A5045893680- Genetic Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Metabolism and Genetic Disorders
- Muscle Physiology and Disorders
- Aortic aneurysm repair treatments
- Cardiomyopathy and Myosin Studies
- Mitochondrial Function and Pathology
- Hereditary Neurological Disorders
- Aortic Disease and Treatment Approaches
- Peroxisome Proliferator-Activated Receptors
- RNA regulation and disease
- Infectious Aortic and Vascular Conditions
- Neurological diseases and metabolism
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Neurological disorders and treatments
- Connective tissue disorders research
- Myasthenia Gravis and Thymoma
- Prion Diseases and Protein Misfolding
- Alcoholism and Thiamine Deficiency
- Nuclear Structure and Function
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Thallium and Germanium Studies
- Pharmacological Effects and Toxicity Studies
- Amyotrophic Lateral Sclerosis Research
The University of Tokyo
2019-2022
University of Tokyo Hospital
2019
Saigata National Hospital
1991-2002
Fukuoka University
2002
Niigata University
1979-1999
Kanazawa University
1985
In three familial cases and one sporadic case of late-onset distal myopathy, muscle wasting started in the portions lower extremities. The most striking change seen by light microscopy was appearance rimmed vacuoles. These were presumed to be autophagic, because they found electron contain membranous lamellar structures other heterogenous materials enclosed a limiting membrane. On hand, lysosomal activity markedly increased skeletal muscle. 6% 22% affected fibers there acid...
The authors describe a patient who had point mutation at codon 232 of the prion protein gene, resulting in substitution methionine for arginine (M232R). developed dementia and died 6 years after its onset. Autopsy revealed with Lewy bodies, not Creutzfeldt–Jakob disease. Although M232R has been reported to cause disease, findings our suggest that all patients presenting progressive have
Abdominal aortic aneurysm (AAA) is a life-threatening disease. However, no systemically injectable drug has been approved for AAA treatment due to low bioavailability. Polymeric micelles are nanomedicines that have the potential improve therapeutic efficacy by selectively delivering drugs into disease sites, and research mainly focused on cancer treatments. Here, we developed statin-loaded polymeric micelle treat AAAs in rat models. The showed medicinal preventing expansion dose-dependent...
We documented the presence of a point mutation in tRNA<sup>Lys</sup> gene mitochondrial DNA (mtDNA) various postmortem tissues from two patients with myoclonus epilepsy associated ragged-red fibers (MERRF). The percentages mutant mtDNA were similar (93 to 99%) both clinically affected and unaffected tissues, suggesting that preferential clinical involvement certain MERRF is based not only on variation distribution mtDNA, but also other factors such as differences threshold CNS regions organs.
Daily injection of methamphetamine (MAP) increased the locomotor activity and produced development MAP-induced anticipatory on next withdrawal day. restricted feeding also causes a feeding-associated rhythm. The importance catecholaminergic neurons has been suggested in manifestation corticosterone In our study, we examined role dopaminergic activity. was blocked by coadministration dopamine D2 receptor antagonists such as YM-09151-2 sulpiride, D1 antagonist SCH23390 haloperidol weak D1/D2...
To determine whether the nocturnal decrease in arginine vasopressin (AVP) secretion into plasma, found a patient with multiple system atrophy (MSA) reported previously, is usual finding MSA, plasma AVP concentrations 13 patients MSA were measured every 4 hours during 24 hour period. The these showed significant daily variations and lowest night. This indicates that often exhibit plasma. results suggest possibility responsible for involved MSA.
We used histologic evidence of degenerative changes in both the gray and white matter brain to diagnose a patient as having panencephalopathic type Creutzfeldt-Jakob disease (CJD). This CJD is relatively common Japan, but not North America or Europe. recovered transmissible pathogen (Echigo-1 strain) from an autopsy specimen patient9s passed it serially Hartley guinea pigs. After long latent period, caused changes, mainly thalamic area pig brain. On 4th passage, substrain emerged with short...