A5007384587- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Immunotherapy and Biomarkers
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Mycobacterium research and diagnosis
- CAR-T cell therapy research
- Animal Genetics and Reproduction
- Nanomaterials for catalytic reactions
- Cancer Genomics and Diagnostics
- Genetic diversity and population structure
- Cancer Mechanisms and Therapy
- Viral-associated cancers and disorders
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Psoriasis: Treatment and Pathogenesis
- Ferroptosis and cancer prognosis
Nantong University
2025
Changshu No.1 People's Hospital
2013-2025
Northwest A&F University
2020-2022
Changshu No. 2 People's Hospital
2013-2022
Soochow University
2013-2014
First Affiliated Hospital of Soochow University
2013-2014
MicroRNAs (miRNAs) have been integrated into tumorigenic programs by regulating genes at post-transcriptional level. Long non-coding RNAs (lncRNAs) are novel targets for miRNAs. Here, we reported that miR-203 down-regulation was closely linked to advanced clinical features and poor overall survival (OS) of patients with hepatocellular carcinoma. We also confirmed oncogene ADAM9 (a disintegrin metalloproteinase 9)/oncogenic long RNA HULC (highly up-regulated in liver cancer) were inversely...
<title>Abstract</title> MiR-195-5p has been confirmed to be intimately linked many cancers development, whereas its role in gastric cancer (GC) remains controversial. The objective of this study was explore the potential function and mechanism miR-195-5p GC. First, level GC analyzed based on qRT-PCR TCGA STAD. Then, cells detected via CCK-8, clone formation assay, flow cytometry, transwell, wound healing assay. Subsequently, we explored possible using KEGG analysis, database Western blot,...
We aimed to study the role of LINC00997 in metastasis colorectal cancer (CRC). and miR-512-3p expression primary (NCRC) tissues metastatic (MCRC) were detected using RT-qPCR. The Cancer Genome Atlas database was used evaluate levels NCRC MCRC tissues, correlations with distant (M), regional lymph node (N), age tumor stage analyzed. Subsequently, RT-qPCR performed determine metastasis-related genes analyze correlation or level protein genes. In vitro, several CRC cell lines examined. After...
Dysregulation of SUMO-specific protease 1 (SENP1) expression has been reported in several kinds cancer, including human colorectal and prostate cancers, proposing SENP1 as an oncogene with a critical role cancer progression. miR-133a-3p tumor suppressor malignant neoplasias. However, the precise molecular mechanisms underlying its remain largely unknown. The aim this work was to investigate relationship between cells. We found that downregulated tissues. In silico analyses indicated is one...
miR-101 is an outstanding tumor suppressor in various cancers, while its role pancreatic cancer (PC) still unknown. The aim of this study was to investigate the epithelial-to-mesenchymal transition (EMT) and clinical relevance PC. Our data showed that expression significantly decreased human PC tissues, compared non-tumor counterparts (p<0.05), which reversely correlated characteristics, including lymph node metastasis, more venous infiltration, higher CA19-9 TNM stage (p<0.05). Low also...
Background: Knowledge about the prognostic role of long noncoding RNA (lncRNA) in colorectal cancer (CRC) is limited. Therefore, we constructed a lncRNA-related model based on data from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). Materials Methods: CRC transcriptome clinical were downloaded GSE20916 dataset TCGA database, respectively. R software was used for processing analysis. differential lncRNA expression within two datasets first screened, then intersections...
Drug resistance is an important constraint on clinical outcomes in advanced cancers. LAMP2A a limiting protein molecular chaperone-mediated autophagy. This study was aimed to explore function cisplatin (cis-diamminedichloroplatinum, DDP) colorectal cancer (CRC) seek new ideas for CRC treatment.
Colon cancer is one of the most common malignant tumors, with high rates incidence and death. The tumor mutational burden (TMB), which characterized by microsatellite instability, has been becoming a powerful predictor can show behavior response to immunotherapy.In this study, we analyzed 437 mutation data colon samples obtained from Cancer Genome Atlas (TCGA) divided patients into low- high-TMB groups according TMB value. Then identified differentially-expressed genes (DEGs), conducted...
Maternal origins based on the bovine mitochondrial D-loop region are proven to have two main origins: Bos taurus and indicus. To examine association between maternal of reproductive traits, complete sequences from 501 Chinese Holstein cows 94 individuals other breeds were analyzed. Based results obtained haplotype analysis, 260 SNPs (single nucleotide polymorphism), 32 indels (insertion/deletion), 219 haplotypes identified. Moreover, diversity (π) (Hd) 0.024 ± 0.001 0.9794 0.003,...
The ovary can generate oocytes and secrete female hormones thus is of great significance to animal fertility. In turn, the functioning this organ has an effect on profit margins livestock breeding industry. As development-regulating gene target miR-202, SEPT7 might play important role in ovarian growth. Therefore, we hypothesized that related traits owing regulation gonad-specific miR-202. To further investigate connection between bovine development, analyzed data from 408 samples. After...
<title>Abstract</title> Background Drug resistance is an important constraint on clinical outcomes in advanced cancers. LAMP2A a limiting protein molecular chaperone-mediated autophagy. This study was aimed to explore function cisplatin colorectal cancer (CRC) seek new ideas for CRC treatment. Methods In this study, expression analyzed by experimental techniques, such as qRT-PCR and western blot. Then, cells interfered cell transfection experiments. Subsequently, the of proliferation,...
To explore the role and mechanism of interleukin-8-mediated autophagy regulation gastric cancer (GC) cells in GC.After cell culture, SGC7901 line was separated into control group IL-8 (20 ng/mL) group, (40 (60 to verify effects PI3K/Akt signal path on modulation GC cells. Western blot detected markers, ATG12-ATG5 complexes, autophagy-associated pathways, apoptosis-associated factors Transwell utilized identify invasion capability.Compared with expression LC3II, Atg5, ATG7, Beclin1, Bax,...
Data sets of colorectal cancer (CRC) were obtained from The Cancer Genome Atlas (TCGA), three N6-methyladenosine (m6A) subtypes identified using 21 m6A-related long noncoding RNAs (lncRNAs) and differential m6A different CRC tumors determined in this study to evaluate the expression prognosis patients with CRC. Subsequently, eight key lncRNAs based on co-expression genes single-factor Cox least absolute shrinkage selection operator. Finally, an lncRNA risk score model tumor was established...
10629 Background: Expression of key enzymes the thymidylate synthase pathway may affect efficacy 5-FU and pro-drug capecitabine (C). The gene copy number (TS), thymidine phosphorylase (TP), dihydrofolate reductase (DHFR) (high vs low defined by median for each) was assessed correlated with time-to progression (TTP) progression-free survival (PFS). Methods: Adult female patients pathologically confirmed breast cancer locally advanced or metastatic disease were treated C 1000 mg/m2 BID days...