A5101459601- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Proteoglycans and glycosaminoglycans research
- Cancer Immunotherapy and Biomarkers
- Acute Kidney Injury Research
- Drug Transport and Resistance Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lipid metabolism and disorders
- Immunotherapy and Immune Responses
- Natural Compound Pharmacology Studies
- Glioma Diagnosis and Treatment
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Burn Injury Management and Outcomes
- Chemotherapy-induced organ toxicity mitigation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Research and Treatments
- Cancer therapeutics and mechanisms
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
State Key Laboratory for Innovation and Transformation of Luobing Theory
2024
Hebei Academy of Sciences
2023-2024
Third Xiangya Hospital
2023
Central South University
2023
Guangxi Medical University
2016-2022
Tianjin Medical University Cancer Institute and Hospital
2022
First Affiliated Hospital of GuangXi Medical University
2016
Shaoxing People's Hospital
2009
Nanchang University
2007
Heilongjiang University of Chinese Medicine
2005
Abstract Background Our previous bioinformatics-based study found that midkine (MDK) was associated with poor prognosis of glioblastoma (GBM). However, the mechanism MDK in GBM remains elusive. Methods A public GBM-related dataset and tissues from our center were used validate aberrant expression at RNA protein levels. The relationship between survival patients also explored through analysis. Subsequently, we identified MDK-related GBM-specific genes using differential Functional enrichment...
The combination of PD-1 blockade with neoadjuvant chemotherapy (NAC) has achieved unprecedented clinical success in non-small cell lung cancer (NSCLC) compared to NAC alone, but the underlying mechanisms by which augments effects remain incompletely elucidated. Single-cell RNA sequencing was performed on CD45+ immune cells isolated from surgically resected fresh tumors seven NSCLC patients receiving or pembrolizumab and (NAPC). Multiplex fluorescent immunohistochemistry FFPE tissues before...
Lung adenocarcinoma (LUAD) remains an incurable disease with a poor prognosis. This study aimed to explore neutrophil‑related genes (NRGs) and develop prognostic signature for predicting the prognosis of LUAD. NRGs were obtained by intersecting modular identified weighted gene co-expression network analysis (WGCNA) using bulk RNA-seq data marker neutrophils from single-cell RNA-sequencing(scRNA-seq) data. Univariate Cox regression, least absolute shrinkage selection operator (LASSO),...
Lianhua Qingke (LHQK) is an effective traditional Chinese medicine used for treating acute tracheobronchitis. In this study, we evaluated the effectiveness of LHQK in managing airway mucus hypersecretion exacerbation chronic obstructive pulmonary disease (AECOPD).The AECOPD model was established by subjecting male Wistar rats to 12 weeks cigarette smoke (CS) exposure (80 cigarettes/day, 5 days/week weeks) and intratracheal lipopolysaccharide (LPS) (200 μg, on days 1, 14, 84). The were...
Glioblastoma (GBM) is the most frequent malignant brain tumor in adults. Our study focused on uncovering differentially expressed genes (DEGs) and their methylation order to identify novel diagnostic biomarkers potential treatment targets. Using GBM RNA-sequencing data from The Cancer Genome Atlas (TCGA) database, DEGs between samples paracancer tissue were analyzed. Enrichment analysis for transcription factors (TFs) was performed. A total of 1029 upregulated 1542 downregulated identified,...
<b><i>Background/Aims: </i></b>Ischemia-reperfusion (IR) injury in the kidney is a major cause of acute humans. However, molecular mechanisms responsible for progression IR still need to be explored. In this study, we aimed explore underlying genes and pathways associated with injury. <b><i>Methods: </i></b>Gene microarray GSE27274 was downloaded from Gene Expression Omnibus database. The differentially expressed (DEGs) between rat samples were...
Glioblastoma (GBM) is the most common and deadly primary brain tumor in adults. Diagnostic therapeutic challenges have been raised because of poor prognosis. Gene expression profiles GBM normal tissue samples from GSE68848, GSE16011, GSE7696, The Cancer Genome Atlas (TCGA) were downloaded. We identified differentially expressed genes (DEGs) by differential analysis obtained 3,800 intersected DEGs all datasets. Enrichment revealed that involved MAPK cAMP signaling pathways. seven different...
Abstract Cuproptosis is a manner of cell death which related to the homeostasis copper ions in cellular environment and expected open new direction anti-tumor therapy. However, studies on cuproptosis lung adenocarcinoma (LUAD) are still limited. In this study, we identified genes (CHRGs) were effective stratifying genotyping clusters with survival differences based transcriptomic data obtained from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Weighted Co-expression Network...
畸胎瘤约占卵巢肿瘤的20%，其中99%卵巢畸胎瘤为成熟畸胎瘤。不同于未成熟畸胎瘤，成熟畸胎瘤多以囊性为主，成熟型实性畸胎瘤罕见。腹膜神经胶质瘤病（gliomatosis peritonei，GP）是以腹膜内成熟神经胶质结节为特征的病变，常与卵巢畸胎瘤（尤其不成熟畸胎瘤）有关，属于非常少见的一类疾病。GP多发生于10~20岁，多与体积较大畸胎瘤伴发，其成分以神经为主，主要分布于畸胎瘤周围腹膜及大网膜。该病例为37岁女性卵巢肿瘤患者，术前及术中临床及影像学提示卵巢癌可能。经充分取材，术后病理诊断为卵巢巨大实性成熟型畸胎瘤伴GP。.
As a previously discovered target of DNA damage, Na+/H+ exchanger 1 (NHE1) plays role in regulation intracellular pH (pHi) through the extrusion proton (H+) exchange for extracellular sodium (Na+). Its abnormal expression and dysfunction have been reported solid tumor hematopoietic malignancies. Here, we that suppression NHE1 BCR-ABL+ malignancies’ K562 cells treated with Etoposide was manipulated by miR-19 c-MYC. Inhibition or c-MYC enhanced sensitized to vitro. The vivo nude mouse...