A5026690025- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Immune responses and vaccinations
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
Tianjin Medical University Cancer Institute and Hospital
2022-2024
The combination of PD-1 blockade with neoadjuvant chemotherapy (NAC) has achieved unprecedented clinical success in non-small cell lung cancer (NSCLC) compared to NAC alone, but the underlying mechanisms by which augments effects remain incompletely elucidated. Single-cell RNA sequencing was performed on CD45+ immune cells isolated from surgically resected fresh tumors seven NSCLC patients receiving or pembrolizumab and (NAPC). Multiplex fluorescent immunohistochemistry FFPE tissues before...
CD3+CD56+ natural killer T (NKT)-like cells have an immune function of and NK cells, which play important role in antitumor antiviral responses. This study aims to establish a NKT-like cell model by simulating the memory effect induced cytokines IL-12, IL-15, IL-18 (IL-12/15/18) explore formation mechanism. Our found that IL-12/15/18 preactivated exhibited enhanced IFN-γ production response restimulation with for 6h on day 7. The intrinsic potential these trained was significantly improved,...
Background Immune checkpoint therapy, involving the programmed cell death 1 (PD-1) monoclonal antibody, has revolutionized treatment of cancer. Tertiary lymphatic structure (TLS) serves as an immune indicator to predict efficacy PD-1 antibody therapy. However, there is no clear result whether distribution, quantity, and maturity TLS can be effective indicators for predicting clinical anti-PD1 immunotherapy in patients with colorectal cancer (CRC). Methods Fifty-seven who underwent surgical...
Small cell lung cancer (SCLC) with high c-Myc expression is prone to relapse and metastasis, leading extremely low survival rate. Cyclin-dependent kinases 4 6 (CDK4/6) inhibitor Abemaciclib plays a key role in the treatment of tumors, but effects mechanisms on SCLC remain unclear. This study was analyze effect molecular mechanism inhibiting proliferation, migration invasion expression, view expanding new direction for reducing recurrence metastasis.Proteins interacting CDK4/6 were predicted...
e20584 Background: The combination of immune checkpoint inhibitors (ICIs) with chemotherapy (chemoimmunotherapy) in the neoadjuvant setting have achieved favorable clinical benefits non-small cell lung cancer (NSCLC), but underlying molecular mechanism has not been fully elucidated. Methods: To identify factors associated outcome, single-cell RNA/TCR sequencing was performed using 10x Genomics on CD45 + cells isolated from tumor and multiple immune-relevant tissues peripheral blood four...
Abstract The authors have requested that this preprint be removed from Research Square.