A5103201131- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- interferon and immune responses
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Neuropeptides and Animal Physiology
- Cancer Immunotherapy and Biomarkers
- Gastroesophageal reflux and treatments
- Epigenetics and DNA Methylation
- Neonatal and Maternal Infections
- Hypothalamic control of reproductive hormones
- RNA Research and Splicing
- ZnO doping and properties
- Extracellular vesicles in disease
- Cancer, Stress, Anesthesia, and Immune Response
- Enhanced Recovery After Surgery
- Advanced Photocatalysis Techniques
- Covalent Organic Framework Applications
Nantong University
2023-2025
Changshu No.1 People's Hospital
2016-2025
Changshu No. 2 People's Hospital
2022
Xian Yang Central Hospital
2018-2021
Tianjin People's Hospital
2019-2021
Yangzhou University
2016-2018
Nankai University
2014
Second Xiangya Hospital of Central South University
2009
Central South University
2009
Chinese Academy of Sciences
1998
Abstract Colorectal cancer (CRC) is the second most common cancer‐related deaths throughout world. Ferroptosis a recently regulated form of cell death, lately gains attention. MicroRNA‐15a‐3p (miR‐15a‐3p) plays regulatory role in various kinds cancers. However, miR‐15a‐3p cellular ferroptosis still unclear. Here, we aimed to clarify whether could regulate CRC. Here identified positively regulates via directly targeting glutathione peroxidase 4 (GPX4) Overexpression repressed GPX4 through...
Increasing evidence indicates that elevated expression of enhancer zeste homolog 2 gene (EZH2) in many human malignant tumors acts a significant role the oncogenic process. However, underlying molecular mechanism is still unclarified. It evident apoptosis and autophagy tumor cells crucial for tumorigenesis progression cancer, however, exact EZH2 plays has not been fully elucidated colorectal cancer (CRC). Our previous study found level was higher CRC tissues than paired normal using...
<title>Abstract</title> MiR-195-5p has been confirmed to be intimately linked many cancers development, whereas its role in gastric cancer (GC) remains controversial. The objective of this study was explore the potential function and mechanism miR-195-5p GC. First, level GC analyzed based on qRT-PCR TCGA STAD. Then, cells detected via CCK-8, clone formation assay, flow cytometry, transwell, wound healing assay. Subsequently, we explored possible using KEGG analysis, database Western blot,...
We aimed to study the role of LINC00997 in metastasis colorectal cancer (CRC). and miR-512-3p expression primary (NCRC) tissues metastatic (MCRC) were detected using RT-qPCR. The Cancer Genome Atlas database was used evaluate levels NCRC MCRC tissues, correlations with distant (M), regional lymph node (N), age tumor stage analyzed. Subsequently, RT-qPCR performed determine metastasis-related genes analyze correlation or level protein genes. In vitro, several CRC cell lines examined. After...
Gastric cancer (GC) is a kind of malignancy originating from the epithelium gastric mucosa. Long noncoding RNAs (lncRNAs) are tightly related to GC progression. Herein, our research was meant investigate novel lncRNA thymidylate synthetase opposite strand (TYMSOS) in GC. Quantitative real-time polymerase chain reaction used analyze TYMSOS expression cells. 5-Ethynyl-2'-deoxyuridine, flow cytometry analysis, and transwell assay detected influence on cell proliferation, apoptosis, migration,...
Dysregulation of SUMO-specific protease 1 (SENP1) expression has been reported in several kinds cancer, including human colorectal and prostate cancers, proposing SENP1 as an oncogene with a critical role cancer progression. miR-133a-3p tumor suppressor malignant neoplasias. However, the precise molecular mechanisms underlying its remain largely unknown. The aim this work was to investigate relationship between cells. We found that downregulated tissues. In silico analyses indicated is one...
DNA‑damage regulated autophagy modulator 1 (DRAM1) is known as a target of TP53‑mediated autophagy, and has been reported to promote the migration invasion abilities glioblastoma stem cells. However, precise contribution DRAM1 cancer cell migration, underlying mechanisms remain unclear. In present study, small interfering (si)RNA or short hairpin RNA mediated knockdown was performed in hepatoblastoma cells were detected vitro vivo. To investigate mechanisms, western blotting...
In recent years, reports regarding stimulator of interferon genes (STING) and the progression colorectal cancer (CRC) have emerged rapidly, yet their association remains controversial. This research was aimed to provide an insight into prognostic biomarker therapeutic target significance STING in CRC.CRC Cell lines HCT116 SW480, as well 32 paired CRC specimens were chosen for this study. expressions examined by immunohistochemistry evaluate correlation with clinicopathological factors. Data...
Background: Knowledge about the prognostic role of long noncoding RNA (lncRNA) in colorectal cancer (CRC) is limited. Therefore, we constructed a lncRNA-related model based on data from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). Materials Methods: CRC transcriptome clinical were downloaded GSE20916 dataset TCGA database, respectively. R software was used for processing analysis. differential lncRNA expression within two datasets first screened, then intersections...
Abstract Replication factor C 5 (RFC5) is involved in a variety of biological functions cancer. However, the expression pattern RFC5 and underlying mechanisms colorectal cancer (CRC) remain elusive. Here, we show that significantly upregulated CRC tissues cells. Patients with increased levels have an unfavorable prognosis. can promote proliferation, migration, invasion cells inhibit apoptosis Additionally, upstream RFC5, constructed competing endogenous RNA network confirmed this was...
Colon cancer is one of the most common malignant tumors, with high rates incidence and death. The tumor mutational burden (TMB), which characterized by microsatellite instability, has been becoming a powerful predictor can show behavior response to immunotherapy.In this study, we analyzed 437 mutation data colon samples obtained from Cancer Genome Atlas (TCGA) divided patients into low- high-TMB groups according TMB value. Then identified differentially-expressed genes (DEGs), conducted...
Immune function is an important indicator for assessing postoperative recovery and long-term survival in patients with malignancy, laparoscopic surgery thought to have a less suppressive effect on the immune response than open surgery. This study aimed investigate this retrospective clinical study.In study, we enrolled 63 colorectal cancer Department of General Surgery First Affiliated Hospital Soochow University assessed changes their by measuring CD3+T, CD4+T, CD8+T lymphocytes, CD4+/CD8+...
Abstract Background We devised this study to quantify the effect of age on consumption cisatracurium under general anaesthesia, using a computer controlled closed loop infusion system. further investigated on, sufentanil and propofol consumption. Methods 74 patients physical status I II, requiring anaesthesia for elective abdominal surgery, were assigned three groups. Patients in group 1 aged from 20 45, 2 46 64, 3 above 65 years old. General Anesthesia was maintained with muscle paralysis...
<title>Abstract</title> Background Drug resistance is an important constraint on clinical outcomes in advanced cancers. LAMP2A a limiting protein molecular chaperone-mediated autophagy. This study was aimed to explore function cisplatin colorectal cancer (CRC) seek new ideas for CRC treatment. Methods In this study, expression analyzed by experimental techniques, such as qRT-PCR and western blot. Then, cells interfered cell transfection experiments. Subsequently, the of proliferation,...
To explore the role and mechanism of interleukin-8-mediated autophagy regulation gastric cancer (GC) cells in GC.After cell culture, SGC7901 line was separated into control group IL-8 (20 ng/mL) group, (40 (60 to verify effects PI3K/Akt signal path on modulation GC cells. Western blot detected markers, ATG12-ATG5 complexes, autophagy-associated pathways, apoptosis-associated factors Transwell utilized identify invasion capability.Compared with expression LC3II, Atg5, ATG7, Beclin1, Bax,...
Data sets of colorectal cancer (CRC) were obtained from The Cancer Genome Atlas (TCGA), three N6-methyladenosine (m6A) subtypes identified using 21 m6A-related long noncoding RNAs (lncRNAs) and differential m6A different CRC tumors determined in this study to evaluate the expression prognosis patients with CRC. Subsequently, eight key lncRNAs based on co-expression genes single-factor Cox least absolute shrinkage selection operator. Finally, an lncRNA risk score model tumor was established...
Objective To explore sensitive indicators for the initiation, development, and metastasis of gastric cancer to provide objective evidence early diagnosis, treatment, progression monitoring cancer. Methods A total 108 patients with were enrolled in this study.The expression interleukin receptor 1(CXCR1)in samples from adjacent tissues was detected by immunohistochemistry patient clinical data collected correlation analysis.Logistic regression analysis 5-year survival rate...
Mis-aspiration is a serious complication during peri-anesthesia. Bedside ultrasound can be used to assess the risk of aspiration by qualitative and quantitative estimation gastric contents. This review summarized recent literatures on reliability accuracy bedside for assessing aspiration. describes basic operation techniques procedures assessment patients with different special populations. has certain predictive value in peri-anesthesia, advantages reliability, repeatability. The study...
Objective To evaluate the value of bedside ultrasound-measured antral cross-sectional area (CSA) in diagnosing an empty stomach patients with chronic hepatitis B. Methods One hundred and fifty-nine B, aged 18-64 yr, body height>150 cm, weighing 45-110 kg, were enrolled this study.The antero-posterior diameter craniocaudal gastric antrum measured by ultrasound when supine position, CSA was calculated.Gastroscope negative pressure used to suction fluid from at end gastroscopy, volume...