lithotripsy are challenging. We aimed to evaluate the feasibility and success rate of a new hybrid anchoring balloon-guided direct peroral cholangioscopy (POC) for these conditions using an ultraslim endoscope.Sixty-five patients with large CBD POC from July 2012 2016 were identified, including six cases in whom additional interventional procedure was required. There altogether 55 undergoing our device,...

Systemic injury plays a central role in severe acute pancreatitis (SAP). Retrograde biliopancreatic duct infusion of sodium taurocholate (NaT) is commonly used to establish SAP animal models. To better characterize the systemic this model, was induced Sprague-Dawley rats by NaT administration (3.5 or 5%), followed sacrifice at 3, 6, 9, 12, 24, 48 and 72 h. Normal saline as control Sham-operated rats. The mortality rate, ascites volume, serum ascitic fluid amylase lipase activities were...

Helicobacter pylori was classified by the World Health Organization as a class 1 carcinogen. The development of drug-resistant strains this pathogen poses serious threat to human health worldwide. cell invasion H. activates xenophagy in gastric epithelial cells mediating miR-30b/c, and emergence autophagosomes provides niche that enables survival intracellular promotes its drug resistance. This study revealed some clinical present much stronger invasive ability than standard strains....

Gastric cancer (GC) is the fifth most common cause of cancer‑associated deaths; however, its treatment options are limited. Despite clinical improvements, chemotherapy resistance and metastasis major challenges in improving prognosis quality life patients with GC. Therefore, effective prognostic biomarkers targets associated immunological interventions need to be identified. Solute carrier family 2 member (<em>SLC2A2</em>) may serve a role tumor development invasion. The present study aimed...

Intestinal metaplasia (IM) refers to the replacement of gastric epithelial cells by intestinal cells. This is often accompanied chronic atrophic gastritis (CAG), which a precancerous lesion cancer. The incidence rates CAG and IM are increasing gradually, generates an enormous economic burden individuals society. To explore pathogenesis with IM, we screened out differentially expressed gene olfactomedin 4 (OLFM4) bioinformatics constructed OLFM4-shRNA plasmid chitosan magnetic nanoparticles...

Persistent Helicobacter pylori infection causes a variety of gastrointestinal diseases and even gastric cancer. H. invades epithelial cells to survive proliferate, which is one the key factors in persistent colonization. A Published study has confirmed that can eliminate intracellular through xenophagy maintain balance. However, growing body evidences indicate inhibit by miRNA regulating expression autophagy-related genes. Through western blot analysis, mRFP-GFP-LC3 transfection assay,...

Li Chang decoction (LCD), a Chinese medicine formula, is commonly used to treat ulcerative colitis (UC) in clinics.This study aimed identify the major components LCD and its prototype metabolic rat biological samples.The chemical constituents were identified by establishing reliable ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF/MS) method. Afterwards, rats orally administered LCD, samples (plasma, urine, feces) collected...

BACKGROUND Gastric intestinal metaplasia (IM) is a precancerous lesion that associated with an elevated risk of gastric carcinogenesis. Weiwei Decoction (WWD) promising traditional Chinese herbal formula widely employed in clinical for treating IM. Previous studies suggested the potential involvement olfactomedin 4 (OLFM4)/nucleotide-binding oligomerization domain 1 (NOD1)/caudal-type homeobox gene 2 (CDX2) signaling pathway IM regulation. AIM To verify regulation OLFM4/NOD1/CDX2 IM,...

Mirizzi syndrome (MS) is an uncommon condition characterized by common hepatic duct (CHD) compression impacted gallbladder or cystic stones adjacent inflammation. To date, a standardized therapeutic strategy for MS has not been established yet, owing to its complex clinical presentation. Thus, researchers still have develop new optimized approaches solve this problem. Herein, we describe patient with refractory who underwent successful treatment novel hybrid anchoring balloon-guided direct...

Crohn's disease (CD) affecting the jejunum and ileum is uncommon its diagnosis can be challenging. This case report describes a 35 year old male patient who had been experiencing intermittent periumbilical pain, diarrhoea fever for five years. Despite undergoing gastroscopy, colonoscopy capsule endoscopy; no significant abnormalities were found. was seen at Shenzhen Hospital of Traditional Chinese Medicine; Shenzhen, China. However, underwent double-balloon enteroscopy (DBE), which revealed...

Collision tumors involving the small intestine, specifically combination of a hamartomatous tumor and lipoma, are extremely rare. To our knowledge, no previous case report has described collision composed two benign different origins in intestine.

A 65-year-old female with a history of chronic gastritis presented repeat epigastric pain and heartburn after meals. physical examination was unremarkable, other than mild fever tenderness. Laboratory data revealed leucocytosis 11,340/μl 86.8 % neutrophils, elevated γ-glutamyltransferase at 282.1 IU/l mildly abnormal AST 40.5 IU/l, ALT 74.9 total bilirubin 30.4 μmol/l (direct 9.4 μmol/l) amylase 202 IU/l. gastroscopy showed 4 mm fistula on the anterior wall proximal duodenal bulb, without...