A5100366072- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- PARP inhibition in cancer therapy
- Metal complexes synthesis and properties
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Colorectal Cancer Screening and Detection
- Crystal structures of chemical compounds
- Nanocluster Synthesis and Applications
- Glioma Diagnosis and Treatment
Shenzhen Pingle Orthopedic Hospital
2023-2025
Guangzhou University of Chinese Medicine
2022-2025
Huashan Hospital
2025
Fudan University
2025
Binzhou Medical University
2020-2025
Binzhou University
2020-2025
Nanjing University of Chinese Medicine
2025
First Affiliated Hospital of Jinan University
2024
Yangzhou University
2024
Tianjin Medical University Cancer Institute and Hospital
2022-2024
Mutant RAS has remained recalcitrant to targeted therapy efforts. We demonstrate that combined treatment with poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors and mitogen-activated protein kinase (MAPK) (MEK) evokes unanticipated, synergistic cytotoxic effects in vitro vivo multiple mutant tumor models across lineages where mutations are prevalent. The of PARP MEK inhibitor combinations independent BRCA1/2 p53 mutation status, suggesting the activity is likely be...
Progress in understanding tumor stromal biology has been constrained part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type-specific protein markers. Using RNA expression profiling, we identified the membrane leucine-rich repeat containing 15 (LRRC15) as highly expressed multiple solid indications normal tissue expression. LRRC15 was on many tumors (e.g., breast, head and neck, lung, pancreatic) well directly subset of cancer cells mesenchymal...
Abstract Costimulatory receptors such as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) play key roles in regulating the effector functions of T cells. In human clinical trials, however, GITR agonist antibodies have shown limited therapeutic effect, which may be due to suboptimal receptor clustering-mediated signaling. To overcome this potential limitation, a rational engineering approach is needed optimize agonist-based immunotherapies. Here we show bispecific...
Purpose: Kuiyangling is a traditional Chinese medicine formula used for the treatment of ulcerative colitis, but specific mechanism remains unclear. Imbalance in NETs regulation one important factors contributing to onset colitis (UC). The HuR/VDR signaling pathway plays significant role restoring intestinal mucosal barrier UC. aim this study explore colitis. Methods: A mouse model using 3% DSS water was considered, and model, normal, medium- (5 g·kg − 1 ) high-dose (10 ), mesalazine (50...
Background. Although a number of studies have used Medicare claims data to study trends and variations in breast cancer treatment, the accuracy completeness information on surgical treatment for not been validated. Objectives. This assessed surgery determine whether can serve as source augment collected by registries. Methods. We Surveillance, Epidemiology End Results (SEER) Cancer Registry-Medicare compared with recorded SEER registries 23,709 women diagnosed at ≥65 years age from 1991...
Abstract Although Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved in multiple diseases, including BRCA1/2 mutant breast cancer, responses are usually transient requiring the deployment of combination therapies for optimal efficacy. Here we thus explore mechanisms underlying sensitivity and resistance to PARPi using two intrinsically sensitive (T22) resistant (T127) syngeneic murine cancer models female mice. We demonstrate that tumor associated macrophages (TAM)...
Bintrafusp alfa (BA) is a bifunctional fusion protein designed for colocalized, simultaneous inhibition of two immunosuppressive pathways, transforming growth factor-β (TGF-β) and programmed death-ligand 1 (PD-L1), within the tumor microenvironment (TME). We hypothesized that targeting PD-L1 to by BA colocalizes TGF-β trap (TGF-βRII) TME, enabling it sequester in more effectively than systemic blockade, thereby enhancing antitumor activity.Multiple technologies were used characterize binding...
The combination of PD-1 blockade with neoadjuvant chemotherapy (NAC) has achieved unprecedented clinical success in non-small cell lung cancer (NSCLC) compared to NAC alone, but the underlying mechanisms by which augments effects remain incompletely elucidated. Single-cell RNA sequencing was performed on CD45+ immune cells isolated from surgically resected fresh tumors seven NSCLC patients receiving or pembrolizumab and (NAPC). Multiplex fluorescent immunohistochemistry FFPE tissues before...
Purpose: This study was conducted to explore the mechanism of Sijunzi Decoction (SJZ) in treatment ulcerative colitis (UC). Methods: The aimed investigate active components and targets SJZ UC by screening databases such as TCMSP, GeneCards, OMIM, Distinct, TTD, Drugbank. An online Venn tool, Cytoscape 3.7.2, Autodock Tools were used analyze targets. also a mouse model further effects SJZ. HE staining, immunofluorescence, ELISA, qPCR, Western blot detect various indices. Results: Eighty-three...
Ischemic colitis (IC) is a multifaceted condition that often manifests with nonspecific symptoms such as abdominal pain and bloody diarrhea, particularly in older adults vascular risk factors. Diagnosis supported by elevated levels of white blood cells, lactate, C-reactive protein (CRP). Computed tomography (CT) imaging typically reveals wall thickening fat stranding watershed areas. Colonoscopy may demonstrate mucosal erythema, ulceration, or necrosis. IC can be differentiated from...
Abstract Triple-negative breast cancer is a high-risk form of with high metastatic potential and lack effective therapies. Immunotherapy has shown encouraging clinical benefits, its efficacy in triple-negative affected by immunocyte infiltration the tumor microenvironment. PGAM1 key enzyme involved metabolism; however, role microenvironment remains unclear. In this study, we aimed to investigate determine inhibition combination anti–PD-1 immunotherapy. Our results showed that highly...
Background Red blood cell distribution width (RDW) is considered to be related coronary heart disease and failure all-cause mortality, but its relationship with acute ischemic stroke still unclear. In this study, we aimed explore the between RDW severity functional outcomes of stroke. Methods We retrospectively reviewed patients September 2016 January 2020. Demographic, clinical, complications, laboratory data, treatment were collected for all patients. Stroke evaluated by NIHSS score,...
Abstract Objectives An easy-to-implement MRI model for predicting partial response (PR) postradiotherapy diffuse intrinsic pontine glioma (DIPG) is lacking. Utilizing quantitative T2 signal intensity and introducing a visual evaluation method based on heterogeneity, compared radiomic models radiotherapy in pediatric patients with DIPG. Methods We retrospectively included brainstem gliomas aged ≤ 18 years admitted between July 2011 March 2023. Applying Response Assessment Pediatric...