A5033546774- Cardiovascular Function and Risk Factors
- Heat shock proteins research
- Diversity and Career in Medicine
- Radiation Effects in Electronics
- Protein Structure and Dynamics
- RNA modifications and cancer
- Protein purification and stability
- Pulmonary Hypertension Research and Treatments
- Health and Medical Research Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Fibrosis and Remodeling
- RNA Research and Splicing
Washington University in St. Louis
2023-2025
University of Pittsburgh Medical Center
2021
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role more prevalent failure syndromes remains mechanistically unexamined. We observed mis-localization desmin sarcomeric proteins to human myocardium with ischemic mouse hearts post-myocardial infarction ventricular remodeling, mimicking findings autosomal-dominant induced by R120G mutation the cognate chaperone protein, CRYAB. In both syndromes, we demonstrate...
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role more prevalent failure syndromes remains mechanistically unexamined. We observed mis-localization desmin sarcomeric proteins to human myocardium with ischemic mouse hearts post-myocardial infarction ventricular remodeling, mimicking findings autosomal-dominant induced by R120G mutation the cognate chaperone protein, CRYAB. In both syndromes, we demonstrate...