A5002761664- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Amino Acid Enzymes and Metabolism
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Supramolecular Self-Assembly in Materials
- Electrospun Nanofibers in Biomedical Applications
- Virus-based gene therapy research
- Glycosylation and Glycoproteins Research
- Infectious Aortic and Vascular Conditions
- Aortic aneurysm repair treatments
- Bone health and treatments
- Polyamine Metabolism and Applications
- Porphyrin Metabolism and Disorders
- Fluorine in Organic Chemistry
- Nanopore and Nanochannel Transport Studies
- Aortic Disease and Treatment Approaches
- Boron Compounds in Chemistry
- Bone health and osteoporosis research
- Bone Tissue Engineering Materials
- Analytical Chemistry and Sensors
Life Science Institute
2017-2025
Innovation Center of NanoMedicine
2023-2025
Institute of Science Tokyo
2025
Tokyo Institute of Technology
2017-2024
Lipid nanoparticles (LNPs) coated with functional and biocompatible polymers have been widely used as carriers to deliver oligonucleotide messenger RNA therapeutics treat diseases. Poly(ethylene glycol) (PEG) is a representative material for the surface coating, but PEG surface-coated LNPs often reduced cellular uptake efficiency pharmacological activity. Here, we demonstrate effect of pH-responsive ethylenediamine-based polycarboxybetaines different molecular weights an alternative...
Adeno-associated viruses (AAVs) are increasingly used in gene therapy to treat debilitating genetic diseases. However, systemically administered AAVs often inactivated by neutralizing antibodies (NAbs), and high-dose administration of causes hepatotoxicity, which limits their effectiveness. To address these challenges, we present a sequential assembly technique based on tannic acid (TA) phenylboronic acid-conjugated polymers form AAV-loaded ternary complexes having core-shell structure with...
Tannic acid (TA) can form stable complexes with proteins, attracting significant attention as protein delivery systems. However, its systemic application has been limited due to nonspecific interaction. Here, we report a simple technique prepare systemically applicable systems using sequential self-assembly of protein, TA, and phenylboronic acid-conjugated PEG-poly(amino acid) block copolymers in aqueous solution. Mixing the TA solution led covering subsequent addition copolymer resulted...
Lipid nanoparticles (LNPs) have been commonly used as a vehicle for nucleic acids, such small interfering RNA (siRNA); the surface modification of LNPs is one determinants their delivery efficiency especially in systemic administration. However, applications siRNA-encapsulated are limited due to lack effective systems deliver solid tumors. Here, we report smart using charge-switchable ethylenediamine-based polycarboxybetaine enhancing tumor accumulation via interaction with anionic tumorous...
Abstract 5‐Aminolevulinic acid (5‐ALA) is an amino that can be metabolized into a photosensitizer, protoporphyrin IX (PpIX) selectively in tumor cell, permitting minimally invasive photodynamic diagnosis/therapy. However, some malignant cells have excess intracellular labile iron and facilitate the conversion of PpIX heme, which compromises therapeutic potency 5‐ALA. Here, we examined potential chelation such unfavorable intratumoral therapy (PDT) with 5‐ALA hydrochloride, using polymeric...
Increased glutamine uptake toward the elevated glutaminolysis is one of hallmarks tumour cells. This aberrant metabolism has recently attracted considerable attention as a diagnostic and therapeutic target. Herein, we developed glutamine-functionalized polymer to achieve selective high affinity cells overexpressing glutaminolysis-related transporter ASCT2. In in vitro study, our exhibited faster higher cellular than that normal Uptake inhibition study revealed dominant contribution ASCT2...
Abdominal aortic aneurysm (AAA) is a life-threatening disease. However, no systemically injectable drug has been approved for AAA treatment due to low bioavailability. Polymeric micelles are nanomedicines that have the potential improve therapeutic efficacy by selectively delivering drugs into disease sites, and research mainly focused on cancer treatments. Here, we developed statin-loaded polymeric micelle treat AAAs in rat models. The showed medicinal preventing expansion dose-dependent...
Abstract Nano‐sized contrast agents (NCAs) hold potential for highly specific tumor enhancement during magnetic resonance imaging. Given the quantity of loaded into a single nano‐carrier and anticipated relaxation effects, current molecular design approaches its limits. In this study, novel mechanism to augment NCAs is introduced demonstrated. NCA formation driven by intramolecular self‐folding polymer chain that possesses systematically arranged hydrophilic hydrophobic segments in water....
Polyzwitterions that show the alternation of net charge in response to external stimuli have attracted great attention as a new class surface-polymers on nanomedicines. However, correlation between their detailed molecular structures and expression antifouling properties under physiological condition remain controversial. Herein, we synthesized series ethylenediamine-based polyzwitterions with carboxy groups/sulfonic groups ethylene, propylene, butylene spacers potential for nanomedicines,...
Since the discovery of d-amino acids, they have been considered inactive and not used as potent drugs. Here, we report that simple mixing with poly(vinyl alcohol) (PVA) unleashed latent potentials acids in boron neutron capture therapy (BNCT). PVA formed boronate esters seemingly useless boronated induced tumor-associated amino acid transporter-superselective internalization prolonged intracellular retention, accomplishing complete cure tumors. The superselective was achieved by switching...
The construction of enzyme delivery systems, which can control enzymatic activity at a target site, is important for efficient enzyme-prodrug therapy/diagnosis. Herein we report facile technique to construct systemically applicable β-galactosidase (β-Gal)-loaded ternary complex comprising tannic acid (TA) and phenylboronic acid-conjugated polymers through sequential self-assembly in aqueous solution. At physiological conditions, the exhibited hydrodynamic diameter ∼40 nm protected loaded...
Transporter ASCT2, which predominantly imports glutamine (Gln), is overexpressed in a variety of cancer cells, and targeting ASCT2 expected to be promising approach for tumor diagnosis therapy. In this work, we designed series glutamine-modified poly(l-lysine) (PLys(Gln)) homopolymers PEG-PLys(Gln) block copolymers investigated their tumor-targeting abilities. With increasing degree polymerization the PLys(Gln) homopolymers, cellular uptake was gradually enhanced through multivalent...
Sustainable social activity is a major goal in an aging society, although this limited by loss of athleticism, with osteoporosis-related fractures being the most common cause long-term behavioral restrictions older people. Therefore, development therapeutics that shorten duration fracture therapy essential to improve quality life and individuals. In study, we developed polyethylene glycol-modified alendronate (PEG-ALN) can efficiently deliver active ingredient (ALN) sites. PEG-ALN released...